Fabrication and Facile Surface Derivatization of Poly(ε‐caprolactone)‐Based Wound Dressing Materials Imparting Anti‐Infective, Excessive Biofluid Drainage, and Easy‐to‐Peel Characteristics DOI

Hemanjali Mude,

Pranathi Tata,

Jamma Trinath

et al.

Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 6(5)

Published: March 2, 2023

Abstract The rapid emergence of antimicrobial resistance warrants an antibiotic‐free approach to counter the bacterial threat in all possible applications environmental and biomedical domains. In context smart wound dressing, besides imparting anti‐infective characteristics a nonconventional fashion, it is also essential imbibe multifunctional attributes like excessive biofluid drainage, easy‐to‐peel, optimal gas permeation, etc., for which appropriate material design prime requisite. this work, poly(ε‐caprolactone) (PCL)− FDA approved biocompatible polyester− chosen properties by surface derivatization with molecularly‐dispersed ionic silver over quaternary ammonium moieties through facile room temperate organic solvent‐free approach. To render other mentioned above, two different systems comprising PCL varying porosity, namely, electrospun fibers polyester‐coated cotton gauze, are developed. dressing materials thoroughly characterized assessed their structural, chemical, morphological, wettability, antibacterial, peel strength as function steps. bactericidal performance ammonium‐functionalized surfaces has enhanced manifold (≈7–10) after derivatizing silver. vivo efficacy study employing reveals derivatized most promising candidate, followed gauze‐coated 5% PCL.

Language: Английский

Advancements in lignocellulosic biomass: A critical appraisal of fourth-generation biofuels and value-added bioproduct DOI
Veeramuthu Ashokkumar,

V.P. Chandramughi,

Gopalakrishnan Kumar

et al.

Fuel, Journal Year: 2024, Volume and Issue: 365, P. 130751 - 130751

Published: Feb. 19, 2024

Language: Английский

Citations

29
Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters DOI Creative Commons

Vahid Tayebi-Khorrami,

Pouria Rahmanian‐Devin, Mohammad Reza Fadaei

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100265 - 100265

Published: June 26, 2024

Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.

Language: Английский

Citations

19
Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review DOI Open Access
Popat Mohite, Abhijeet Puri, Shubham Munde

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 435 - 435

Published: Feb. 7, 2025

Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based systems, particularly nanoparticles (NPs) nanofibers (NFs), emerged promising solutions for biomedicine delivery. NFs, with their ability to mimic the porous fibrous structures of biological tissues, garnered significant interest in drug-delivering applications. Biopolymers gelatin (Ge) chitosan (CH) gained much more attention due biocompatibility, biodegradability, versatility biomedical CH exhibits exceptional anti-bacterial activity, wound healing capabilities, whereas Ge provides good biocompatibility cell adhesion properties. Ge/CH-based NFs stimulate cellular connections facilitate tissue regeneration owing structural resemblance extracellular matrix. This review explores additive preparation, including electrospinning, force pinning, template synthesis, focusing on electrospinning factors influencing fiber structure. The properties CH, role release, formulation strategies, characterization techniques electrospun fibers are discussed. Furthermore, this addresses applications delivering active moieties management orthopedics regulatory considerations, along challenges related them. Thus, aims provide a comprehensive overview potential

Language: Английский

Citations

4
Recent progress in biopolymer-based electrospun nanofibers and their potential biomedical applications: A review DOI
Dinesh K. Patel,

So-Yeon Won,

Eunseo Jung

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 293, P. 139426 - 139426

Published: Jan. 1, 2025

Language: Английский

Citations

3
A Comprehensive Review on Cellulose Nanofibers, Nanomaterials, and Composites: Manufacturing, Properties, and Applications DOI Creative Commons

Subin Antony Jose,

Neil D. Cowan,

Matthew Davidson

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 356 - 356

Published: Feb. 25, 2025

Cellulose nanofibers (CNFs), cellulose nanomaterials (CNMs), and cellulose-based composites represent a convergence of material science, sustainability, advanced engineering, paving the way for innovative eco-friendly materials. This paper presents comprehensive review these materials, encompassing their extraction, preparation methods, properties, applications, future directions. The manufacturing CNFs CNMs leverages diverse techniques-chemical, mechanical, enzymatic-with each offering distinct advantages in tailoring characteristics to meet specific needs. Strategies functionalization surface modification are detailed, highlighting role enhancing properties while addressing challenges scaling production industrial levels. structural, thermal, optical, electrical, biocompatibility CNFs, CNMs, explored, underscoring versatility applications across various industries. Cellulose-based composites, particular, demonstrate exceptional tunable uses, although achieving uniform dispersion remains key technical hurdle. These materials have packaging, automotive, aerospace, biomedical devices, energy storage, environmental remediation. Emerging research trends emphasize integration with technologies, promoting sustainable practices life cycle considerations advancing commercialization potential. rapidly evolving field holds immense promise global by creating high-performance, is crucial understanding nanofibers, nanomaterials, providing valuable insights that will drive development sustainable, high-performance wide range ultimately challenges.

