International Journal of Biological Macromolecules, Год журнала: 2023, Номер 249, С. 126057 - 126057
Опубликована: Июль 29, 2023
Язык: Английский
Frontiers in Chemistry, Год журнала: 2023, Номер 10
Опубликована: Янв. 4, 2023
Chemotherapy is the mainstay of cancer treatment today. Chemotherapeutic drugs are non-selective and can harm both healthy cells, causing a variety adverse effects such as lack specificity, cytotoxicity, short half-life, poor solubility, multidrug resistance, acquiring stem-like characteristics. There paradigm shift in drug delivery systems (DDS) with advent smarter ways targeted treatment. Smart Drug Delivery Systems (SDDSs) stimuli responsive be modified chemical structure response to light, pH, redox, magnetic fields, enzyme degradation future translational medicine. Therefore, SDDSs have potential used viable alternative traditional chemotherapy. This review focuses mostly on delivery, inorganic nanocarriers (Carbon nanotubes, gold nanoparticles, Meso-porous silica quantum dots etc. ), organic (Dendrimers, liposomes, micelles), antibody-drug conjugates (ADC) small molecule (SMDC) based for therapy strategies cells.
Язык: Английский
Процитировано
32
Advanced Science, Год журнала: 2023, Номер 10(25)
Опубликована: Июнь 21, 2023
Abstract Advanced functional two‐dimensional (2D) nanomaterials offer unique advantages in drug delivery systems for disease treatment. Kaolinite (Kaol), a nanoclay mineral, is natural 2D nanomaterial because of its layered silicate structure with nanoscale layer spacing. Recently, Kaol used as carrier controlled release and improved dissolution owing to advantageous properties such surface charge, strong biocompatibility, naturally structure, making it an essential development direction nanoclay‐based carriers. This review outlines the main physicochemical characteristics modification methods application biomedicine. The safety biocompatibility are addressed, details antibacterial, anti‐inflammatory, anticancer treatment discussed. Furthermore, challenges prospects Kaol‐based biomedicine recommends directions further nanocarriers by improving their expanding bioapplication range Kaol.
Язык: Английский
Процитировано
31
Small, Год журнала: 2023, Номер 19(37)
Опубликована: Май 24, 2023
Invasive glioma usually disrupts the integrity of blood-brain barrier (BBB), making delivery nanodrugs across BBB possible, but sufficient targeting ability is still avidly needed to improve drug accumulation in glioma. Membrane-bound heat shock protein 70 (Hsp70) expressed on membrane cells rather than adjacent normal cells, therefore it can serve as a specific target. Meanwhile, prolonging retention tumors important for active-targeting nanoparticles overcome receptor-binding barriers. Herein, Hsp70-targeting and acid-triggered self-assembled gold (D-A-DA/TPP) are proposed realize selective doxorubicin (DOX) In weakly acidic matrix, D-A-DA/TPP formed aggregates prolong retention, efficiency facilitate acid-responsive DOX release. induced immunogenic cell death (ICD) promote antigen presentation. combination with PD-1 checkpoint blockade further activate T provokes robust anti-tumor immunity. The results showed that induce more apoptosis. Furthermore, vivo studies indicated plus significantly improved median survival time. This study offeres potential nanocarrier combining size-tunable strategy active increase enrichment synergizes achieve chemo-immunotherapy.
Язык: Английский
Процитировано
28
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 84, С. 104562 - 104562
Опубликована: Май 13, 2023
Язык: Английский
Процитировано
26
Biomaterials Research, Год журнала: 2023, Номер 27(1)
Опубликована: Фев. 9, 2023
Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.
Язык: Английский
Процитировано
25
Materials Science and Engineering B, Год журнала: 2023, Номер 297, С. 116816 - 116816
Опубликована: Авг. 19, 2023
Язык: Английский
Процитировано
23
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Язык: Английский
Процитировано
14
International Journal of Pharmaceutics, Год журнала: 2024, Номер 651, С. 123763 - 123763
Опубликована: Янв. 2, 2024
Nanomaterials' application in cancer therapy has been driven by their ability to encapsulate chemotherapeutic drugs as well reach the tumor site. Nevertheless, nanomedicines' translation limited due lack of specificity towards cells. Although nanomaterials' surface can be coated with targeting ligands, such mostly achieved through non-covalent functionalization strategies that are prone premature detachment. Notwithstanding, cells often establish resistance mechanisms impair effect loaded drugs. This bottleneck may addressed using near-infrared (NIR)-light responsive nanomaterials. The NIR-light triggered hyperthermic generated these nanomaterials cause irreversible damage or sensitize them chemotherapeutics' action. Herein, a novel covalently functionalized targeted NIR-absorbing nanomaterial for chemo-photothermal was developed. For such, dopamine-reduced graphene oxide were bonded hyaluronic acid, and then doxorubicin (DOX/HA-DOPA-rGO). produced showed suitable physicochemical properties, high encapsulation efficiency, photothermal capacity. vitro studies revealed cytocompatible display an improved uptake CD44-overexpressing breast Importantly, combination DOX/HA-DOPA-rGO NIR light reduced cells' viability just 23 %, showcasing potential therapy.
Язык: Английский
Процитировано
9
Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)
Опубликована: Янв. 5, 2024
Abstract Background Medical fraternity are continuously pitching toward the development of novel mechanisms to combat menace cancer and enhance efficacy prevailing molecules. During drug phase, majority new molecular entity pose a threat due hydrophobic nature, that compromises its bioavailability upon administration. These suboptimal accumulation low loading hampers clinical translation in therapy. Main body abstract Nanotechnology with valuable advantages create possibilities accelerate treatment. Compared matrix-based formulations, nanocrystals (NCs) smaller size, high loading, active targeting, extended circulation, great structural stability, tailored dissolution, being carrier free have sparked lot interest delivery. Many drugs were explored as NCs such as—doxorubicin, paclitaxel, campothecin so on. However, premature leakage clearance by mononuclear phagocytosis system lead some obstacles applications NCs. Conclusion In recent years, strategies leading surface modification applied improve uncontrolled release targeting efficiency tumor cells. The current review sheds light on various properties nanocrystals, brief insights fabricating techniques, approaches for NCs, their imaging therapeutics.
Язык: Английский
Процитировано
9
Nanoscale, Год журнала: 2024, Номер 16(8), С. 4063 - 4081
Опубликована: Янв. 1, 2024
Based on atomistic molecular dynamics simulations and machine learning approaches we unveil the binding mechanism of a cyclic-RGD-ligand activated NP (PEGylated-TiO 2 ) to its receptor protein (integrin-α V β 3 overexpressed in many tumor cells.
Язык: Английский
Процитировано
9