Metal Complexes in Cancer Treatment: Journey So Far

Chemistry & Biodiversity, Год журнала: 2023, Номер 20(4)

Опубликована: Фев. 24, 2023

Abstract Metal complexes in cancer therapy have attracted much interest mainly because metals exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and bonding, Lewis acid properties etc . In 1965, Barnett Rosenberg serendipitously discovered the metal‐based compound cisplatin, an outstanding breakthrough history of anticancer led to a new area drug discovery. Many compounds been studied for their potential properties. Some these FDA approval clinical use, while others are now undergoing trials detection. present study, we highlighted primary mode action metallic all FDA‐approved/under trial drugs with reference treatment. This review also focuses on recent progress platinum, ruthenium, iron, activities.

Язык: Английский

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Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 514, С. 215941 - 215941

Опубликована: Май 18, 2024

Язык: Английский

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Circularly polarized luminescence and coordination geometries in mononuclear lanthanide(III) complexes

Coordination Chemistry Reviews, Год журнала: 2024, Номер 505, С. 215675 - 215675

Опубликована: Фев. 9, 2024

Язык: Английский

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Apoptotic cell death of stomach cancer lines (AGS) induced by Co-NTB complex through cellular organelles and DNA damage

RSC Advances, Год журнала: 2025, Номер 15(2), С. 739 - 747

Опубликована: Янв. 1, 2025

Given that stomach cancer is the fourth leading cause of cancer-related death, there a need to develop new drugs. Among various methods, metal-based coordination compounds are considered as an efficient strategy against this type cancer. Similarly, benzimidazole moiety plays crucial role in biology; thus, benzimidazole-based have been found be active potential anticancer drugs and currently used clinical trials. In study, we explored cobalt(ii) complex agent AGS cell lines. Interestingly, MTT assay Co-NTB shows lower IC

Язык: Английский

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Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7161 - 7181

Опубликована: Фев. 20, 2025

Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.

Язык: Английский

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Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

ChemMedChem, Год журнала: 2022, Номер 17(20)

Опубликована: Сен. 7, 2022

Abstract Although it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, not until 1917 during First World War and development mustard gas chemotherapy against became relevant; however, its properties were recognised 1946 to later be used patients. In this sense, use metallopharmaceuticals therapy extensively explored 1960s with discovery cisplatin anticancer activity. From date present, search for more effective, selective metallodrugs fewer side effects has been an area continuous exploration. Efforts have led considering a wide variety metals from periodic table, mainly d ‐block, as well organic ligands, preferably proven biological various research groups found ideal binder Schiff bases, since their raw materials are easily accessible, synthesis conditions friendly denticity can manipulated. Therefore, review, we antitumor activity reported literature coordination complexes ‐block coordinated tridentate bases (O N O N) derived salicylaldehyde. For work, main scientific databases CCDC® SciFinder®.

Язык: Английский

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Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 67(1), С. 691 - 708

Опубликована: Дек. 23, 2023

A second-generation series of biscyclometalated 2-(5-aryl-thienyl)-benzimidazole and -benzothiazole Ir(III) dppz complexes [Ir(C^N)2(dppz)]+, Ir1–Ir4, were rationally designed synthesized, where the aryl group attached to thienyl ring was p-CF3C6H4 or p-Me2NC6H4. These new assessed as photosensitizers explore structure–activity correlations for their potential use in biocompatible anticancer photodynamic therapy. When irradiated with blue light, exhibited high selective potency across several cancer cell lines predisposed therapy; benzothiazole derivatives (Ir1 Ir2) best performers, Ir2 being also activatable green red light. Notably, when irradiated, induced leakage lysosomal content into cytoplasm HeLa cells oncosis-like death. The capability Ir photoinduce death 3D spheroids has been demonstrated. investigated can catalytically photo-oxidate NADH photogenerate 1O2 and/or •OH cell-free media.

Язык: Английский

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Bis(benzimidazole) Complexes, Synthesis and Their Biological Properties: A Perspective

Inorganics, Год журнала: 2023, Номер 11(3), С. 113 - 113

Опубликована: Март 9, 2023

Benzimidazoles are a very well-known, broad group of compounds containing nitrogen atoms in their structure that can mimic properties DNA bases. The show not only biological activities but also used for spectral and catalytic properties. Biological activity benzimidazoles be tuned accelerated coordination compounds. This minireview is focused on preparation bis(benzimidazoles), complexes, found from 2015.

Язык: Английский

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Silver‐based Terpyridine Complexes as Antitumor Agents

Chemistry - A European Journal, Год журнала: 2023, Номер 29(37)

Опубликована: Март 16, 2023

Silver complexes bearing substituted terpyridine or tetra-2-pyridinylpyrazine ligands have been prepared and structurally characterised. The study of the anticancer properties silver with this type is scarce, despite possibilities combining metal ability for DNA binding. Here, antiproliferative activity, stability, CT-DNA binding, mechanism cell death these types derivatives are studied. High cytotoxicity against different tumour cells was observed, and, more important, a great selectivity index has detected between healthy lymphocytes T some compounds. interaction shown that able to interact by moderate intercalation. Furthermore, studies indicate promote apoptosis mitochondrial pathway.

Язык: Английский

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Coordination environment dependence of anticancer activity in cyclometalated bismuth(III) complexes with C,O-chelating ligands

Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 256, С. 112571 - 112571

Опубликована: Апрель 21, 2024

Язык: Английский

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