Language: Английский

Citations

3
Poly(p-Phenylene Benzobisoxazole) Nanofiber: A Promising Nanoscale Building Block Toward Extremely Harsh Conditions DOI
Baolong Yuan, Bin Yang, Ping Xu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Since the invention and commercialization of poly(

Language: Английский

Citations

2
Gum Arabic: A Commodity with Versatile Formulations and Applications DOI Creative Commons
Shaymaa Abdelghany Mohamed, Asmaa M. Elsherbini, Heba R. Alrefaey

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 290 - 290

Published: Feb. 13, 2025

Gum Arabic (GA), or acacia gum, refers to the dried exudate produced by certain Acacia trees. GA is composed mainly of a mixture polysaccharides and glycoproteins, with proportions that can slightly differ from one species another. It commonly utilized in food pharmaceutical industries as stabilizer an emulsifier owing its biocompatibility, hydrophilicity, antibacterial properties. In addition, be manipulated it possesses many functional groups used grafting, cross-linking, chemical modifications add new feature developed material. this review, we highlight recent GA-based formulations, including nanoparticles, hydrogels, nanofibers, membranes, scaffolds, their possible applications tissue regeneration, cancer therapy, wound healing, biosensing, bioimaging, packaging, antimicrobial antifouling membranes.

Language: Английский

Citations

2
A Finite Element Method for Determining the Mechanical Properties of Electrospun Nanofibrous Mats DOI Open Access
Jaymin Vrajlal Sanchaniya, Inga Ļašenko,

Valters Gobins

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(6), P. 852 - 852

Published: March 20, 2024

This study focuses on the mechanical properties of electrospun nanofibrous mats, highlighting importance characteristics single nanofibers in determining overall behavior mats. Recognizing significant impacts diameter and structural nanofibers, this research introduces a novel methodology for deriving effects aggregate performance oriented nanofiber For purpose, finite element method (FEM) model is developed to simulate elastoplastic response incorporating influence parameters properties. The validation FEM against experimental data from polyacrylonitrile (PAN) with different orientations demonstrates its effectiveness capturing elastic-plastic tensile behaviors material confirms accuracy terms reflecting complex interactions within Through detailed analysis how diameter, orientation fibers, length-to-width ratio, porosity affect provides valuable insights engineering materials meet specific requirements. These findings improve our understanding mat structures, allowing better diverse applications as well critical identifying their associated design.

Language: Английский

Citations

12
Electrospun nanofiber drug delivery systems and recent applications: An overview DOI
Semsi Muratoglu, Murat İnal, Yagmur Akdağ

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105342 - 105342

Published: Jan. 4, 2024

Language: Английский

Citations

11
Cellulose nanofibers, nanocrystals, and bacterial nanocellulose: Fabrication, characterization, and their most recent applications DOI Creative Commons
Hadis Rostamabadi, Yograj Bist, Yogesh Kumar

et al.

Future Postharvest and Food, Journal Year: 2024, Volume and Issue: 1(1), P. 5 - 33

Published: Jan. 9, 2024

Abstract In nature, cellulose is present in fibrillar structures with alternative crystalline and amorphous fragments. The application of various chemical treatments (acid hydrolysis, enzymolysis, oxidation) could lead to the extraction purification compartments form nanocrystals. On other hand, applying harsh mechanical (milling, ultrasonication, high‐pressure processing, grinding, microfluidization, etc.) result degradation macrostructures into nano‐fibrillated segments without depletion fractions. These are called nanofibers. Bacterial nanocelluloses (BNCs) another nanostructure that generated through bottom–up technique. BNCs purest forms nanostructures (CNSs). Hitherto, spectroscopy microscopy characterization techniques have been developed for in‐depth investigation CNSs. valuable information obtained via such instrumental has opened windows on new horizons CNSs novel realms. Nowadays, found a seat biomedical, packaging, emulsification, water filtration, textile applications. this review, after describing their fabrication methods, most recent utilized these plus current different realms comprehensively overviewed.

Language: Английский

Citations

9