Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy

Advanced Science, Год журнала: 2023, Номер 11(2)

Опубликована: Ноя. 7, 2023

Abstract The treatment of bone defects remains a substantial clinical challenge due to the lack spatiotemporal management immune microenvironment, revascularization, and osteogenic differentiation. Herein, deferoxamine (DFO)‐loaded black phosphorus nanosheets decorated by polydopamine layer are prepared (BPPD) compounded into gelatin methacrylate/sodium alginate methacrylate (GA) hybrid hydrogel as smart‐responsive therapeutic system (GA/BPPD) for accelerated regeneration. BPPD nanocomposites served bioactive components near‐infrared (NIR) photothermal agents, which conferred with excellent NIR/pH dual‐responsive properties, realizing stimuli‐responsive release DFO PO 4 3 − during Under action NIR‐triggered mild therapy, GA/BPPD exhibited positive effect on promoting osteogenesis angiogenesis, eliminating excessive reactive oxygen species, inducing macrophage polarization M2 phenotype. More significantly, through polarization‐induced osteoimmune this platform could also drive functional cytokine secretion enhanced angiogenesis osteogenesis. In vivo experiments further demonstrated that facilitate healing attenuating local inflammatory response, increasing pro‐healing factors, stimulating endogenous cell recruitment, accelerating revascularization. Collectively, proposed intelligent provides promising strategy reshape damaged tissue microenvironment augmented

Язык: Английский

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Intelligent biobased hydrogels for diabetic wound healing: A review

Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149493 - 149493

Опубликована: Фев. 10, 2024

Язык: Английский

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Hyaluronidase‐Responsive Bactericidal Cryogel for Promoting Healing of Infected Wounds: Inflammatory Attenuation, ROS Scavenging, and Immune Regulation

Advanced Science, Год журнала: 2024, Номер 11(17)

Опубликована: Фев. 13, 2024

Abstract Wounds infected with multidrug‐resistant (MDR) bacteria are increasingly threatening public health and challenging clinical treatments because of intensive bacterial colonization, excessive inflammatory responses, superabundant oxidative stress. To overcome this malignant burden promote wound healing, a multifunctional cryogel (HA/TA2/KR2) composed hyaluronic acid (HA), tannic (TA), KR‐12 peptides is designed. The exhibited excellent shape‐memory properties, strong absorption performance, hemostatic capacity. In vitro experiments demonstrated that in the can be responsively released by stimulation hyaluronidase produced bacteria, reaching robust antibacterial activity against Escherichia coli ( E. coli) , MDR Pseudomonas aeruginosa (MDR‐PA), methicillin‐resistant Staphylococcus aureus (MRSA) disrupting cell membranes. Furthermore, synergetic effect TA efficiently scavenge ROS decrease expression pro‐inflammatory cytokines (tumor necrosis factor (TNF)‐α & interleukin (IL)−6), as well modulate macrophage phenotype toward M2 type. vivo animal tests indicated effectively destroy healing process via accelerating angiogenesis re‐epithelialization. Proteomic analysis revealed underlying mechanism which mainly reshaped microenvironment inhibiting Nuclear kappa B (NF‐κB) signaling pathway activating Janus kinase‐Signal transducer activator transcription (JAK‐STAT6) pathway. Therefore, HA/TA2/KR2 promising dressing candidate for bacteria‐infected healing.

Язык: Английский

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Antioxidative bioactive glass reinforced injectable hydrogel with reactive oxygen species scavenging capacity for diabetic wounds treatment

Chemical Engineering Journal, Год журнала: 2024, Номер 481, С. 148768 - 148768

Опубликована: Янв. 18, 2024

Язык: Английский

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A pH responsive tannic acid/quaternized carboxymethyl chitosan/oxidized sodium alginate hydrogels for accelerated diabetic wound healing and real-time monitoring

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130741 - 130741

Опубликована: Март 7, 2024

Язык: Английский

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A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(8), С. 9749 - 9767

