Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect DOI
Yiyang Zhao,

Wanglin Duan,

Bin Zhu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Osteoarthritis (OA) is the most common degenerative joint disease, causing pain, disability, and economic strain. Combining nanozymes with dopamine (DOPA)‐based adhesives offers a promising approach to effectively modulate microenvironment of OA‐affected tissues. However, traditional fabrication methods DOPA‐based often involve external oxidants or curing agents, which can introduce additional oxidative stress, posing systemic risks. Here, different enzyme‐catalyzed activities platinum–copper (PtCu) at pH values are utilized directly catalyze cross‐linking DOPA‐modified hyaluronic acid (HAD), representing new polymerization method for phenol‐based bioadhesives. The resulting adhesive (HAD/PtCu/platelet‐rich plasma (PRP)), when combined PRP, mitigates generation proinflammatory factors, scavenges reactive oxygen species, boosts hypoxic chemotaxis chondrocytes, stimulates chondrocyte proliferation migration, protects interleukin‐1β‐treated human articular C28/I2 cells from further OA advancement. Additionally, in vivo assessments show that HAD/PtCu/PRP significantly alleviates pain improves knee osteoarthritic rats. These findings suggest provides alternative therapy.

Language: Английский

A multifunctional membrane based on TiO2/PCN-224 heterojunction with synergistic photocatalytic-photothermal activity under visible-light irradiation DOI

Zhongxi Lu,

Jingsong Gao,

Shaosheng Rao

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2023, Volume and Issue: 342, P. 123374 - 123374

Published: Oct. 7, 2023

Language: Английский

Citations

39
Light-responsive Au@Zn-TCPP nanozyme functionalized with cell-penetrating peptide and antisense oligonucleotide for sensing living bacteria and synergistic therapy of diabetic wounds DOI
Xuan Zhang, Yijun Liu, Qiuyan Guo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 150945 - 150945

Published: April 2, 2024

Language: Английский

Citations

9
Recent advances on biomedical applications of zirconium-based Nanozymes: A review DOI
Mostafa Ghafori-Gorab,

Amir Kashtiaray,

Mahdi Karimi

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159464 - 159464

Published: Jan. 1, 2025

Language: Английский

Citations

1
Research Progress of Metal–Organic Frameworks as Drug Delivery Systems DOI

Chenxin Liu,

Chaoying Tian,

Jialing Guo

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(33), P. 43156 - 43170

Published: Aug. 12, 2024

Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in biomedical field based on advantages internal porosity, customizable facile surface modification. This review examines utilization drug delivery systems, focusing research progress from aspects coloading intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, multifunctional living carriers. In addition, current challenges faces also discussed. The aims to provide a reference for further application as advanced systems.

Language: Английский

Citations

7
A Comparative Analysis of the Antibacterial Spectrum of Ultrasmall Manganese Ferrite Nanozymes with Varied Surface Modifications DOI
Junhua Han, Yingxian Chen, Xin Xiang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(12), P. 14385 - 14404

Published: March 15, 2024

Bacterial infectious diseases pose a significant global challenge. However, conventional antibacterial agents exhibit limited therapeutic effectiveness due to the emergence of drug resistance, necessitating exploration novel strategies. Nanozymes have emerged as highly promising alternative antibiotics, owing their particular catalytic activities against pathogens. Herein, we synthesized ultrasmall-sized MnFe2O4 nanozymes with different charges (MnFe2O4–COOH, MnFe2O4–PEG, MnFe2O4–NH2) and assessed capabilities. It was found that exhibited both antibiofilm properties attributed excellent peroxidase-like small sizes, enabling them penetrate biofilms interact bacteria. Moreover, effectively expedite wound healing within 12 days facilitate tissue repair regeneration while concurrently reducing inflammation. MnFe2O4–COOH displayed favorable activity Gram-positive bacteria, 80% bacterial removal efficiency MRSA by interacting phosphatidylglycerol (PG) cardiolipin (CL) membrane. By negatively charged bacteria surfaces, MnFe2O4–NH2 demonstrated most broad-spectrum activity, 95 85% methicillin-resistant Staphylococcus aureus (MRSA) P. aeruginosa, respectively. MnFe2O4–PEG dissipated membrane potential reduced ATP levels in showing relatively activity. To conclude, offer approach for treating infections.

