ACS Omega,
Год журнала:
2023,
Номер
8(10), С. 8925 - 8935
Опубликована: Март 1, 2023
In
recent
years,
mitochondrion
(powerhouse
of
the
cells)
gained
lots
interest
as
one
unorthodox
targets
for
futuristic
cancer
therapy.
As
a
result,
novel
small
molecules
were
developed
to
damage
and
image
mitochondria
in
models.
this
context,
aggregation-induced
emission
probes
(AIEgens)
received
immense
attention
due
their
applications
mitochondria-targeted
biosensing,
imaging,
biomedical
theranostics.
On
other
hand,
phototherapy
(photodynamic
photothermal)
has
emerged
powerful
alternative
manage
its
less
invasive
nature.
However,
merging
these
two
areas
engineer
phototherapeutic
diagnosis
treatment
remained
major
challenge.
mini-review,
we
will
outline
development
molecule
AIEgens
imaging
agents
photosensitizers
photodynamic
therapy
along
with
dual
photodymanic–phototheramal
chemo-photodynamic
We
also
highlight
current
challenges
developing
photothermal
future
theranostic
cancer.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(16), С. 5607 - 5651
Опубликована: Янв. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Abstract
Bacteria
can
cause
numerous
infectious
diseases
and
has
been
a
major
threat
to
human
humans.
Although
antibiotics
have
partially
succeeded
in
treating
bacteria,
owing
antibiotic
abuse,
the
emergence
of
multidrug‐resistant
(MDR)
bacteria
drastically
diminished
their
potency.
Since
invention
laser,
combination
light
photosensitizers,
photodynamic
therapy
(PDT),
become
an
effective
noninvasive
treatment
along
with
photothermal
(PTT),
which
heat
is
generated
by
nonradiative
relaxation.
Antimicrobial
PDT
PTT
are
emerging
as
treatments
for
bacterial
infection,
particularly
against
MDR
bacteria.
This
mini
review
covers
recent
progresses
treatment.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(18)
Опубликована: Фев. 19, 2024
The
cell
membrane
is
a
crucial
component
of
cells,
protecting
their
integrity
and
stability
while
facilitating
signal
transduction
information
exchange.
Therefore,
disrupting
its
structure
or
impairing
functions
can
potentially
cause
irreversible
damage.
Presently,
the
tumor
recognized
as
promising
therapeutic
target
for
various
treatment
methods.
Given
extensive
research
focused
on
membranes,
it
both
necessary
timely
to
discuss
these
developments,
from
materials
design
specific
biomedical
applications.
This
review
covers
treatments
based
functional
targeting
membrane,
ranging
well-known
membrane-anchoring
photodynamic
therapy
recent
lysosome-targeting
chimaeras
protein
degradation.
diverse
mechanisms
are
introduced
in
following
sections:
phototherapy,
self-assembly
situ
biosynthesis
degradation
proteins
by
chimeras.
In
each
section,
we
outline
conceptual
general
derived
numerous
studies,
emphasizing
representative
examples
understand
advancements
draw
inspiration.
Finally,
some
challenges
future
directions
membrane-targeted
our
perspective.
aims
engage
multidisciplinary
readers
encourage
researchers
related
fields
advance
fundamental
theories
practical
applications
membrane-targeting
agents.
