Research Progress in Hydrogels for Cartilage Organoids

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Май 21, 2024

The repair and regeneration of cartilage has always been a hot topic in medical research. Cartilage organoids (CORGs) are special tissue created using engineering techniques outside the body. These engineered tissues provide models that simulate complex biological functions cartilage, opening new possibilities for regenerative medicine treatment strategies. However, it is crucial to establish suitable matrix scaffolds cultivation CORGs. In recent years, utilizing hydrogel culture stem cells induce their differentiation into chondrocytes emerged as promising method vitro construction this review, methods establishing CORGs summarized an overview advantages limitations matrigel such provided. Furthermore, importance ECM alternative substitutes Matrigel, alginate, peptides, silk fibroin, DNA derivatives discussed, pros cons these hydrogels outlined. Finally, challenges future directions research discussed. It hoped article provides valuable references design development

Язык: Английский

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Hydroxypropyl chitosan/ε-poly-l-lysine based injectable and self-healing hydrogels with antimicrobial and hemostatic activity for wound repair

Carbohydrate Polymers, Год журнала: 2024, Номер 337, С. 122135 - 122135

Опубликована: Апрель 7, 2024

Язык: Английский

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Hemostasis Strategies and Recent Advances in Hydrogels for Managing Uncontrolled Hemorrhage

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Hemorrhage continues to pose a significant challenge in various medical contexts, underscoring the need for advanced hemostatic materials. Hemostatic hydrogels have gained recognition as innovative tools addressing uncontrollable bleeding, attributed their distinctive features including biological compatibility, tunable mechanical properties, and exceptional performance. This review provides comprehensive overview of that offer rapid effective bleeding control. Particularly, this focuses on hydrogel design associated mechanisms. Additionally, recent advancements application these materials are discussed detail, especially clinical trials. Finally, challenges potential analyzed assessed. seeks emphasize role biomedical applications hemorrhage control provide perspectives innovation clinically applicable

Язык: Английский

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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency

Engineered Regeneration, Год журнала: 2024, Номер 5(1), С. 111 - 123

Опубликована: Янв. 14, 2024

The use of antibacterial dressings is crucial in the prevention and treatment wound infection emergency situations. However, efficacy compromised by long-term storage or exposure to harsh conditions. Here, an ultrastable in-situ silver nanoparticle dressing (AgSNP@CD) was prepared for effective emergency. fabrication process AgSNP@CD simple, suitable large-scale production. Due strong interaction between synthesized AgNPs cotton fabric, owned remarkable stability, thus retaining its antimicrobial even after (up 2 years) under extreme conditions (damp heat, low temperatures, low-oxygen, water immersion, acid-alkali erosion). Both vitro vivo results demonstrated extraordinary stability AgSNP@CD, facilitating healing In particular, exhibited a superior effect on severe bacteria-infected trauma can prevent occurrence sepsis effectively. exceptional complex make it well-suited strategy

Язык: Английский

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Chitosan catechol-tannic acid composite hydrogel and cryogel with antimicrobial and hemostatic properties

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132174 - 132174

Опубликована: Май 13, 2024

Язык: Английский

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Glucose-triggered NIR-responsive photothermal antibacterial gelatin/dextran hydrogel simultaneously targeting the high glucose and infection microenvironment in diabetic wound

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140325 - 140325

Опубликована: Янв. 1, 2025

Язык: Английский

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Naturally derived hydrogels for wound healing

Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Янв. 27, 2025

Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity excellent biocompatibility create an ideal moist environment for healing, thereby enhancing cell proliferation tissue regeneration. For this reason, naturally derived formulated from biomaterials such as chitosan, alginate, gelatin, fibroin are highly promising biodegradability low immunogenic responses. Recent integrated approaches utilizing new technologies with bioactive agents significantly improved the mechanical properties of controlled release delivery active compounds, efficiency treatment processes. Herein, review highlights advantages challenges focusing on strength, degradation rates, safety validation, potential incorporating advanced engineering gene therapy utilization personalized medicine.

Язык: Английский

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Green synthesis-inspired antibacterial, antioxidant and adhesive hydrogels with ultra-fast gelation and hemostasis for promoting infected skin wound healing

Acta Biomaterialia, Год журнала: 2024, Номер 184, С. 156 - 170

Опубликована: Июнь 17, 2024

Язык: Английский

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Metal‐coordinated amino acid/peptide/protein‐based supramolecular self‐assembled nanomaterials for anticancer applications

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Abstract Biomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile innovative nanoagents due to their structure‒function control, biological nature, simple preparation methods. This review article summarized the recent developments in multicomponent formed from metal interactions amino acids, peptides, proteins, together anticancer drugs, theranostics. We discussed role of functional groups anchored building blocks interactions, subsequently, types were examined a perspective. Amino acids different drugs forming mechanisms highlighted. Peptides proteins used material formations, activity discussed. Ultimately, conclusion future outlook offer fundamental fabrication design precision medicine.

Язык: Английский

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Enhancing Wound Recovery: A Self-Gelling Powder for Improved Hemostasis and Healing

Polymers, Год журнала: 2024, Номер 16(13), С. 1795 - 1795

Опубликована: Июнь 25, 2024

A novel self-gelatinizing powder was designed to accelerate wound healing through enhanced hemostasis and tissue recovery. Significantly, this research addresses the critical need for innovative management solutions by presenting a approach. Carboxymethylcellulose calcium (CMC-Ca) synthesized using an ion exchange method, lysine (Lys) integrated physical mixing augment material’s functional characteristics. The prepared underwent comprehensive evaluation its self-gelling capacity, gelation time, adhesion, swelling rate, coagulation efficiency, hemostatic effectiveness, promotion. Results indicate that exhibited remarkable water absorption capabilities, absorbing liquid up 30 times weight achieving rapid within 3 min. inclusion of Lys notably powder’s gel-forming properties. time determined be 4 s rotational rheometer, with rapidly forming stable gel on skin surface. Furthermore, in mouse injury model, near-complete recovery observed 14 days, underscoring impressive self-healing attributes promising application prospects management.

Язык: Английский

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