Trained immunity in chronic inflammatory diseases and cancer
Nature reviews. Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Differential structure and immunomodulatory functions of lipophosphoglycan between Leishmania spp
Immunology Letters,
Год журнала:
2024,
Номер
268, С. 106885 - 106885
Опубликована: Июнь 18, 2024
Leishmaniasis
is
a
collective
term
for
several
tropical,
neglected
diseases
caused
by
protozoans
of
the
species
Leishmania,
20
which
causing
disease
in
humans
ranging
from
localised
self-healing
lesions
to
chronic
manifestations
affect
skin
or
inner
organs.
Although
millions
infections
are
accounted
annually,
treatment
options
scarce
and
limited
medication
associated
with
heavy
side-effects
increasing
antibiotic
resistance.
Case
studies
point
towards
immunotherapy
as
effective
alternative
relying
on
immunomodulatory
properties
e.g.,
Bacillus
Calmette-Guérin
vaccine.
Leishmania
parasites
also
known
modulate
immune
system,
yet
underlying
macromolecules
surface
molecules
remain
widely
under
characterised.
With
this
short
review,
we
aim
provide
complete
summary
existing
literature
describing
one
most
expressed
molecule
spp,
lipophosphoglycan
(LPG),
shows
great
variability
between
different
lifecycle
stages
spp.
Complete
characterisation
LPG
may
aid
improve
development
vaccination
strategies,
open
new
avenues
exploit
unrelated
conditions.
Язык: Английский
M28 family peptidase derived from Peribacillus frigoritolerans initiates trained immunity to prevent MRSA via the complosome-phosphatidylcholine axis
Gut Microbes,
Год журнала:
2025,
Номер
17(1)
Опубликована: Март 30, 2025
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
represents
a
major
global
health
threat
due
to
its
resistance
conventional
antibiotics.
The
commensal
microbiota
maintains
symbiotic
relationship
with
the
host,
playing
essential
roles
in
metabolism,
energy
regulation,
immune
modulation,
and
pathogen
control.
Mammals
harbor
wide
range
of
bacteria
capable
producing
unique
metabolites
potential
therapeutic
properties.
This
study
demonstrated
that
M28
family
peptidase
(M28),
derived
from
Peribacillus
frigoritolerans
(P.
f),
provided
protective
effects
against
MRSA-induced
pneumonia.
enhanced
phagocytosis
bactericidal
activity
macrophages
by
inducing
trained
immunity.
RNA
sequencing
metabolomic
analyses
identified
CFB-C3a-C3aR-HIF-1α
axis-mediated
phosphatidylcholine
accumulation
as
key
mechanism
for
M28-induced
Phosphatidylcholine,
like
M28,
also
induced
To
enhance
M28-mediated
potential,
it
was
encapsulated
liposomes
(M28-LNPs),
which
exhibited
superior
immune-stimulating
properties
compared
alone.
In
vivo
experiments
revealed
M28-LNPs
significantly
reduced
bacterial
loads
lung
damage
following
MRSA
infection,
protection
Klebsiella
pneumoniae
Candida
albicans.
We
first
confirmed
link
between
complement
activation
immunity,
offering
valuable
insights
into
treatment
prevention
complement-related
autoimmune
diseases.
Язык: Английский
Salmonella LVR01 triggers antagonistic two-armed innate immune memory that impacts on antitumor efficacy
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 30, 2025
The
current
understanding
of
innate
immune
memory
encompasses
both
trained
immunity
and
tolerance,
where
cells
can
exhibit
enhanced
responsiveness
or
paralysis
upon
subsequent
stimuli,
respectively.
Various
agents
induce
either
these
responses,
including
β-glucan,
Leishmania,
BCG
LPS.
is
a
clinically
approved
immunotherapy
for
bladder
cancer
BCG-induced
important
in
driving
anti-tumor
adaptive
immunity.
Salmonella
also
shows
promise
treatment,
eliciting
potent
but
with
transitory
effects.
This
led
us
to
investigate
whether
LVR01,
like
BCG,
triggers
its
impact
on
responses.
Herein,
we
report
that
induces
an
response
bone
marrow
cells,
characterized
by
robust
cytokine
second
stimulus,
fashion
resembles
Coherently
that,
administration
tumor
implanted
later
time,
resulting
slow
growth
extended
survival.
However,
vitro
stimulation
human
monocytes
murine
bone-marrow
derived
myeloid-enriched
results
decreased
production
cytokines
resembling
paralysis.
Overall,
our
suggest
LVR01
responses
memory,
as
well
monocytes.
These
two
antagonistic
effects
could
be
the
basis
effect
treatment
further
investigation
phenomena
shed
light
how
improve
Salmonella-based
immunotherapies
cancer.
Язык: Английский
Trained immunity-based Adjuvated vaccines (TIbAV) approach: β-glucans as example
Vaccine,
Год журнала:
2025,
Номер
57, С. 127240 - 127240
Опубликована: Май 1, 2025
Язык: Английский
Structural characteristics and anti-tumor activity of alcohol-precipitated polysaccharides from Cordyceps militaris under different ethanol concentrations
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
278, С. 134784 - 134784
Опубликована: Авг. 14, 2024
Язык: Английский
Therapeutic potential of trained immunity for malignant disease
Immunological Medicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 12
Опубликована: Дек. 5, 2024
Trained
immunity
(TI)
is
functional
memory
displayed
by
innate
immune
cells
(IICs).
TI
facilitates
rapid,
non-specific
responses
to
pathogens
upon
secondary
challenge.
It
driven
immunological
signaling
and
metabolic
rewriting
via
epigenetic
alteration,
triggered
recognition
of
certain
stimuli.
Recently,
checkpoint
inhibitors
have
come
into
common
use
in
clinical
oncology
settings,
genetically
engineered
cytotoxic
T
comprise
a
potent
cancer
treatment
strategy.
However,
the
contributions
tumor
microenvironment
(TME)
are
only
beginning
be
uncovered.
Accumulating
evidence
that
various
microorganisms
vaccines
convey
tumoricidal
ability
suggest
may
become
useful
anti-cancer
tool.
The
expected
roles
therapy
1)
promotion
proinflammatory
cytokine
section,
2)
enhancement
phagocytosis,
3)
quick
expansion
recruitment
cancer-specific
TME
through
neoantigen
presentation,
4)
reversal
immunosuppression
TME,
5)
removal
associated
with
carcinogenesis
or
development.
Medium-
long-term
durability
reduce
risk
Recent
findings
on
usher
new
aspirations
for
treatment.
Язык: Английский
Determination of key hub genes in Leishmaniasis as potential factors in diagnosis and treatment based on a bioinformatics study
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Protocol to culture Leishmania protozoans for lipophosphoglycan extraction and purification
STAR Protocols,
Год журнала:
2024,
Номер
5(4), С. 103468 - 103468
Опубликована: Дек. 1, 2024
Lipophosphoglycan
(LPG)
is
a
macromolecule
on
the
surface
of
Leishmania
spp.
parasites.
The
biochemical
structure
LPG
varies
throughout
parasites'
life
cycle
between
proliferative
(procyclic)
and
infective
(metacyclic)
stages,
as
well
species
strains.
Here,
we
outline
protocol
for
growing
parasites
in
vitro
to
harvest
LPG.
We
describe
steps
parasite
differentiation
extraction
purification.
has
applications
medical
research,
such
trained
immunity
immunotherapy
cancer.
For
complete
details
use
execution
this
protocol,
please
refer
dos
Santos
et
al.1.
Язык: Английский