Inflammatory Bowel Diseases,
Год журнала:
2021,
Номер
28(4), С. 639 - 648
Опубликована: Дек. 6, 2021
Abstract
Ulcerative
colitis
(UC),
an
etiologically
complicated
and
relapsing
gastrointestinal
disease,
is
characterized
by
the
damage
of
mucosal
epithelium
destruction
intestinal
homeostasis,
which
has
caused
a
huge
social
economic
burden
on
health
system
all
over
world.
Its
pathogenesis
multifactorial,
including
environmental
factors,
genetic
susceptibility,
epithelial
barrier
defect,
symbiotic
flora
imbalance,
dysregulated
immune
response.
Thus
far,
although
cells
have
become
focus
most
research,
it
increasingly
clear
that
play
important
role
in
progression
UC.
Notably,
apoptosis
vital
catabolic
process
cells,
crucial
to
maintain
stability
environment
regulate
ecology.
In
this
review,
mechanism
induced
reactive
oxygen
species
endoplasmic
reticulum
stress,
as
well
excessive
dysfunction
gut
microbiology
imbalance
are
systematically
comprehensively
summarized.
Further
understanding
UC
may
provide
novel
strategy
for
its
therapy
clinical
practices
development
new
drugs.
Biomedicines,
Год журнала:
2021,
Номер
9(2), С. 216 - 216
Опубликована: Фев. 20, 2021
A
decline
in
mitochondrial
redox
homeostasis
has
been
associated
with
the
development
of
a
wide
range
inflammatory-related
diseases.
Continue
discoveries
demonstrate
that
mitochondria
are
pivotal
elements
to
trigger
inflammation
and
stimulate
innate
immune
signaling
cascades
intensify
inflammatory
response
at
front
different
stimuli.
Here,
we
review
evidence
an
exacerbation
levels
mitochondrial-derived
reactive
oxygen
species
(ROS)
contribute
mito-inflammation,
new
concept
identifies
compartmentalization
process,
which
mitochondrion
acts
as
central
regulator,
checkpoint,
arbitrator.
In
particular,
discuss
how
ROS
specific
aspects
mito-inflammation
diseases,
such
neurodegenerative
disorders,
cancer,
pulmonary
diabetes,
cardiovascular
Taken
together,
these
observations
indicate
influence
regulate
number
key
strategies
directed
reduce
or
neutralize
might
have
broad
beneficial
effects
on
ACS Applied Bio Materials,
Год журнала:
2022,
Номер
5(9), С. 4028 - 4054
Опубликована: Авг. 31, 2022
Research
on
the
role
of
reactive
oxygen
species
(ROS)
in
aging
process
has
advanced
significantly
over
last
two
decades.
In
light
recent
findings,
ROS
takes
part
cells
along
with
contributing
to
various
physiological
signaling
pathways.
Antioxidants
being
cells'
natural
defense
mechanism
against
ROS-mediated
alteration,
play
an
imperative
maintain
intracellular
homeostasis.
Although
complete
understanding
regulated
is
yet
be
fully
comprehended,
current
insights
into
sources
cellular
and
their
correlation
age-related
diseases
are
portrayed
this
review.
addition,
results
effect
antioxidants
homeostasis
as
well
advances
clinical
trials
also
discussed
detail.
The
future
perspective
ROS-antioxidant
dynamics
antiaging
research
marshaled
provide
directions
for
fields.
Biomolecules,
Год журнала:
2022,
Номер
12(11), С. 1640 - 1640
Опубликована: Ноя. 4, 2022
Postbiotics
are
a
new
category
of
biotics
that
have
the
potential
to
confer
health
benefits
but,
unlike
probiotics,
do
not
require
living
cells
induce
effects
and
thus
subject
food
safety
requirements
apply
live
microorganisms.
defined
as
“preparation
inanimate
microorganisms
and/or
their
components
confers
benefit
on
host”.
Postbiotic
include
short-chain
fatty
acids,
exopolysaccharides,
vitamins,
teichoic
bacteriocins,
enzymes
peptides
in
non-purified
inactivated
cell
preparation.
