Composites Part B Engineering, Год журнала: 2024, Номер 282, С. 111566 - 111566
Опубликована: Май 17, 2024
Язык: Английский
Bone Research, Год журнала: 2022, Номер 10(1)
Опубликована: Фев. 23, 2022
Abstract Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts two main traditional remedies, but they can cause a series of complications. To address this problem, researchers have constructed various implantable biomaterials. However, the original pathological microenvironment defects, such as residual severe infection, diseases, could further affect regeneration. Thus, rational design versatile biomaterials integrated therapy regeneration functions is great demand. Many strategies been applied to fabricate smart stimuli-responsive materials for regeneration, stimuli related external physical triggers endogenous disease microenvironments involving multiple strategies. Typical include light irradiation, electric magnetic fields, ultrasound, mechanical stimuli. These transform internal atomic packing arrangements cell fate, thus enhancing tissue In addition strategy, some specific microenvironments, excess reactive oxygen species mild acidity pH reduction enzymes secreted by bacteria electronegative potential defect sites, be used biochemical activate Herein, we summarize discuss construction therapeutic regenerative functions. The mechanisms, applications, existing limitations newly designed also clarified.
Язык: Английский
Процитировано
272
Advanced Science, Год журнала: 2022, Номер 9(13)
Опубликована: Март 10, 2022
Abstract Wound dressing with the capacities of antioxidation, antiinflammation, and efficient angiogenesis induction is expected for effectively promoting wound healing. Herein, a novel core‐shell hyaluronic acid (HA) microneedle (MN) patch ferrum‐mesenchymal stem cell‐derived artificial nanovesicles (Fe‐MSC‐NVs) polydopamine nanoparticles (PDA NPs) encapsulated in needle tips presented Fe‐MSC‐NVs containing multifunctional therapeutic cytokines are inner HA core MN accelerating angiogenesis. The PDA NPs outer methacrylated (HAMA) shell to overcome adverse impacts from reactive oxygen species (ROS)‐derived oxidative stress. With gradual degradation HAMA skin, sustainably released at lesion suppress ROS‐induced inflammation reaction, while significantly increase migration, proliferation, tube formation human umbilical vein endothelial cells (HUVEC). More attractively, combination further promotes M2 macrophage polarization, thereby suppressing inflammation. Through vivo experiment, Fe‐MSC‐NVs/PDA shows an excellent effect diabetic These features pro‐angiogenesis indicate proposed composite valuable clinical healing applications.
Язык: Английский
Процитировано
235
Coordination Chemistry Reviews, Год журнала: 2023, Номер 488, С. 215153 - 215153
Опубликована: Апрель 27, 2023
Язык: Английский
Процитировано
84
Theranostics, Год журнала: 2023, Номер 13(3), С. 931 - 954
Опубликована: Янв. 1, 2023
Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and chronic inflammation, involving multiple cellular dysfunctions tissue lesions.The non-vascular environment dense matrix in the joints tend to block drug penetration, resulting low bioavailability.There desire develop safer more effective OA therapies meet challenges an aging world population future.Biomaterials have achieved satisfactory results improving targeting, prolonging duration action, achieving precision therapy.This article reviews current basic understanding pathological mechanisms clinical treatment dilemmas OA, summarizes discusses advances for different kinds targeted responsive biomaterials seeking provide new perspectives OA.Subsequently, limitations translation biosafety are analyzed guide development future therapeutic strategies OA.As need medicine rises over time, emerging multifunctional based on targeting controlled release will become irreplaceable part management.
Язык: Английский
Процитировано
68
Biomaterials, Год журнала: 2023, Номер 295, С. 122030 - 122030
Опубликована: Янв. 31, 2023
Язык: Английский
Процитировано
51
Advanced Materials, Год журнала: 2024, Номер 36(18)
Опубликована: Янв. 15, 2024
Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.
Язык: Английский
Процитировано
29
Polymers, Год журнала: 2024, Номер 16(19), С. 2755 - 2755
Опубликована: Сен. 29, 2024
Polyvinyl alcohol (PVA)-based hydrogels have attracted significant attention due to their excellent biocompatibility, tunable mechanical properties, and ability form stable three-dimensional networks. This comprehensive review explores the recent advancements in PVA-based hydrogels, focusing on unique fabrication strategies, multifunctional applications. Firstly, it discusses various facile synthesis techniques, including freeze/thaw cycles, chemical cross-linking, enhancement which led enhanced strength, elasticity, responsiveness external stimuli. These improvements expanded applicability of critical areas such as biomedical, environmental treatment, flexible electronics, civil engineering, well other emerging Additionally, integration smart functionalities, self-healing capabilities multi-responsiveness, is also examined. Despite progress, challenges remain, optimizing stability under varying conditions addressing potential toxicity cross-linkers. The concludes by outlining future perspectives, emphasizing fields like regenerative medicine, sustainability, advanced manufacturing. It underscores importance interdisciplinary collaboration realizing full these versatile materials address pressing societal challenges.
Язык: Английский
Процитировано
28
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
The activation of pro-inflammatory M1-type macrophages by overexpression reactive oxygen species (ROS) and nitrogen (RONS) in synovial membranes contributes to osteoarthritis (OA) progression cartilage matrix degradation. Here, combing Pt Se with potent catalytic activities, we developed a hybrid Pt–Se nanozymes as ROS RONS scavengers exert synergistic effects for OA therapy. As result, exhibited efficient scavenging effect on levels, leading repolarization macrophages. Furthermore, the polarization M2 phenotype inhibited expression factors salvaged mitochondrial function arthritic chondrocytes. In vivo results also suggest that effectively suppress early an Osteoarthritis Research International Association score reduction 68.21% 82.66% 4 8 weeks, respectively. conclusion, this study provides promising strategy regulate inflammatory responses macrophage processes therapeutic.
Язык: Английский
Процитировано
19
Materials Horizons, Год журнала: 2023, Номер 10(7), С. 2554 - 2567
Опубликована: Янв. 1, 2023
It is found that a cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system can effectively treat early OA through synergistic lubrication, dual-drug sequence controlled release, and anti-inflammation.
Язык: Английский
Процитировано
34
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(12)
Опубликована: Янв. 28, 2023
Abstract Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response joint capsule. Synergistic therapy combining anti‐inflammation emerges as a novel treatment OA. In this study, bioinspired by ultralow friction natural synovial fluid mussel adhesion chemistry, biomimetic nanosystem dual functions enhanced stimuli‐responsive drug release developed. A dopamine mediated strategy realizes one step grafting hyaluronic acid (HA) on fluorinated graphene. The polymer modified sheets exhibit highly efficient near‐infrared absorption, show steady long time under various working conditions, in which the coefficient reduced 75% compared to H 2 O. Diclofenac sodium (DS) high loading capacity 29.2% controllably loaded, responsive sustained adjusted light. Cell experiments reveal that lubricating taken up endocytosis, results confirm inhibits osteoarthritis deterioration upregulating anabolic gene downregulating catabolic proteases pain‐related gene. This work proposes promising approach integrate graphene dual‐functional for effective synergistic
Язык: Английский
Процитировано
29