Free Radicals Generated in Perfluorocarbon–Water (Liquid–Liquid) Interfacial Contact Electrification and Their Application in Cancer Therapy DOI
Haimei Li, Zichen Wang, Xu Chu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(17), P. 12087 - 12099

Published: April 22, 2024

Electron transfer during solid–liquid contact electrification has been demonstrated to produce reactive oxygen species (ROS) such as hydroxyl radicals (•OH) and superoxide anion (•O2–). Here, we show that a process also occurs in liquid–liquid electrification. By preparing perfluorocarbon nanoemulsions construct perfluorocarbon–water "liquid–liquid" interface, confirmed electrons were transferred from water ultrasonication-induced high-frequency •OH •O2–. The produced ROS could be applied ablate tumors by triggering large-scale immunogenic cell death tumor cells, promoting dendritic maturation macrophage polarization, ultimately activating T cell-mediated antitumor immune response. Importantly, the raw material for producing is water, so therapy not limited endogenous substances (O2, H2O2, etc.) microenvironment. This work provides new perspectives elucidating mechanism of generation free an excellent therapeutic modality.

Language: Английский

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics DOI Creative Commons
Lawrence Cho‐Cheung Lee, Kenneth Kam‐Wing Lo

Small Methods, Journal Year: 2024, Volume and Issue: 8(11)

Published: Sept. 25, 2024

Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.

Language: Английский

Citations

6
Tumor Microenvironment-Triggered Self-Adaptive Polymeric Photosensitizers for Enhanced Photodynamic Therapy DOI

Zepeng Cui,

Ruqian Ji,

Jun Xie

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2302 - 2311

Published: March 20, 2024

Photodynamic therapy (PDT) employs photosensitizers to convert nearby oxygen into toxic singlet (1O2) upon laser light irradiation, showing great potential as a noninvasive approach for tumor ablation. However, the therapeutic efficacy of PDT is essentially impeded by π–π stacking and aggregation photosensitizers. Herein, we propose microenvironment-triggered self-adaptive nanoplatform weaken selenium-based oxidation at site. The selenide units in porphyrin-containing amphiphilic copolymer (PSe) could be oxidized hydrophilic selenoxide units, leading self-expansion stretching distance between intramolecular porphyrin units. This process provide better switch greatly reduce photosensitive generating more 1O2 irradiation. As verified series vitro vivo studies, PSe efficiently self-adapted sites, thus significantly enhancing effect against solid tumors minimizing side effects.

Language: Английский

Citations

5
The synthesis and therapeutic effect of silicon(IV) phthalocyanines for colorectal cancer cells in photodynamic therapy by altering Wnt/β-catenin and apoptotic signaling DOI
Burak Barut, Elif Nur Barut, Can Özgür Yalçın

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 453, P. 115663 - 115663

Published: April 8, 2024

Language: Английский

Citations

5
Revolutionizing anticancer treatment: Ruthenium-based nanoplatforms pave new paths DOI
Dipanjan Karati,

Shreyasi Meur,

Swarupananda Mukherjee

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216118 - 216118

Published: July 30, 2024

Language: Английский

Citations

5
Free Radicals Generated in Perfluorocarbon–Water (Liquid–Liquid) Interfacial Contact Electrification and Their Application in Cancer Therapy DOI
Haimei Li, Zichen Wang, Xu Chu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(17), P. 12087 - 12099

Published: April 22, 2024

Electron transfer during solid–liquid contact electrification has been demonstrated to produce reactive oxygen species (ROS) such as hydroxyl radicals (•OH) and superoxide anion (•O2–). Here, we show that a process also occurs in liquid–liquid electrification. By preparing perfluorocarbon nanoemulsions construct perfluorocarbon–water "liquid–liquid" interface, confirmed electrons were transferred from water ultrasonication-induced high-frequency •OH •O2–. The produced ROS could be applied ablate tumors by triggering large-scale immunogenic cell death tumor cells, promoting dendritic maturation macrophage polarization, ultimately activating T cell-mediated antitumor immune response. Importantly, the raw material for producing is water, so therapy not limited endogenous substances (O2, H2O2, etc.) microenvironment. This work provides new perspectives elucidating mechanism of generation free an excellent therapeutic modality.

Language: Английский

Citations

4