Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер unknown, С. 101147 - 101147
Опубликована: Ноя. 1, 2024
Язык: Английский
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(4), С. 2884 - 2925
Опубликована: Март 26, 2024
At present, the occurrence of a large number infectious and non-communicable diseases poses serious threat to human health as well drug development for treatment these diseases. One most significant challenges is finding new candidates that are therapeutically effective have few or no side effects. In this respect, active compounds in medicinal plants, especially flavonoids, potentially useful with wide range pharmacological activities. They naturally present nature valuable many Flavonoids divided into fourteen categories mainly derived from plant extraction, chemical synthesis structural modification, biosynthesis. The modification flavonoids an important way discover drugs, but biosynthesis currently considered promising research direction potential revolutionize production pipeline flavonoids. However, relevant problems such metabolic pathway analyses cell protocols need be addressed on urgent basis. review, techniques assessing biological activities mechanisms their elucidated modes interaction other drugs described. Moreover, novel delivery systems, nanoparticles, bioparticles, colloidals, etc., gradually becoming means addressing issues poor hydrophilicity, lipophilicity, stability, low bioavailability review summarizes latest progress existing therapeutic efficacy, how can solved
Язык: Английский
Процитировано
20
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 7, 2025
Radix Codonopsis (Dangshen), derived from the dried root of plants in Campanulaceae family, is a widely used Chinese herbal medicine. It renowned for its pharmacological effects, including tonifying middle qi, invigorating spleen, benefiting lungs, enhancing immunity, and nourishing blood. extract frequently incorporated into health products such as tablets capsules, making it accessible daily maintenance. Additionally, commonly dietary applications like soups, teas, porridges to nourish enrich blood, promote overall vitality. In recent years, increasing attention has been given anti-cancer potential Codonopsis. Studies have identified key active components luteolin, stigmasterol, polyacetylenes, lobetyolin, glycitein, which exhibit anti-tumor properties through mechanisms inhibiting cancer cell growth proliferation, suppressing epithelial-mesenchymal transition (EMT), inducing apoptosis. This review highlights research progress on Codonopsis, constituents, mechanisms, role convergence medicine food modern life. By doing so, aims provide valuable insights references future scientific studies clinical
Язык: Английский
Процитировано
1
Phytomedicine, Год журнала: 2023, Номер 123, С. 155220 - 155220
Опубликована: Ноя. 18, 2023
Язык: Английский
Процитировано
19
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Май 27, 2024
Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed and second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such delayed diagnosis, multidrug resistance, limited therapeutic effectiveness persist, emphasizing need for innovative approaches. This review explores potential natural products, nutraceuticals, phytochemicals targeting ferroptosis-related regulators novel strategy CRC. Ferroptosis, form regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance CRC progression therapy resistance. Natural known their diverse bioactive effects favorable safety profiles, emerge promising candidates to induce ferroptosis cells. Exploring amino acid, iron, metabolism regulators, oxidative stress reveals avenues inducing comprehensive provides insights into multifaceted products on proteins integral regulation, including GPX4, SLC7A11, ACSL4, NCOA4, HO-1. By elucidating intricate mechanisms through which modulate these proteins, this lays foundation
Язык: Английский
Процитировано
7
Phytotherapy Research, Год журнала: 2024, Номер 38(4), С. 2041 - 2076
Опубликована: Фев. 23, 2024
Abstract In recent years, heightened interest surrounds the exploration of natural phenols as potential agents for cancer therapy, specifically by inducing ferroptosis, a unique form regulated cell death characterized iron‐dependent lipid peroxidation. This review delves into roles key phenols, flavonoids, phenolic acids, curcumin, and stilbenes, in modulating ferroptosis their underlying mechanisms. Emphasizing significance amino acid, lipid, iron metabolism, study elucidates diverse pathways through which these regulate ferroptosis. Notably, well‐known polyphenol, exhibits multifaceted interactions with cellular components involved regulation, providing distinctive therapeutic avenue. Stilbenes, another class, demonstrate promising influencing metabolism processes, contributing to ferroptotic death. Understanding intricate interplay between not only illuminates complex regulatory networks but also unveils avenues novel therapies. Exploring compounds inducers presents strategy targeted treatment, capitalizing on delicate balance article synthesizes current knowledge, aiming stimulate further research context ferroptosis‐mediated therapy.
Язык: Английский
Процитировано
6
Antioxidants, Год журнала: 2024, Номер 13(3), С. 334 - 334
Опубликована: Март 10, 2024
Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.
Язык: Английский
Процитировано
5
Frontiers in Genetics, Год журнала: 2025, Номер 15
Опубликована: Янв. 29, 2025
Objectives This study employs bibliometric analysis to track evolution and identify trends of key topics in ferroptosis within the context lung cancer. By identifying emerging research areas, our aim is provide valuable insights directions for researchers this field. Methods Relevant papers reviews on cancer were retrieved from Web Science Core Collection database 5 February 2024. Bibliometric was conducted using CiteSpace 6.2.R3, VOSviewer 1.6.20, R 4.3.0, Microsoft Excel 2019. Results From 2015 2020, publications related sparse but showed a steady increase. Post-2020, there has been significant surge, with 6.4-fold increase observed by 2023. Overall, authors 4,033 institutions across 42 countries/regions contributed 606 published 262 academic journals. China emerged as leading contributor, while United States maintained dominance. Lifang Ma most prolific author, DIXON SJ, YANG WS, STOCKWELL BR being frequently co-cited. Effective communication collaboration among scholars are lacking. Key journals include Frontiers Pharmacology publication output, Nature Cell citation frequency. Research focuses molecular mechanisms ferroptosis, including endoplasmic reticulum stress, tumor microenvironment, autophagy. Therapeutic targets like GPX4, SLC7A11, P53, FSP1, Nrf2, LSH, STYK1/NOK, ACSL4 prominent. Traditional Chinese medicine also shows clinical value research. Conclusion Ferroptosis, promising avenue applications cancer, continues undergo rapid development. The iron death will remain critical focus future.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2025, Номер 139, С. 156465 - 156465
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265
Опубликована: Фев. 25, 2025
Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Март 6, 2025
Luteolin, a natural flavonoid compound, has demonstrated anti-inflammatory, antioxidant, and broad anti-tumor properties. Recent studies suggest that its effects are linked to enhanced CTL function-including proliferation, survival, cytotoxicity-via inhibition of the YAP/Wnt signaling pathway in tumor cells. Consequently, luteolin potential as an adjuvant combination therapies with adoptive immunotherapy. This study first assessed luteolin's tumor-inhibitory vitro vivo using cytotoxicity assays, Transwell invasion tests, wound healing analyses post-treatment growth survival time. Additionally, we explored whether combined DC/tumor fusion vaccine could synergistically enhance overall antitumor efficacy by boosting activation, cytokines secretion, effector T Our findings indicate luteolin, standalone agent, can inhibit proliferation colon lung cancer cells both certain extent. When activated CTLs, it upregulated expression CD25 CD69 resulted higher levels IL-2, TNF-α, IFN-γ secretion vitro. In vivo, this significantly curtailed subcutaneous extended mean time tumor-bearing mice (HCT116, A549), outperforming monotherapy. Furthermore, therapy may be attributable apoptosis cells, reduced decreased YAP expression. The vaccine-activated CTLs presents novel approach for treatment. As adjuvant, downregulates enhancing cytotoxicity, thus improving recognition selective targeting. strategy is promising safe effective
Язык: Английский
Процитировано
0