Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 87 - 104
Опубликована: Окт. 4, 2024
Язык: Английский
Cancer Letters, Год журнала: 2024, Номер 587, С. 216701 - 216701
Опубликована: Фев. 16, 2024
A new class of noncoding RNAs, tsRNAs are not only abundant in humans but also have high tissue specificity. Recently, an increasing number studies explored the correlations between and tumors, showing that can affect biological behaviors tumor cells, such as proliferation, apoptosis metastasis, by modulating protein translation, RNA transcription or posttranscriptional regulation. In addition, widely distributed stably expressed, which endows them with broad application prospects diagnosing predicting prognosis they expected to become biomarkers. However, notably, current research on still faces problems need be solved. this review, we describe characteristics well their unique features functions tumors. Moreover, discuss potential opportunities challenges clinical applications tsRNAs.
Язык: Английский
Процитировано
21
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 3, 2024
Abstract The clinical application of conventional medications for hepatocellular carcinoma treatment has been severely restricted by their adverse effects and unsatisfactory therapeutic effectiveness. Inspired the concept ‘medicine food homology’, we extracted purified natural exosome-like lipid nanoparticles (LNPs) from black mulberry ( Morus nigra L.) leaves. obtained MLNPs possessed a desirable hydrodynamic particle size (162.1 nm), uniform distribution (polydispersity index = 0.025), negative surface charge (-26.6 mv). These LNPs were rich in glycolipids, functional proteins, active small molecules (e.g., rutin quercetin 3- O -glucoside). In vitro experiments revealed that preferentially internalized liver tumor cell lines via galactose receptor-mediated endocytosis, increased intracellular oxidative stress, triggered mitochondrial damage, resulting suppressing viability, migration, invasion these cells. Importantly, vivo investigations suggested oral entered into circulatory system mainly through jejunum colon, they exhibited negligible superior anti-liver outcomes direct killing intestinal microbiota modulation. findings collectively demonstrate potential as natural, safe, robust nanomedicine carcinoma. Graphic abstract
Язык: Английский
Процитировано
20
ACS Omega, Год журнала: 2023, Номер 8(46), С. 43374 - 43387
Опубликована: Ноя. 9, 2023
Exosomes are nanoscale vesicles secreted by living cells that have similar membrane composition to parental and carry a variety of proteins, lipids, nucleic acids. Therefore, exosomes certain biological activities play an important role in intercellular communication. On the basis its potential as carrier for drug delivery systems, been engineered compensate shortage natural through various engineering strategies improving efficiency, enhancing targeting tissues organs, extending circulating half-life exosomes. This review focuses on loading drugs different strategies, discussions exosome surface modification summarizes advantages disadvantages strategies. In addition, this provides overview recent applications number refractory relapsable diseases. has provide reference further research development
Язык: Английский
Процитировано
34
ACS Applied Nano Materials, Год журнала: 2023, Номер 6(24), С. 22594 - 22610
Опубликована: Дек. 4, 2023
Nanomedicines, emerging as an innovative category of cancer therapeutics, have garnered increasing attention from both researchers and the broader public. However, despite this surge in interest, a focused comprehensive discussion highlighting their distinct advantages over small molecule drugs remains conspicuously absent. This knowledge gap not only piques curiosity general audience but also leaves engaged these investigations with partial insights, rather than understanding. deficiency represents critical juncture that demands earnest consideration. In light context, present study endeavors to consolidate elucidate unique merits nanomedicines, particularly contrast traditional drugs, within realm treatment. We meticulously summarized 14 nanomedicine, alongside recent advanced applications, special focus on past three years. Our objective is 2-fold: first, provide clear understanding facilitates precise design second, offer nonspecialists accessible platform for grasping concepts establishing strong foundation widespread awareness. essence, our aims bridge knowledge, shedding unparalleled potential nanomedicines therapy, we believe findings hold great promise advancing scientific research public field.
Язык: Английский
Процитировано
28
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(16)
Опубликована: Март 2, 2024
Hybrid nanomaterials have found use in many biomedical applications. This article provides a comprehensive review of the principles, techniques, and recent advancements design fabrication hybrid for biomedicine. We begin with an introduction to general concept material hybridization, followed by discussion how this approach leads materials additional functionality enhanced performance. then highlight forms nanostructures, nanocomposites, metal-organic frameworks, biohybrids, including their methods. also showcase advance engineering context nanomedicine, regenerative medicine, diagnostics, theranostics, biomanufacturing. Finally, we offer perspectives on challenges opportunities.
