Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(17), С. 12087 - 12099
Опубликована: Апрель 22, 2024
Electron
transfer
during
solid–liquid
contact
electrification
has
been
demonstrated
to
produce
reactive
oxygen
species
(ROS)
such
as
hydroxyl
radicals
(•OH)
and
superoxide
anion
(•O2–).
Here,
we
show
that
a
process
also
occurs
in
liquid–liquid
electrification.
By
preparing
perfluorocarbon
nanoemulsions
construct
perfluorocarbon–water
"liquid–liquid"
interface,
confirmed
electrons
were
transferred
from
water
ultrasonication-induced
high-frequency
•OH
•O2–.
The
produced
ROS
could
be
applied
ablate
tumors
by
triggering
large-scale
immunogenic
cell
death
tumor
cells,
promoting
dendritic
maturation
macrophage
polarization,
ultimately
activating
T
cell-mediated
antitumor
immune
response.
Importantly,
the
raw
material
for
producing
is
water,
so
therapy
not
limited
endogenous
substances
(O2,
H2O2,
etc.)
microenvironment.
This
work
provides
new
perspectives
elucidating
mechanism
of
generation
free
an
excellent
therapeutic
modality.
Abstract
Despite
the
advent
of
various
medical
interventions
for
cancer
treatment,
disease
continues
to
pose
a
formidable
global
health
challenge,
necessitating
development
new
therapeutic
approaches
more
effective
treatment
outcomes.
Photodynamic
therapy
(PDT),
which
utilizes
light
activate
photosensitizer
produce
cytotoxic
reactive
oxygen
species
(ROS)
eradicating
cells,
has
emerged
as
promising
approach
due
its
high
spatiotemporal
precision
and
minimal
invasiveness.
However,
widespread
clinical
use
PDT
faces
several
challenges,
including
inefficient
production
ROS
in
hypoxic
tumor
microenvironment,
limited
penetration
depth
biological
tissues,
inadequate
accumulation
photosensitizers
at
site.
Over
past
decade,
there
been
increasing
interest
utilization
photofunctional
transition
metal
complexes
applications
their
intriguing
photophysical
photochemical
properties.
This
review
provides
an
overview
current
design
strategies
used
innovative
phototherapeutics,
aiming
address
limitations
associated
with
achieve
The
challenges
future
perspectives
on
translation
are
also
discussed.
Biomacromolecules,
Год журнала:
2024,
Номер
25(4), С. 2302 - 2311
Опубликована: Март 20, 2024
Photodynamic
therapy
(PDT)
employs
photosensitizers
to
convert
nearby
oxygen
into
toxic
singlet
(1O2)
upon
laser
light
irradiation,
showing
great
potential
as
a
noninvasive
approach
for
tumor
ablation.
However,
the
therapeutic
efficacy
of
PDT
is
essentially
impeded
by
π–π
stacking
and
aggregation
photosensitizers.
Herein,
we
propose
microenvironment-triggered
self-adaptive
nanoplatform
weaken
selenium-based
oxidation
at
site.
The
selenide
units
in
porphyrin-containing
amphiphilic
copolymer
(PSe)
could
be
oxidized
hydrophilic
selenoxide
units,
leading
self-expansion
stretching
distance
between
intramolecular
porphyrin
units.
This
process
provide
better
switch
greatly
reduce
photosensitive
generating
more
1O2
irradiation.
As
verified
series
vitro
vivo
studies,
PSe
efficiently
self-adapted
sites,
thus
significantly
enhancing
effect
against
solid
tumors
minimizing
side
effects.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(17), С. 12087 - 12099
Опубликована: Апрель 22, 2024
Electron
transfer
during
solid–liquid
contact
electrification
has
been
demonstrated
to
produce
reactive
oxygen
species
(ROS)
such
as
hydroxyl
radicals
(•OH)
and
superoxide
anion
(•O2–).
Here,
we
show
that
a
process
also
occurs
in
liquid–liquid
electrification.
By
preparing
perfluorocarbon
nanoemulsions
construct
perfluorocarbon–water
"liquid–liquid"
interface,
confirmed
electrons
were
transferred
from
water
ultrasonication-induced
high-frequency
•OH
•O2–.
The
produced
ROS
could
be
applied
ablate
tumors
by
triggering
large-scale
immunogenic
cell
death
tumor
cells,
promoting
dendritic
maturation
macrophage
polarization,
ultimately
activating
T
cell-mediated
antitumor
immune
response.
Importantly,
the
raw
material
for
producing
is
water,
so
therapy
not
limited
endogenous
substances
(O2,
H2O2,
etc.)
microenvironment.
This
work
provides
new
perspectives
elucidating
mechanism
of
generation
free
an
excellent
therapeutic
modality.
