Activating MoO₃ nanobelts via aqueous intercalation as a near‐infrared type I photosensitizer for photodynamic periodontitis treatment

SmartMat, Год журнала: 2023, Номер 4(6)

Опубликована: Сен. 13, 2023

Abstract Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy, chemodynamic and catalytic their utilization photosensitizers photodynamic therapy (PDT) rarely reported so far. Herein, we report the activation of MoO 3 nanobelts via aqueous co‐intercalation Na + H 2 O into van der Waals gaps a near‐infrared Type I photosensitizer periodontitis treatment. The /H intercalation can shorten its length, generate rich oxygen vacancies, enlarge interlayer gaps. Such structural changes thus induce color change from white to dark blue with strong (NIR) absorption. When used photosensitizer, I‐MoO 3− x exhibit much higher activities generation superoxide radical (·O − ) under an 808 nm laser irradiation than that pristine nanobelts. Therefore, prepared show spectral antibacterial activity Escherichia coli Saccharomyces aureus , yielding good clinical therapeutic effect on periodontitis. Our study proves be simple but powerful strategy activate layered high‐performance PDT.

Язык: Английский

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Redox Active Zn@MOFs as Spontaneous Reactive Oxygen Species Releasing Antimicrobials

Journal of the American Chemical Society, Год журнала: 2023, Номер 146(1), С. 599 - 608

Опубликована: Дек. 18, 2023

The rapid development of antimicrobial resistance (AMR) among infectious pathogens has become a major threat and challenge in healthcare systems globally. A strategy distinct from minimizing the overuse antimicrobials involves novel with mode action that prevents AMR microbial strains. Reactive oxygen species (ROS) are formed as natural byproduct cellular aerobic metabolism. However, it becomes pathological when ROS is produced at excessive levels. Exploiting this phenomenon, research on redox-active bactericides been demonstrated to be beneficial. Materials release via photodynamic, thermodynamic, photocatalytic interventions have developed nanomedicines used various applications. these materials require external stimuli for effective biocides. In paper, we report zinc-based metal organic framework (Zn@MOF) particles promote spontaneous active species. synthesized Zn@MOF spontaneously releases superoxide anions hydrogen peroxide, exhibiting potent efficacy against microbes. Zn@MOF-incorporated plastic films coatings show excellent, long-lasting potency even under continuous an aging process. These disinfecting surfaces maintain their properties after 500× surface wipes. also biocompatible safe skin, illustrating its broad potential applications medical technology consumer care

Язык: Английский

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Recent advances in two-dimensional nanomaterials for bone tissue engineering

Journal of Materiomics, Год журнала: 2023, Номер 9(5), С. 930 - 958

Опубликована: Март 31, 2023

Over the last decades, bone tissue engineering has increasingly become a research focus in field of biomedical engineering, which biomaterials play an important role because they can provide both biomechanical support and osteogenic microenvironment process regeneration. Among these biomaterials, two-dimensional (2D) nanomaterials have recently attracted considerable interest owing to their fantastic physicochemical biological properties including great biocompatibility, excellent capability, large specific surface area, outstanding drug loading capacity. In this review, we summarize state-of-the-art advances 2D for engineering. Firstly, introduce most explored used advantages. We then highlight cutting-edge such as graphene its derivatives, layered double hydroxides, black phosphorus, transition metal dichalcogenides, montmorillonite, hexagonal boron nitride, graphite phase carbon carbonitrides (MXenes) Finally, current challenges future prospects regeneration clinical translation are discussed.

Язык: Английский

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AIE donor-dependent photosensitizer for enhance photodynamic antibacterial interface

Surfaces and Interfaces, Год журнала: 2023, Номер 39, С. 102996 - 102996

Опубликована: Май 27, 2023

Язык: Английский

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Responsive metal–organic framework nanocarrier delivery system: An effective solution against bacterial infection

Coordination Chemistry Reviews, Год журнала: 2023, Номер 496, С. 215431 - 215431

Опубликована: Сен. 4, 2023

Язык: Английский

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Nanoporous {Pb₃}-Organic Framework for Catalytic Cycloaddition of CO₂ with Epoxides and Knoevenagel Condensation

