Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(8), С. 3238 - 3251
Опубликована: Май 23, 2023
Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding biological systems. With advanced analytical techniques, metabolomics exhibits unprecedented significant value basic drug research, including disease mechanisms, identifying targets, and elucidating mode action drugs. More importantly, greatly accelerates development process by predicting pharmacokinetics, pharmacodynamics, response. In addition, facilitates exploration repurposing drug-drug interactions, as well personalized treatment strategies. Here, we briefly review recent advances technologies update our knowledge applications research development.
Язык: Английский
Процитировано
31Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering
Materials, Год журнала: 2023, Номер 16(8), С. 3197 - 3197
Опубликована: Апрель 18, 2023
In recent years, three-dimensional (3D) bioprinting has been widely utilized as a novel manufacturing technique by more and researchers to construct various tissue substitutes with complex architectures geometries. Different biomaterials, including natural synthetic materials, have manufactured into bioinks for regeneration using 3D bioprinting. Among the biomaterials derived from tissues or organs, decellularized extracellular matrix (dECM) internal structure variety of bioactive factors that provide mechanistic, biophysical, biochemical signals remodeling. developing dECM bioink construction substitutes. Compared other bioinks, ECM components in dECM-based can regulate cellular functions, modulate process, adjust Therefore, we conducted this review discuss current status perspectives on engineering. addition, techniques decellularization methods were also discussed study.
Язык: Английский
Процитировано
21Metabolomics and lipidomics strategies in modern drug discovery and development
Drug Discovery Today, Год журнала: 2023, Номер 28(10), С. 103751 - 103751
Опубликована: Авг. 26, 2023
Язык: Английский
Процитировано
18Understanding the physiological mechanisms and therapeutic targets of diseases: Lipidomics strategies
Life Sciences, Год журнала: 2025, Номер 363, С. 123411 - 123411
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0Lipidomics unravels lipid changes in osteoarthritis articular cartilage
Annals of the Rheumatic Diseases, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Osteoarthritis (OA) is linked to disrupted lipid metabolism. We aimed profile the composition of human articular cartilage, investigate OA-associated lipidome changes, and explore biological effects. Lipidomic profiling computational analyses were performed on chondrocytes (hACs) from non-OA (n = 13) OA 14) hips. Lipid changes confirmed in destabilisation medial meniscus (DMM) mouse model. The effect specific lipids was evaluated by vitro supplementation gene silencing. identified 573 species covering 11 classes hACs. hACs showed distinct profiles. Most ceramides dihydroceramides increased, while cholesteryl esters, diacylglycerols, triacylglycerols, sphingomyelins, hexosylceramides, lactosylceramides predominantly decreased chondrocytes. upregulated contained C18:1, C20:4, or C22:4 side chains. Many downregulated C18:2 odd-chain C17:0. cartilage DMM model paralleled hACs, including C17:0 reduction. Further analysis that deficiency enzyme 2-hydroxyacyl-CoA lyase 1 (HACL1), responsible for fatty acid synthesis, leads accumulation 2-hydroxy C18:0, precursor C17:0, which results a shift an anabolic catabolic state. Our study maps hAC highlights profiles associated with OA. Dysregulation certain lipids, especially acids, HACL1, pathological changes. This understanding opens potential avenues therapies at targeting imbalances slow down treat
Язык: Английский
Процитировано
0Causal Association Between Multidimensional Plasma Lipid Composition and Pediatric Asthma: A Mendelian Randomization Study
Pediatric Pulmonology, Год журнала: 2025, Номер 60(2)
Опубликована: Фев. 1, 2025
Asthma is the most common chronic disease among children and poses a major threat to their health. Observational studies have shown lipid disorders in with asthma. However, it was not possible determine whether there causal link between two. Therefore, aim of this study assess relationship serum liposomes asthma children. We used large-scale publicly available genome-wide association summary statistics elucidate associations plasma using two-sample Mendelian randomization (MR) approach. The IVW method as primary analysis method, tests such Cochran Q test, MR-Egger intercept, leave-one-out were utilized explore heterogeneity pleiotropy MR results. In addition, Steiger's test reverse performed directionality Our results identified six childhood Among them, negative Diacylglycerol (16:0_18:2) (OR = 0.952, 95%CI 0.913-0.992, p 0.018), Triacylglycerol (52:4) 0.949, 0.905-0.994, 0.028), Phosphatidylcholine (18:2_20:3) 0.915, 0.843-0.993, 0.034), sterol ester (27:1/22:6) 0.929, 95% CI 0.869-0.994, 0.031) There positive (16:0_22:5) 1.061, 1.006-1.120, 0.030), (27:1/20:4) 1.046, 1.021-1.072, 0.0003) pediatric A series sensitivity also demonstrate robustness This some will provide new perspectives on prevention treatment future.
Язык: Английский
Процитировано
0Exploring the Impact of Organic Solvent Quality and Unusual Adduct Formation during LC-MS-Based Lipidomic Profiling
Metabolites, Год журнала: 2023, Номер 13(9), С. 966 - 966
Опубликована: Авг. 22, 2023
Liquid chromatography-mass spectrometry (LC-MS) is the key technique for analyzing complex lipids in biological samples. Various LC-MS modes are used lipid separation, including different stationary phases, mobile-phase solvents, and modifiers. Quality control lipidomics analysis crucial to ensuring generated data's reliability, reproducibility, accuracy. While several quality measures commonly discussed, impact of organic solvent during often overlooked. Additionally, annotation remains prone biases, leading potential misidentifications incomplete characterization species. In this study, we investigate how LC-MS-grade isopropanol from vendors may influence mobile phase LC-MS-based untargeted lipidomic profiling Furthermore, report occurrence an unusual, yet highly abundant, ethylamine adduct [M+46.0651]
Язык: Английский
Процитировано
8OncoSexome: the landscape of sex-based differences in oncologic diseases
Nucleic Acids Research, Год журнала: 2024, Номер 53(D1), С. D1443 - D1459
Опубликована: Ноя. 13, 2024
The NIH policy on sex as biological variable (SABV) emphasized the importance of sex-based differences in precision oncology. Over 50% clinically actionable oncology genes are sex-biased, indicating drug efficacy. Research has identified non-reproductive cancers, highlighting need for comprehensive cancer data. We therefore developed OncoSexome, a multidimensional knowledge base describing (https://idrblab.org/OncoSexome/) across four key topics: antineoplastic drugs and responses (SDR), oncology-related biomarkers (SBM), risk factors (SRF) microbial landscape (SML). SDR covers 2051 anticancer drugs; SBM describes 12 551 sex-differential biomarkers; SRF illustrates 350 sex-dependent factors; SML demonstrates 1386 microbes with abundances associated development. OncoSexome is unique illuminating multifaceted influences cancer, providing both external endogenous contributors to development broadest oncological classes. Given increasing global research interest differences, expected impact future practices significantly.
Язык: Английский
Процитировано
2Impaired hepatic lipid metabolism and biomarkers in fatty liver disease
Biochimie, Год журнала: 2023, Номер 215, С. 69 - 74
Опубликована: Сен. 26, 2023
Язык: Английский
Процитировано
5Clinical advances in analytical profiling of signature lipids: implications for severe non-communicable and neurodegenerative diseases
Metabolomics, Год журнала: 2024, Номер 20(2)
Опубликована: Март 8, 2024
Язык: Английский
Процитировано
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