Journal of Molecular Liquids, Год журнала: 2024, Номер 397, С. 124115 - 124115
Опубликована: Янв. 26, 2024
Язык: Английский
Fuel, Год журнала: 2024, Номер 365, С. 130751 - 130751
Опубликована: Фев. 19, 2024
Язык: Английский
Процитировано
30
International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100265 - 100265
Опубликована: Июнь 26, 2024
Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.
Язык: Английский
Процитировано
20
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 293, С. 139426 - 139426
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
Polymers, Год журнала: 2025, Номер 17(4), С. 435 - 435
Опубликована: Фев. 7, 2025
Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential
Язык: Английский
Процитировано
4
Nanomaterials, Год журнала: 2025, Номер 15(5), С. 356 - 356
Опубликована: Фев. 25, 2025
Cellulose nanofibers (CNFs), cellulose nanomaterials (CNMs), and cellulose-based composites represent a convergence of material science, sustainability, advanced engineering, paving the way for innovative eco-friendly materials. This paper presents comprehensive review these materials, encompassing their extraction, preparation methods, properties, applications, future directions. The manufacturing CNFs CNMs leverages diverse techniques-chemical, mechanical, enzymatic-with each offering distinct advantages in tailoring characteristics to meet specific needs. Strategies functionalization surface modification are detailed, highlighting role enhancing properties while addressing challenges scaling production industrial levels. structural, thermal, optical, electrical, biocompatibility CNFs, CNMs, explored, underscoring versatility applications across various industries. Cellulose-based composites, particular, demonstrate exceptional tunable uses, although achieving uniform dispersion remains key technical hurdle. These materials have packaging, automotive, aerospace, biomedical devices, energy storage, environmental remediation. Emerging research trends emphasize integration with technologies, promoting sustainable practices life cycle considerations advancing commercialization potential. rapidly evolving field holds immense promise global by creating high-performance, is crucial understanding nanofibers, nanomaterials, providing valuable insights that will drive development sustainable, high-performance wide range ultimately challenges.
Язык: Английский
Процитировано
3
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Since the invention and commercialization of poly(
Язык: Английский
Процитировано
2
ACS Applied Bio Materials, Год журнала: 2025, Номер 8(3), С. 1749 - 1784
Опубликована: Фев. 18, 2025
Lenvatinib (LEN), a tyrosine kinase inhibitor, has emerged as promising therapeutic agent for various solid tumors. Nevertheless, number of constraints, including diminished bioavailability, incapacity to elicit localized inflammation, and inability selectively accumulate at the tumor site, may impede comprehensive exploitation its versatile inhibitory capabilities. In order achieve targeted delivery LEN while also reducing high dose used in conventional therapeutics, nanoformulation approaches can be adopted. The integration into nanoformulations, such nanoparticles, nanocrystals, density lipoproteins (HDLs), liposomes, micelles, is discussed, highlighting advantages these innovative comparative manner; however, given that current methods synthesis employ toxic organic solvents chemicals, there an imperative need exploring alternative, environmentally friendly approaches. multifaceted effects nanocarriers have rendered them profoundly applicable within biomedical domain, serving instrumental entities capacities vehicles drug genetic material, diagnostic agents, facilitators photothermal therapy, radiotherapy. However, scalability nanotechnological methodologies must rigorously investigated addressed refine mechanisms. This endeavor offers prospects revolutionizing strategies cancer thereby laying foundation future research scale-up techniques pursuit more effective less therapies cancer.
Язык: Английский
Процитировано
2
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 92, С. 105342 - 105342
Опубликована: Янв. 4, 2024
Язык: Английский
Процитировано
12
Polymers, Год журнала: 2024, Номер 16(6), С. 852 - 852
Опубликована: Март 20, 2024
This study focuses on the mechanical properties of electrospun nanofibrous mats, highlighting importance characteristics single nanofibers in determining overall behavior mats. Recognizing significant impacts diameter and structural nanofibers, this research introduces a novel methodology for deriving effects aggregate performance oriented nanofiber For purpose, finite element method (FEM) model is developed to simulate elastoplastic response incorporating influence parameters properties. The validation FEM against experimental data from polyacrylonitrile (PAN) with different orientations demonstrates its effectiveness capturing elastic-plastic tensile behaviors material confirms accuracy terms reflecting complex interactions within Through detailed analysis how diameter, orientation fibers, length-to-width ratio, porosity affect provides valuable insights engineering materials meet specific requirements. These findings improve our understanding mat structures, allowing better diverse applications as well critical identifying their associated design.
Язык: Английский
Процитировано
12
Future Postharvest and Food, Год журнала: 2024, Номер 1(1), С. 5 - 33
Опубликована: Янв. 9, 2024
Abstract In nature, cellulose is present in fibrillar structures with alternative crystalline and amorphous fragments. The application of various chemical treatments (acid hydrolysis, enzymolysis, oxidation) could lead to the extraction purification compartments form nanocrystals. On other hand, applying harsh mechanical (milling, ultrasonication, high‐pressure processing, grinding, microfluidization, etc.) result degradation macrostructures into nano‐fibrillated segments without depletion fractions. These are called nanofibers. Bacterial nanocelluloses (BNCs) another nanostructure that generated through bottom–up technique. BNCs purest forms nanostructures (CNSs). Hitherto, spectroscopy microscopy characterization techniques have been developed for in‐depth investigation CNSs. valuable information obtained via such instrumental has opened windows on new horizons CNSs novel realms. Nowadays, found a seat biomedical, packaging, emulsification, water filtration, textile applications. this review, after describing their fabrication methods, most recent utilized these plus current different realms comprehensively overviewed.
Язык: Английский
Процитировано
10