Stimulus‐Responsive Nano‐Prodrug Strategies for Cancer Therapy: A Focus on Camptothecin Delivery DOI
Bingyang Chu,

Hanzhi Deng,

Ting Niu

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 8(8)

Published: Dec. 12, 2023

Camptothecin (CPT) is a highly cytotoxic molecule with excellent antitumor activity against various cancers. However, its clinical application severely limited by poor water solubility, easy inactivation, and severe toxicity. Structural modifications nanoformulations represent two crucial avenues for camptothecin's development. the potential further structural limited, camptothecin nanoparticles fabricated via physical loading have drawbacks of low drug leakage. Prodrug-based CPT shown unique advantages, including increased loading, reduced burst release, improved bioavailability, minimal toxic side effects. Stimulus-responsive nano-prodrugs that respond to endogenous or exogenous stimuli introducing activatable linkers achieve spatiotemporally responsive release at tumor site. This review comprehensively summarizes latest research advances in stimulus-responsive nano-prodrugs, preparation strategies, mechanisms, their applications cancer therapy. Special focus placed on mechanisms characteristics treatment. Furthermore, prodrugs are discussed. Finally, challenges future directions be valuable readers engaged prodrug expected.

Language: Английский

Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy DOI
Shenwu Zhang, Jing Wang,

Zhiqiang Kong

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 282, P. 121433 - 121433

Published: Feb. 19, 2022

Language: Английский

Citations

185
Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review DOI Creative Commons
Bingqian Li,

Huili Shao,

Lei Gao

et al.

Drug Delivery, Journal Year: 2022, Volume and Issue: 29(1), P. 2130 - 2161

Published: July 10, 2022

Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by inability drug to be solely delivered tumor when treating cancer with chemotherapy. Natural products attracted more and attention due antitumor effect multiple ways, abundant resources less effects. Therefore, combination natural active ingredients chemotherapy may an effective strategy, which can inhibit growth multidrug resistance, reduce drugs. Nano-drug co-delivery system (NDCDS) play important role This review provides comprehensive summary research status application prospect nano-delivery strategies drugs, aiming provide basis development anti-tumor

Language: Английский

Citations

164
Advancement of cancer immunotherapy using nanoparticles-based nanomedicine DOI

Vemana Gowd,

Anas Ahmad,

Mohammad Tarique

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 624 - 644

Published: April 1, 2022

Language: Английский

Citations

83
Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy DOI
Ping Huang, Yao Yang, Wenyan Wang

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 299, P. 122157 - 122157

Published: May 9, 2023

Language: Английский

Citations

58
Nanotechnology-empowered strategies in treatment of skin cancer DOI

Jyoti Chandra,

Nazeer Hasan, Nazim Nasir

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 235, P. 116649 - 116649

Published: July 13, 2023

Language: Английский

Citations

42
Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy DOI Creative Commons
Shaomin Yan, Yu Gan, Huizhe Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.

Language: Английский

Citations

2
Nano-delivery systems for food bioactive compounds in cancer: prevention, therapy, and clinical applications DOI
Ítalo Rennan Sousa Vieira, Carlos Adam Conté-Júnior

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(2), P. 381 - 406

Published: Aug. 8, 2022

Bioactive compounds represent a broad class of dietary metabolites derived from fruits and vegetables, such as polyphenols, carotenoids glucosinolates with potential for cancer prevention. Curcumin, resveratrol, quercetin, β-carotene have been the most widely applied bioactive in chemoprevention. Lately, many approaches to encapsulating components nano-delivery systems improved biomolecules' stability targeted delivery. In this review, we critically analyze compounds, including polymeric nanoparticles (NPs), solid lipid (SLN), nanostructured carriers (NLC), liposomes, niosomes, nanoemulsions (NEs) use therapy. Efficacy studies nanoformulations using cell lines vivo models updated human clinical trials are also discussed. Nano-delivery were found improve therapeutic efficacy molecules against various types (e.g., breast, prostate, colorectal lung cancer) mainly due antiproliferation pro-apoptotic effects tumor cells. Furthermore, some promised combination therapy standard chemotherapeutic agents, increased efficiency fewer side effects. These opportunities identified developed ensure more excellent safety novel herbal medicines enabling insights designing