Language: Английский

Citations

6
Stimuli‐Responsive New Horizons for Biomedical Applications: Metal–Organic Framework‐Based Nanozymes DOI
Jingyu Yan, Yifan Zhao,

Meijun Du

et al.

Small Structures, Journal Year: 2024, Volume and Issue: 5(7)

Published: April 26, 2024

Nanozymes, nanomaterials exhibiting enzyme‐mimicking activities, have gained considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency. Among these, metal–organic framework (MOF)‐based nanozymes distinguish themselves by distinct structure customizable characteristics. Researchers explored MOF‐based as a platform for developing stimuli‐responsive behaviors. This work first presents the categorization of nanozymes, which are designed mimic catalytic functions oxidases, peroxidases, catalase, superoxide dismutase, hydrolases, multifunctional enzymes. Crafting includes customizing reactions particular stimuli, including pH, temperature, light, or biomolecular triggers, ensuring enhanced specificity potency performance amid environmental changes. Moreover, these exhibit immense potential biomedical applications, playing crucial roles therapeutic interventions like cancer therapy tissue regeneration. Finally, article delves into future opportunities challenges within emerging research frontiers. These offer novel avenues advanced strategies, providing prospects innovative applications.

Language: Английский

Citations

6
Nanomaterials: Recent Advances in Knee Osteoarthritis Treatment DOI
Yufeng Peng,

Ying Wang,

Ru Bai

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Osteoarthritis (OA) of the knee is most prevalent degenerative joint condition that places a substantial financial and medical burden on society. However, due to drawbacks such as inefficiency, adverse effects, brief duration action, clinical efficacy current major therapies for OA largely restricted. Therefore, novel medication development highly required address these issues. Numerous studies in recent years have established nanomaterials can be potential effective way overcome challenges. In this review, anatomical distinctions between healthy joints, well advances field treatment are summarized. The limits present therapeutic strategies treating also highlighted, prospects future.

Language: Английский

Citations

6
CRISPR/Cas12a trans-cleavage mediated photoelectrochemical biosensor based on zeolitic imidazolate framework-67 for ATP determination DOI
Linghui Kong,

Chengxue Zong,

Xiaodong Chen

et al.

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(7)

Published: June 18, 2024

Language: Английский

Citations

5
Regulator of oxidative balance: Research progress of nanozymes in ROS-related diseases DOI
Xiang Wang, Zidong Wang, Siyuan Hu

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102540 - 102540

Published: Jan. 22, 2025

Language: Английский

Citations

0
Metal‐Organic Frameworks for the Therapy of Inflammatory Diseases DOI Open Access
Heng Zhao, Christian Serre, Nathalie Steunou

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Inflammation is a natural immune response triggered by harmful external or internal stimuli. However, when inflammation fails to resolve and restore basal homeostasis, it can lead various inflammatory diseases such as rheumatoid arthritis (RA), bowel disease (IBD), diabetic chronic wound (DCW). The modulation of follows highly complex mechanism, monotherapy often insufficient for treating conditions. Therefore, developing next-generation nanocarriers anti-inflammatory drug delivery multi-target combination therapies critical. Metal-organic frameworks (MOFs), class porous coordination polymers with large surface areas adaptable porosity, have emerged promising systems (DDS) due their biodegradability, high loading capacity, stimuli-responsive release, ease functionalization. Over the past five years, MOFs shown significant promise in diseases, either DDS intrinsic anti-oxidative agents. Additionally, hybrid MOFs, which combine nanozymes, offer multifunctional platform great potential. This review intends provide comprehensive recent development MOF-based nanomedicines therapy diseases. challenges future directions research into use treatment these will also be discussed.

Language: Английский

Citations

0