Polymer Applied in Hydrogel Wound Dressing for Wound Healing: Modification/Functionalization Method and Design Strategies

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Hydrogel wound dressings have emerged as a promising solution for healing due to their excellent mechanical and biochemical properties. Over recent years, there has been significant progress in expanding the variety of raw materials used hydrogel formulation along with development advanced modification techniques design approaches that enhance performance. However, comprehensive review encompassing diverse polymer strategies innovations is still lacking literature. This summarizes use natural polymers (e.g., chitosan, gelatin, sodium alginate, hyaluronic acid, dextran) synthetic poly(vinyl alcohol), polyethylene glycol, Pluronic F-127, poly(N-isopropylacrylamide), polyacrylamide, polypeptides) dressings. We further explore advantages limitations these discuss various strategies, including cationic modification, oxidative double-bond catechol etc. The also addresses principles synthesis methods, aligning modifications specific requirements healing. Finally, we future challenges opportunities hydrogel-based

Язык: Английский

---

Facile preparation of polyphenol-crosslinked chitosan-based hydrogels for cutaneous wound repair

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 228, С. 99 - 110

Опубликована: Дек. 21, 2022

Язык: Английский

---

Ultra-stretchable, tissue-adhesive, shape-adaptive, self-healing, on-demand removable hydrogel dressings with multiple functions for infected wound healing in regions of high mobility

Acta Biomaterialia, Год журнала: 2023, Номер 166, С. 224 - 240

Опубликована: Май 18, 2023

Язык: Английский

---

Preparation and Application of Hemostatic Hydrogels

Small, Год журнала: 2023, Номер 20(22)

Опубликована: Дек. 15, 2023

Hemorrhage remains a critical challenge in various medical settings, necessitating the development of advanced hemostatic materials. Hemostatic hydrogels have emerged as promising solutions to address uncontrolled bleeding due their unique properties, including biocompatibility, tunable physical characteristics, and exceptional capabilities. In this review, comprehensive overview preparation biomedical applications is provided. Particularly, with materials forms are introduced. Additionally, trauma management, surgical procedures, wound care, etc. summarized. Finally, limitations future prospects discussed evaluated. This review aims highlight hemorrhage management offer insights into clinically relevant

Язык: Английский

---

Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(39), С. 45676 - 45688

Опубликована: Сен. 21, 2023

Adhesives with robust but readily detachable wet tissue adhesion are of great significance for wound closure. Polyelectrolyte complex adhesive (PECA) is an important adhesive. However, its relatively weak cohesive and strength cannot satisfy clinical applications. Herein, modified tannic acid (mTA) a catechol group, long alkyl hydrophobic chain, phenyl group was prepared first, then, it mixed acrylic (AA) polyethylenimine (PEI), followed by UV photopolymerization to make hydrogel tough cohesion strength. The has strong interfacial toughness ∼1552 J/m2, good mechanical properties (∼7220 kPa strength, ∼873% strain, ∼33,370 kJ/m3 toughness), bursting pressure ∼1575 mmHg on porcine skin. can realize quick effective various biological tissues including skin, liver, kidney, heart be changed easily triggering urea solution avoid damage or uncomfortable pain the patient. This biosafe very promising closure may provide new ideas design adhesives.

Язык: Английский

---

Strong, self-healing, shape memory PAA-PANI/PVA/PDA/AOP conductive hydrogels with interpenetrating network and hydrogen bond interaction

European Polymer Journal, Год журнала: 2023, Номер 191, С. 112034 - 112034

Опубликована: Март 27, 2023

Язык: Английский

---

In Situ Formation of Conductive Epidermal Electrodes Using a Fully Integrated Flexible System and Injectable Photocurable Ink

ACS Nano, Год журнала: 2023, Номер 17(11), С. 10689 - 10700

Опубликована: Май 16, 2023

In situ fabrication of wearable devices through coating approaches is a promising solution for the fast deployment and more adaptable different sensing demands. However, heat, solvent, mechanical sensitivity biological tissues, along with personal compliance, pose strict requirements materials methods. To address this, biocompatible biodegradable light-curable conductive ink an all-in-one flexible system that conducts in injection photonic curing as well monitoring biophysiological information have been developed. The can be solidified spontaneous phase changes cured to achieve high strength 7.48 MPa excellent electrical conductivity 3.57 × 105 S/m. contains elastic chambers embedded specially designed optical waveguides uniformly dissipate visible LED light throughout rapidly cure 5 min. resulting electrodes offer intimate skin contact even existence hair work stably under acceleration 8 g, leading robust capable working intense motion, heavy sweating, varied surface morphology. Similar concepts may lead various deployable systems adaptability demands health tracking large populations.

Язык: Английский

---

Temperature-sensitive multifunctional intelligent responsive hydrogel based on carboxymethyl agarose and N-isopropylacrylamide: Controlled drug release and accelerated wound healing

Carbohydrate Polymers, Год журнала: 2023, Номер 322, С. 121327 - 121327

Опубликована: Сен. 4, 2023

Язык: Английский

---

A TA/Cu2+ Nanoparticle Enhanced Carboxymethyl Chitosan-Based Hydrogel Dressing with Antioxidant Properties and Promoting Wound Healing

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 231 - 245

Опубликована: Янв. 1, 2024

Background: As the first line of immune defense and largest organ body, skin is vulnerable to damage caused by surgery, burns, collisions other factors. Wound healing in a long complex physiological process that influenced number different Proper wound care can greatly improve speed reduce generation scars. However, traditional dressings (bandages, gauze, etc.) often used clinical practice have single function, lack active ingredients are limited use. Hydrogels with three-dimensional network structure potential biomedical material because their physical chemical environment similar extracellular matrix. In particular, hydrogel low price, good biocompatibility, degradability, antibacterial angiogenic activity favored public. Methods: Here, carboxymethyl chitosan-based dressing (CMCS-TA/Cu 2+ ) reinforced copper ion crosslinked tannic acid (TA/Cu nanoparticles was developed. This study investigated characteristics, cytotoxicity, angiogenesis TA/Cu CMCS-TA/Cu hydrogels. Furthermore, full-thickness defect model employed assess vivo capacity dressings. Results: The introduction not only could increase mechanical properties but also continuously releases ions promote cell migration (the reach 92% at 48 h) tubule formation, remove free radicals (repair rate 90% 9 days). Conclusion: Experiments proved has cytocompatibility, antioxidant ability, providing an advantageous solution for repair. Keywords: nanoparticles, chitosan, dressing,

Язык: Английский

---

Recent advances in wet surface tissue adhesive hydrogels for wound treatment

European Polymer Journal, Год журнала: 2024, Номер 216, С. 113260 - 113260

Опубликована: Июнь 24, 2024

Язык: Английский

---