International Journal of Pharmaceutics X,
Год журнала:
2023,
Номер
6, С. 100214 - 100214
Опубликована: Окт. 29, 2023
Combination
therapy
represents
a
promising
strategy
in
cancer
management
by
reducing
chemotherapy
resistance
and
associated
side
effects.
Silymarin
(SLM)
has
been
extensively
investigated
due
to
its
potent
antioxidant
properties
demonstrated
efficacy
against
cells.
Under
certain
conditions
however,
polyphenolic
compounds
may
also
exhibit
prooxidant
activity
elevating
intracellular
reactive
oxygen
species
(ROS),
which
can
harm
the
target
In
this
study,
we
hypothesized
that
simultaneous
administration
of
iron
(Fe)
could
alter
characteristic
SLM
nanoliposomes
(SLM
Lip)
state.
Hence,
first
developed
Lip
preparation
using
lipid
film
method,
then
anti-oxidant
as
well
cytotoxicity
liposomal
preparation.
We
explored
concomitant
sucrose
SML
on
tumor
growth
survival
mice
bearing
tumors.
observed
exposing
cells
iron,
consecutive
treatment
with
(Fe
+
induce
greater
toxicity
4
T1
breast
compared
Lip.
Further,
Fe
combination
time-dependent
effect
catalase
Lip,
while
did
not
cell
activity.
mouse
model,
therapeutic
was
superior
treated
animals
survived
longer.
The
histopathological
findings
reveal
significant
damage
major
organs,
whereas
most
necrosis
evident
treatment.
outcomes
present
investigation
unequivocally
underscored
prospective
use
context
therapy,
warrants
further
scrutiny.
RGD
peptide
can
be
found
in
cell
adhesion
and
signaling
proteins,
such
as
fibronectin,
vitronectin,
fibrinogen.
peptides'
principal
function
is
to
facilitate
by
interacting
with
integrin
receptors
on
the
surface.
They
have
been
intensively
researched
for
use
biotechnology
medicine,
including
incorporation
into
biomaterials,
conjugation
medicinal
molecules
or
nanoparticles,
labeling
imaging
agents.
peptides
utilized
specifically
target
cancer
cells
tumor
vasculature
engaging
these
integrins,
improving
drug
delivery
efficiency
minimizing
adverse
effects
healthy
tissues.
RGD-functionalized
carriers
are
a
viable
option
therapy
this
focused
approach
has
demonstrated
promise
future.
Writing
review
significantly
influence
how
drugs
developed
future
our
understanding
of
peptide,
finding
knowledge
gaps,
fostering
innovation,
making
design
easier.
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 6, 2024
Abstract
The
quest
for
effective
and
reliable
methods
of
delivering
medications,
with
the
aim
improving
delivery
therapeutic
agent
to
intended
location,
has
presented
a
demanding
yet
captivating
field
in
biomedical
research.
concept
smart
drug
systems
is
an
evolving
approach,
serving
as
model
directing
drugs
specific
targets
or
sites.
These
have
been
developed
specifically
target
regulate
administration
substances
diverse
array
chronic
conditions,
including
periodontitis,
diabetes,
cardiac
diseases,
inflammatory
bowel
rheumatoid
arthritis,
different
cancers.
Nevertheless,
numerous
comprehensive
clinical
trials
are
still
required
ascertain
both
immediate
enduring
impacts
such
nanosystems
on
human
subjects.
This
review
delves
into
benefits
vehicles,
aiming
enhance
comprehension
their
applicability
addressing
present
medical
requirements.
Additionally,
it
touches
upon
current
applications
these
stimuli‐reactive
biomedicine
outlines
future
development
prospects.
Journal of Controlled Release,
Год журнала:
2024,
Номер
368, С. 703 - 727
Опубликована: Март 19, 2024
Drug
delivery
platforms
have
gracefully
emerged
as
an
indispensable
component
of
novel
cancer
chemotherapy,
bestowing
targeted
drug
distribution,
elevating
therapeutic
effects,
and
reducing
the
burden
unwanted
side
effects.
In
this
context,
hybrid
systems
artfully
harnessing
virtues
liposomes
hydrogels
bring
remarkable
benefits,
especially
for
localized
therapy,
including
intensified
stability,
excellent
amenability
to
hydrophobic
hydrophilic
medications,
controlled
liberation
behavior,
appropriate
mucoadhesion
mucopenetration
shift.
Moreover,
three-dimensional
biocompatible
liposome-integrated
hydrogel
networks
attracted
unprecedented
interest
in
tissue
regeneration,
given
their
tunable
architecture
physicochemical
properties,
well
enhanced
mechanical
support.
This
review
elucidates
presents
cutting-edge
developments
recruiting
treatment
regeneration.
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 11, 2024
Nanoparticulate
delivery
systems
have
been
attracting
attention
in
pharmaceutical
sciences
for
enhanced
drug
bioavailability
and
targeted
delivery.
Specifically,
these
can
enhance
the
solubility
of
poorly
water-soluble
drugs,
protect
therapeutic
agents
from
degradation,
prolong
circulation
time
body,
control
release,
facilitate
precise
targeting
drugs
to
specific
tissues
or
cells.
However,
once
administered
into
nanoparticles
often
encounter
significant
challenges
that
affect
their
efficacy
safety,
such
as
issues
with
stability,
biocompatibility,
targeting.
The
surface
properties
are
one
most
important
features
they
greatly
influence
interactions
between
themselves
biological
targets.
Key
characteristics,
charge,
hydrophobicity,
presence
functional
groups,
determine
how
behave
environments,
thereby
influencing
cellular
uptake,
ability
avoid
immune
clearance.
Modification
nanoparticle
has
shown
be
an
effective
approach
modulate
physicochemical
nanoparticles,
achieving
desired
vivo
.
This
review
aims
summarize
recent
advances
decoration
emphasis
on
improved
colloidal
reduced
toxicity,
future
perspectives
modification
approaches
also
discussed.
Therapeutic Delivery,
Год журнала:
2023,
Номер
14(5), С. 357 - 381
Опубликована: Май 1, 2023
Breast
cancer
(BC)
is
among
the
most
frequent
malignancies
women
face
around
globe.
Nanotherapeutics
are
constantly
evolving
to
overcome
limitations
of
conventional
diagnostic
and
therapeutic
approaches.
Nanotechnology-based
nanocarriers
have
a
higher
entrapment
efficiency,
low
cytotoxicity,
greater
stability
improved
half-life
than
therapy.
Nano-drug
delivery
systems
pharmacokinetics
pharmacodynamics
parameters
because
nanomeric
size.
Currently,
various
nano-formulations
in
preclinical
clinical
settings
for
breast
cancer,
like
polymeric
nanoparticles,
micelles,
nanobodies,
magnetic
liposomes,
niosomes,
gold-nanoparticles,
dendrimers
carbon-nanotubes.
This
review
highlights
recent
advancement
developing
nano-drug
BC
treatment.
will
open
gateway
researchers
understand
current
approaches
nano-formulation
improving
problems
associated
with