ACS Applied Nano Materials, Год журнала: 2023, Номер 6(24), С. 23196 - 23206

Опубликована: Дек. 5, 2023

Because of increasingly serious environmental problems and resource shortages, chemically fixing surplus CO2 into value-added products has gradually become a challenging hot research topic, in which the preparation zeolite-like metal–organic frameworks (MOFs) with rich Lewis acid–base sites nanopores is cornerstone. Herein, butterfly-shaped [Pb3(COO)6(H2O)2(Npyridine)2] cluster, polynitro tritopic carboxylic acid 2,4,6-tri(4-carboxy-2-nitrophenyl)-1,3,5-trinitrobenzene (H3TCNT), 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine (TPT) engender highly robust microporous framework [Pb3(TCNT)2(TPT)(H2O)2]n (NUC-91) rectangular nanochannels (15.28 × 12.16 Å2) along b axis. extremely functional such as acidic Pb2+ ions basic free nitrogen atoms on inner surface void volumes, activated NUC-91a heterogeneous catalyst can effectively catalyze cycloaddition various epoxides under mild conditions. For substrates 2-methyloxirane, 2-fluorooxirane, 2-ethyloxirane, 2-(trifluoromethyl)oxirane, oxiran-2-ylmethanol, 2-vinyloxirane, 2-phenyloxirane, transformation to related cyclic carbonates could reach 99% turnover number (TON) frequency (TOF) 825 206 h–1, respectively. Moreover, Knoevenagel condensation reactions aldehydes malononitrile be efficiently effected by NUC-91a. Therefore, this work provided simple strategy for prefunctionalizing widely used ligands, employed design catalytic facilitate capture conversion CO2.

Язык: Английский

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Biophilic Positive Carbon Dot Exerts Antifungal Activity and Augments Corneal Permeation for Fungal Keratitis

Nano Letters, Год журнала: 2024, Номер 24(13), С. 4044 - 4053

Опубликована: Март 22, 2024

Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness conventional antifungal drugs limited due to intrinsic ocular barrier impedes drug absorption. There urgent need develop new therapeutic strategies effectively combat FK. Herein, we synthesized ultrasmall positively charged carbon dot using simple stage-melting method. The can penetrate corneal by opening tight junctions, allowing them reach lesion site and kill fungi. results both in vitro vivo demonstrated it exhibited good biocompatibility activity, significantly improving effect mouse model Therefore, this biophilic size positive dot, characterized its ability properties, may offer valuable insights into design effective nanomedicines.

Язык: Английский

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Dual-ROS-scavenging and dual-lingering nanozyme-based eye drops alleviate dry eye disease

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 8, 2024

Abstract Efficiently removing excess reactive oxygen species (ROS) generated by various factors on the ocular surface is a promising strategy for preventing development of dry eye disease (DED). The currently available drops DED treatment are palliative, short-lived and frequently administered due to short precorneal residence time. Here, we developed nanozyme-based exploiting borate-mediated dynamic covalent complexation between n-FeZIF-8 nanozymes (n-Z(Fe)) poly(vinyl alcohol) (PVA) overcome these problems. resultant formulation (PBnZ), which has dual-ROS scavenging abilities prolonged corneal retention can effectively reduce oxidative stress, thereby providing an excellent preventive effect alleviate DED. In vitro in vivo experiments revealed that PBnZ could eliminate ROS through both its multienzyme-like activity ROS-scavenging borate bonds. positively charged displayed longer time physical adhesion bonds phenyboronic acid PVA or o-diol with mucin. results showed These dual-function provide insights into novel strategies other ROS-mediated inflammatory diseases rationale application nanomaterials clinical settings. Graphical

Язык: Английский

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Applications of Metal–Organic Frameworks (MOFs) in Drug Delivery, Biosensing, and Therapy: A Comprehensive Review

Langmuir, Год журнала: 2024, Номер 40(43), С. 22477 - 22503

Опубликована: Окт. 17, 2024

The porous materials known as metal-organic frameworks (MOFs) stand out for their enormous surface area, adaptable pore size and shape, structural variety. These characteristics make them well-suited various applications, especially in healthcare. This review thoroughly summarizes recent studies on the use of MOFs drug delivery, biosensing, therapeutics. may encapsulate medications, target certain cells or tissues, regulate release over time. Additionally, have potential to be used biosensing allowing selective detection chemical biological substances. MOFs' optical electrical modified biosensors that track physiological data. show targeted delivery regulated therapeutic substances cancer treatment. In addition, they work potent antibacterial agents, providing a less dangerous option than traditional antibiotics increase antibiotic resistance. For practical further research is required well more consideration problems with toxicity biocompatibility. addition addressing difficulties promising possibilities this study intends provide insights into healthcare Despite several essential reviews it was necessary look most therapy combined concept.

Язык: Английский

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Emerging Violet Phosphorus Nanomaterial for Biomedical Applications

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Violet phosphorus (VP) is a allotrope first discovered by Hittorf in 1865, which has aroused more attention the biomedical field recent years attributed to its gradually unique properties. VP can be further categorized into bulk VP, nanosheets (VPNs), and quantum dots (VPQDs), chemical vapor transport (CVT), liquid‐phase/mechanical/laser exfoliation, solvothermal synthesis are common preparation approaches of VPNs, VPQDs, respectively. Compared with another (black phosphorus, BP) that once highly regarded applications, nanomaterial (namely VPNs VPQDs) not only exhibits tunable bandgap, moderate on/off current ratio, good biodegradability, but shows enhanced stability biosafety as well, allowing it promising candidate for variety applications like antibacterial therapy, anticancer biosensing disease diagnosis. In this review, classification relevant routes initially summarized, properties momentous subsequently expounded. The latest research advances emerging then introduced detail, both existing challenges future prospects also discussed.

Язык: Английский

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