While
research
into
postbiotics
is
its
infancy,
there
increasing
evidence
modulate
human
health.
Specifically,
number
been
shown
improve
gut
by
strengthening
barrier,
reducing
inflammation
promoting
antimicrobial
activity
against
pathogens.
Additionally,
being
conducted
application
other
areas
body,
including
skin,
vagina
oral
cavity.
The
purpose
this
review
set
out
current
postbiotics,
demonstrate
how
currently
used
commercial
products
identify
knowledge
gaps
where
further
needed
for
future
applications
postbiotics.
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 985 - 985
Опубликована: Авг. 14, 2024
Gut
dysbiosis,
resulting
from
an
imbalance
in
the
gut
microbiome,
can
induce
excessive
production
of
reactive
oxygen
species
(ROS),
leading
to
inflammation,
DNA
damage,
activation
immune
system,
and
epigenetic
alterations
critical
genes
involved
metabolic
pathways.
dysbiosis-induced
inflammation
also
disrupt
barrier
integrity
increase
intestinal
permeability,
which
allows
gut-derived
toxic
products
enter
liver
systemic
circulation,
further
triggering
oxidative
stress,
associated
with
diseases.
However,
specific
metabolites,
such
as
short-chain
fatty
acids
(SCFAs),
lactate,
vitamins,
modulate
stress
system
through
mechanisms,
thereby
improving
function.
microbiota
diet-induced
diseases,
obesity,
insulin
resistance,
dyslipidemia,
hypertension,
transfer
next
generation,
involving
mechanisms.
In
this
review,
we
will
introduce
key
that,
along
dysbiosis
ROS,
are
engaged
developing
Finally,
discuss
potential
therapeutic
interventions
dietary
modifications,
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
may
reduce
syndrome
by
altering
alterations.
summary,
review
highlights
crucial
role
pathogenesis
a
particular
focus
on
(including
histone
methylomics,
RNA
interference)
that
prevent
or
improve
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(49)
Опубликована: Июль 28, 2023
Abstract
Abnormal
activation
of
the
gut
mucosal
immune
system
and
a
highly
dysregulated
microbiota
play
essential
roles
in
progression
inflammatory
bowel
disease
(IBD).
The
clinical
treatment
IBD
remains
challenging,
with
first‐line
drugs
showing
limited
efficacy
significant
side
effects.
A
reactive
oxygen
species
(ROS)‐activated
CO
versatile
nanomedicine
(CMPs)
capable
remodeling
immune‐microbiota
microenvironment
via
potent
anti‐oxidant,
anti‐inflammatory,
antimicrobial
effects
is
developed.
CORM‐401‐loaded
mannose‐modified
peptide
dendrimer
nanogel:
CMPs
preferentially
congregate
on
surface
damaged
colon
mucosa
after
rectal
administration
are
subsequently
internalized
by
activated
cells.
CORM‐401
can
release
numerous
molecules
response
to
high
ROS
levels
cells
at
site
IBD,
resulting
multiple
therapeutic
In
vitro
vivo
studies
have
demonstrated
that
scavenge
ROS,
suppress
responses,
eliminate
pathogens,
alleviate
colitis
mouse
models.
RNA
sequencing
reveals
successfully
remodel
homeostasis
scavenging
inhibiting
NF‐κB/p38MAPK,
activating
PI3K‐Akt,
HIF‐1‐induced
glycolysis.
16S
ribosomal
shows
flora
composition
restraining
detrimental
bacteria
augmenting
beneficial
bacteria.
This
study
develops
promising
for
management
IBD.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 203 - 220
Опубликована: Март 5, 2024
Ulcerative
colitis
(UC)
is
characterized
by
chronic
inflammatory
processes
of
the
intestinal
tract
unknown
origin.
Current
treatments
lack
understanding
on
how
to
effectively
alleviate
oxidative
stress,
relieve
inflammation,
as
well
modulate
gut
microbiota
for
maintaining
homeostasis
synchronously.
In
this
study,
a
novel
drug
delivery
system
based
metal
polyphenol
network
(MPN)
was
constructed
via
coordination
between
epigallocatechin
gallate
(EGCG)
and
Fe
