Chitosan-Based Biomaterials for Tissue Regeneration

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 807 - 807

Опубликована: Март 1, 2023

Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It numerous qualities make it attractive biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, many others. Importantly, chitosan can be fabricated into variety of structures including nanoparticles, scaffolds, hydrogels, membranes, which tailored to deliver desirable outcome. Composite chitosan-based biomaterials have been demonstrated stimulate in vivo the repair various tissues organs, but not limited to, bone, cartilage, dental, skin, nerve, cardiac, other tissues. Specifically, de novo formation, resident stem cell differentiation, extracellular matrix reconstruction were observed multiple preclinical models different injuries upon treatment with formulations. Moreover, proven efficient carriers medications, genes, bioactive compounds since they maintain sustained release these therapeutics. In this review, we discuss most recently published organ well delivery

Язык: Английский

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Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Molecules, Год журнала: 2023, Номер 28(3), С. 1473 - 1473

Опубликована: Фев. 3, 2023

The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hydrogels have frequently been used for hemostasis due their unique biocompatibility, tunable mechanical properties, injectability, and ease handling. Moreover, chitosan (CS) absorbs red blood cells activates platelets promote hemostasis. Benefiting from these desired the application CS attracting ever-increasing research attention. This paper reviews recent progress CS-based advantageous characteristics compared traditional materials. effects mechanism, deacetylation degree, relative molecular mass, chemical modification on performance are summarized. Meanwhile, some typical applications introduced provide references preparation efficient hydrogels. Finally, future perspectives presented.

Язык: Английский

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Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Carbohydrate Polymers, Год журнала: 2023, Номер 323, С. 121408 - 121408

Опубликована: Сен. 17, 2023

Язык: Английский

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Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review

Gels, Год журнала: 2023, Номер 9(2), С. 138 - 138

Опубликована: Фев. 6, 2023

Wound healing is a long-term and complex biological process that involves multiple hemostasis, inflammation, proliferation, remodeling stages. In order to realize comprehensive systematic wound management, appropriate treatment bio-adhesives are urgently needed. Hydrogel have excellent properties show unique remarkable advantages in the field of management. This review begins with detailed description design criteria functionalities ideal hydrogel for healing. Then, recent advances polysaccharide-based multifunctional bio-adhesives, which involve chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, other polysaccharides, comprehensively discussed. Finally, current challenges future research directions proposed stimulate further exploration by researchers.

Язык: Английский

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Chitosan-based self-healing hydrogel dressing for wound healing

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 332, С. 103267 - 103267

Опубликована: Авг. 3, 2024

Язык: Английский

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Rapidly degrading and mussel-inspired multifunctional carboxymethyl chitosan/montmorillonite hydrogel for wound hemostasis

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124960 - 124960

Опубликована: Май 23, 2023

Язык: Английский

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Angiogenesis, hemocompatibility and bactericidal effect of bioactive natural polymer‐based bilayer adhesive skin substitute for infected burned wound healing

Bioactive Materials, Год журнала: 2023, Номер 29, С. 177 - 195

Опубликована: Июль 15, 2023

Thermal wounds are complex and lethal with irregular shapes, risk of infection, slow healing, large surface area. The mortality rate in patients infected burns is twice that non-infected burns. Developing multifunctional skin substitutes to augment the healing vital. Herein, we 3D printed a hydrogel scaffold comprising carboxymethyl chitosan (CMCs) oxidized alginate grafted catechol (O-AlgCat) on hydrophobic electrospun layer, forming bilayer substitute (BSS). functional layer (FL) was fabricated by physiochemical crosslinking ensure favorable biodegradability. gallium-containing or backing (BL) could mimic epidermis skin, avoiding fluid penetration offering antibacterial activity. FL contains catechol, gallium, biologically active platelet rich fibrin (PRF) adhere both tissue BL, show activity, encourage angiogenesis, cell growth, migration. bioactive BSS exhibited noticeable adhesive properties (P ≤ 0.05), significant activity faster clot formation, potential promote proliferation 0.05) migration L929 cells. Furthermore, angiogenesis significantly higher when evaluated vivo ovo. BSS-covered healed due low inflammation high collagen density. Based obtained results, be an effective treatment for burn wounds.

Язык: Английский

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Injectable multifunctional carboxymethyl chitosan/hyaluronic acid hydrogel for drug delivery systems

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 249, С. 125801 - 125801

Опубликована: Июль 11, 2023

Язык: Английский

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Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review

Carbohydrate Polymers, Год журнала: 2024, Номер 333, С. 121952 - 121952

Опубликована: Фев. 19, 2024

Язык: Английский

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Self-healing hydrogels as injectable implants: Advances in translational wound healing

Coordination Chemistry Reviews, Год журнала: 2024, Номер 509, С. 215790 - 215790

Опубликована: Март 20, 2024

Язык: Английский

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