Language: Английский

Citations

46
Biomaterials That Induce Immunogenic Cell Death DOI
Di Li, Siqi Liu, Yang Ma

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: April 28, 2023

Abstract The immune system takes part in most physiological and pathological processes of the body, including occurrence development cancer. Immunotherapy provides a promising modality for inhibition even cure During immunotherapy, immunogenic cell death (ICD) tumor cells induced by chemotherapy, radiotherapy, phototherapy, bioactive materials, so forth, triggers series cellular responses causing release tumor‐associated antigens damage‐associated molecular patterns, which ultimately activate innate adaptive responses. Among them, ICD‐induced biomaterials attract increasing conditions as benefit biosafety multifunctional modifications. This Review summarizes research progress inducing ICD via triggering endoplasmic reticulum oxidative stress, mitochondrial dysfunction, membrane rupture discusses application prospects ICD‐inducing clinical practice cancer immunotherapy.

Language: Английский

Citations

40
Tumor Microenvironment Mediated Spermidine-Metal-Immunopeptide Nanocomplex for Boosting Ferroptotic Immunotherapy of Lymphoma DOI
Tianqi Nie, Hengyu Liu,

Zhengwen Fang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 10925 - 10937

Published: May 23, 2023

Immunotherapy as an alternative treatment strategy for B-cell lymphoma is undesirable because of tumor heterogeneity and immune surveillance. Spermidine (SPM), a regulator the microenvironment (TME), can facilitate release damage-associated molecular patterns (DAMPs) from cancer cells, promote recognition, thus alleviate surveillance in TME. Hence, this work, self-assembled spermidine-based metal-immunopeptide nanocomplexes (APP-Fe NCs; APP anti-programmed death ligand-1 peptide) with pH-responsive kinetics were prepared via flash nanocomplexation (FNC) technique based on noncovalent interaction between APP-SPM-dextran (DEX) sodium tripolyphosphate (TPP) coordination Fe3+ TPP. An vitro study suggested that APP-Fe NCs effectively induce strong oxidative stress mitochondrial dysfunction subsequently lead to ferroptosis cells by interfering homeostasis cells. Further investigation mice models demonstrated inhibited growth liver metastasis lymphomas. Mechanistically, triggering tissues, these spermidine-containing efficiently facilitated DAMPs ultimately reshaped TME enhance immunotherapy efficacy lymphoma. Combined its good histocompatibility facile preparation technique, regulation may hold potential cascade amplification combinative clinic.

Language: Английский

Citations

31
A Dual‐Targeting Liposome Enhances Triple‐Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation DOI
Kaipei Luo, Lu Yang, Chunmei Yan

et al.

Small, Journal Year: 2023, Volume and Issue: 19(40)

Published: June 1, 2023

Immunotherapy gains increasing focus in treating triple-negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive microenvironment (ITM). Herein, a LyP-1 chondroitin sulfate (CS) dual-modified liposome co-loaded with paclitaxel (PTX) cryptotanshinone (CTS), namely CS/LyP-1-PC Lip, engineered for TNBC chemoimmunotherapy via induction of immunogenic cell death (ICD) inhibition signal transducer activator transcript-3 (STAT3) activation. Lip enhances cellular uptake through p32 CD44 dual receptor-mediated endocytosis. Within the tumor, CS layer continuously detached by hyaluronidase release drugs. Subsequently, CTS sensitizes cytotoxicity PTX 4T1 cells. induces ICD cells facilitates infiltration cytotoxic T lymphocyte provoke immune response. Meanwhile, concomitant delivery inhibits STAT3 activation decrease regulatory cell, M2-type tumor-associated macrophage, myeloid-derived suppressor thus reversing ITM. Markedly, dual-targeting shows superior anti-tumor subcutaneous mice significant lung metastasis suppression model. Overall, this work offers feasible combination regimen promising nanoplatform development chemoimmunotherapy.

Language: Английский

Citations

23