Опубликована: Фев. 15, 2024

The treatment of diabetic chronic wounds is still faced with great challenges, mainly due to wound infection, excessive inflammation, and peripheral vascular disease in the area. Therefore, it importance develop a novel multifunctional hydrogel high efficiency accelerate healing. Curcumin (Cur), Chinese herbal, has shown potential enhancing healing because its immunomodulatory pro-angiogenic properties. However, low aqueous solubility, poor bioavailability, chemical instability have limited clinical applications. To address these current bottlenecks, poly(vinyl alcohol) (PVA)–chitosan (CS)/sodium alginate (SA)–Cur (PCSA) hydrogels were prepared for first time, they demonstrated all above intriguing performances by Michael addition reaction CS Cur. PCSA show multiple dynamic bonds, which possess strong mechanical properties (tensile stress: ∼0.980 MPa; toughness: ∼258.45 kJ/m3; compressive strength: ∼7.38 MPa at strain 80%). These provided an optimal microenvironment cell migration proliferation also promoted growth blood vessels, leading early angiogenesis. Importantly, experimental results that can effectively transform pro-inflammatory M1 macrophages into anti-inflammatory M2 without need additional ingredients vitro. Benefiting from characteristics, full-thickness rat model via ROS-scavenging, downregulation IL-1β, upregulation CD31 expression, resulting angiogenesis collagen deposition. This strategy not only provides simple safe Cur-based but highlights significant development high-performance biomaterials promoting using traditional medicine.

Язык: Английский

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Multifunctional PDA/ZIF8 based hydrogel dressing modulates the microenvironment to accelerate chronic wound healing by ROS scavenging and macrophage polarization

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150632 - 150632

Опубликована: Март 24, 2024

Язык: Английский

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Antibacterial adhesive based on oxidized tannic acid-chitosan for rapid hemostasis

Carbohydrate Polymers, Год журнала: 2024, Номер 333, С. 121973 - 121973

Опубликована: Фев. 22, 2024

Язык: Английский

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Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis

Theranostics, Год журнала: 2024, Номер 14(10), С. 4014 - 4057

Опубликована: Янв. 1, 2024

Background:The comprehensive management of diabetic bone defects remains a substantial clinical challenge due to the hostile regenerative microenvironment characterized by aggravated inflammation, excessive reactive oxygen species (ROS), bacterial infection, impaired angiogenesis, and unbalanced homeostasis.Thus, an advanced multifunctional therapeutic platform capable simultaneously achieving immune regulation, elimination, tissue regeneration is urgently designed for augmented under pathological milieu.Methods Results: Herein, photoactivated soft-hard combined scaffold system (PGCZ) was engineered introducing polydopamine-modified zeolitic imidazolate framework-8-loaded double-network hydrogel (soft matrix component) into 3D-printed poly(ε-caprolactone) (PCL) (hard component).The versatile PGCZ based on PCL thus prepared features highly extracellular matrix-mimicking microstructure, suitable biodegradability mechanical properties, excellent photothermal performance, allowing long-term structural stability support regeneration.Under periodic near-infrared (NIR) irradiation, localized effect triggers on-demand release Zn 2+ , which, together with repeated mild hyperthermia, collectively accelerates proliferation osteogenic differentiation preosteoblasts potently inhibits growth biofilm formation.Additionally, also presents outstanding immunomodulatory ROS scavenging capacities, which regulate M2 polarization macrophages drive functional cytokine secretion, leading pro-regenerative in situ enhanced vascularization.In vivo experiments further demonstrated that conjunction activity remarkably attenuated local inflammatory cascade, initiated endogenous stem cell recruitment neovascularization, orchestrated osteoblast/osteoclast balance, ultimately accelerating regeneration. Ivyspring

Язык: Английский

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A Photo‐induced Cross‐Linking Enhanced A and B Combined Multi‐Functional Spray Hydrogel Instantly Protects and Promotes of Irregular Dynamic Wound Healing

Small, Год журнала: 2024, Номер 20(23)

Опубликована: Март 10, 2024

Abstract Wounds in harsh environments can face long‐term inflammation and persistent infection, which slow healing. Wound spray is a product that be rapidly applied to large irregularly dynamic wounds, quickly form protective film situ inhibit external environmental infection. In this study, biodegradable A B combined multi‐functional hydrogel developed with methacrylate‐modified chitosan (CSMA 1st ) ferulic acid (FA) as type raw materials oxidized Bletilla striata polysaccharide (OBSP) materials. The precursor CSMA ‐FA/OBSP (CSOB‐FA formed by the self‐cross‐linking of Schiff base bonds, CSMA‐FA/OBSP (CSOB‐FA) after UV–vis light, so fits wound. Rapid spraying curing provide sufficient flexibility rapidity for wounds has good injectability, adhesive, mechanical strength. rats miniature pigs, shrink promote healing infected enrichment fibrocyte populations. Therefore, multifunctional protect irregular prevent wound infection secondary injury, used safe effective treatment, prospect development.

Язык: Английский

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