Язык: Английский
Процитировано
13
Angewandte Chemie, Год журнала: 2024, Номер 136(16)
Опубликована: Март 2, 2024
Abstract Hybrid nanomaterials have found use in many biomedical applications. This article provides a comprehensive review of the principles, techniques, and recent advancements design fabrication hybrid for biomedicine. We begin with an introduction to general concept material hybridization, followed by discussion how this approach leads materials additional functionality enhanced performance. then highlight forms nanostructures, nanocomposites, metal–organic frameworks, biohybrids, including their methods. also showcase advance engineering context nanomedicine, regenerative medicine, diagnostics, theranostics, biomanufacturing. Finally, we offer perspectives on challenges opportunities.
Язык: Английский
Процитировано
9
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 21, 2024
Abstract Tumors desmoplastic microenvironments are characterized by abundant stromal cells and extracellular matrix (ECM) deposition. Cancer-associated fibroblasts (CAFs), as the most of all cells, play significant role in mediating microenvironments, which not only remodel ECM to establish unique pathological barriers hinder drug delivery tumors, but also talk with immune cancer promote immunosuppression stem cells-mediated resistance. Thus, CAFs mediated will be emerging promising strategy treat tumors. However, due complexity heterogeneity such an effective deliver system should fully considered when designing targeting microenvironments. Engineered exosomes own powerful intercellular communication, cargoes delivery, penetration targeted property desired sites, endow them theranostic potential Here, we illustrate significance tumors engineered next generation personalized nano-drugs development. Graphical
Язык: Английский
Процитировано
6
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7470 - 7470
Опубликована: Июль 8, 2024
Colorectal cancer (CRC) is a significant public health challenge, with 5-fluorouracil (5-FU) resistance being major obstacle to effective treatment. Despite advancements, 5-FU remains formidable due complex mechanisms such as alterations in drug transport, evasion of apoptosis, dysregulation cell cycle dynamics, tumor microenvironment (TME) interactions, and extracellular vesicle (EV)-mediated pathways. Traditional chemotherapy often results high toxicity, highlighting the need for alternative approaches better efficacy safety. Phytochemicals (PCs) EVs offer promising CRC therapeutic strategies. PCs, derived from natural sources, exhibit lower toxicity can target multiple pathways involved progression resistance. facilitate targeted delivery, modulate immune response, interact TME sensitize cells However, potential PCs engineered overcoming reshaping immunosuppressive underexplored. Addressing this gap crucial identifying innovative therapies enhanced reduced toxicities. This review explores multifaceted evaluates synergistic effects combining improve treatment while minimizing adverse effects. Additionally, it investigates by serving delivery vehicles modulating TME. By synthesizing current knowledge addressing research gaps, enhances academic understanding CRC, interdisciplinary involving revolutionizing therapy. Further clinical validation are essential translating these findings into improved patient outcomes.
Язык: Английский
Процитировано
6
Nanoscale Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Despite recent advancements in cancer therapies, challenges such as severe toxic effects, non-selective targeting, resistance to chemotherapy and radiotherapy, recurrence of metastatic tumors persist. Consequently, there has been considerable effort explore innovative anticancer compounds, particularly immunotherapy, which offer the potential for enhanced biosafety efficacy prevention treatment. One avenue exploration involves miRNA-34 (miR-34) family, known its ability inhibit tumorigenesis across various cancers. Dysregulation miR-34 observed several human cancers, it is recognized a tumor suppressor microRNA due synergistic interaction with well-established p53. However, have arisen therapeutic application miR-34a. These include susceptibility degradation by RNase serum, limiting penetrate capillary endothelium reach target cells, well reports immunoreactive adverse reactions. Furthermore, unexpected side effects may occur, accumulation miRNAs healthy tissues interactions serum proteins on nano-vector surfaces, nanoparticle breakdown bloodstream shearing stress, unsuccessful extravasation nanocarriers cells owing interstitial fluid pressure. these challenges, miR-34a remains promising candidate therapy, other members family also shown inhibiting cell proliferation. While
Язык: Английский
Процитировано
6
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Май 27, 2024
Abstract Cancer cachexia (CC) is a debilitating syndrome that affects 50–80% of cancer patients, varying in incidence by type and significantly diminishing their quality life. This multifactorial characterized muscle fat loss, systemic inflammation, metabolic imbalance. Extracellular vesicles (EVs), including exosomes microvesicles, play crucial role the progression CC. These vesicles, produced cells others within tumor environment, facilitate intercellular communication transferring proteins, lipids, nucleic acids. A comprehensive review literature from databases such as PubMed, Scopus, Web Science reveals insights into formation, release, uptake EVs CC, underscoring potential diagnostic prognostic biomarkers. The also explores therapeutic strategies targeting EVs, which include modifying release content, utilizing them for drug delivery, genetically altering contents, inhibiting key pathways. Understanding CC opens new avenues approaches, potentially mitigating syndrome’s impact on patient survival
Язык: Английский
Процитировано
5