Current Pharmaceutical Design,
Год журнала:
2023,
Номер
29(9), С. 640 - 651
Опубликована: Фев. 15, 2023
The
self-assembly
of
peptides
is
very
popular
in
biomedical
fields.
Peptide-based
assemblies
have
been
used
as
an
ideal
candidate
for
drug/gene
delivery,
tissue
engineering,
and
antibacterial/anticancer
agents.
morphology
structure
peptide
can
be
changed
by
altering
the
molecular
conditions.
Engineering
present
great
potential
medical
In
this
review,
function
described.
Also,
advances
peptide-
based
highlighted
applications,
such
drug
packaging
antibacterial
agents,
siRNA-targeted
delivery
vaccines.
Moreover,
challenges
future
perspectives
polypeptides
are
discussed.
Abstract
Nanoparticles
can
encapsulate
a
range
of
therapeutics,
from
small
molecule
drugs
to
sensitive
biologics,
significantly
improve
their
biodistribution
and
biostability.
Whilst
the
regulatory
approval
several
these
nanoformulations
has
proven
translatability,
there
remain
hurdles
translation
future
nanoformulations,
leading
high
rate
candidate
failing
during
drug
development
process.
One
barrier
is
that
difficulty
in
tightly
controlling
nanoscale
particle
synthesis
leads
particle-to-particle
heterogeneity,
which
hinders
manufacturing
quality
control,
checks.
To
understand
mitigate
this
heterogeneity
requires
advancements
nanoformulation
characterisation
beyond
traditional
bulk
methods
more
precise,
single
techniques.
In
review,
we
compare
commercially
available
techniques,
with
particular
focus
on
Raman
spectroscopy,
provide
guide
adoption
into
workflows,
ultimately
reduce
barriers
nanoformulations.
Graphical
Macromolecular Bioscience,
Год журнала:
2023,
Номер
24(4)
Опубликована: Дек. 27, 2023
RNA
interference
(RNAi)
technology
has
been
a
promising
treatment
strategy
for
combating
intractable
diseases.
However,
the
applications
of
RNAi
in
clinical
are
hampered
by
extracellular
and
intracellular
barriers.
To
overcome
these
barriers,
various
siRNA
delivery
systems
have
developed
past
two
decades.
The
first
approved
therapeutic,
Patisiran
(ONPATTRO)
using
lipids
as
carrier,
amyloidosis
is
one
most
important
milestones.
This
greatly
encouraged
researchers
to
work
on
creating
new
functional
carriers.
In
this
review,
recent
advances
carriers
consisting
lipids,
polymers,
polymer-modified
inorganic
particles
cancer
therapy
summarized.
Representative
examples
presented
show
structural
design
order
hurdles
associated
with
therapies.
Finally,
existing
challenges
future
perspective
developing
modality
will
be
discussed
proposed.
It
believed
that
addressed
contributions
review
promote
development
applications.
Macromolecular Bioscience,
Год журнала:
2023,
Номер
23(9)
Опубликована: Май 22, 2023
Abstract
The
efficacious
delivery
of
therapeutic
nucleic
acids
to
cancer
still
remains
an
open
issue.
Through
the
years,
several
strategies
are
developed
for
encapsulation
genetic
molecules
exploiting
different
materials,
such
as
viral
vectors,
lipid
nanoparticles
(LNPs),
and
polymeric
(NPs).
Indeed,
rapid
approval
by
regulatory
authorities
wide
use
LNPs
complexing
mRNA
coding
spark
protein
COVID‐19
vaccination
paved
way
initiation
clinical
trials
therapy.
Nevertheless,
polymers
represent
a
valuable
alternative
lipid‐based
formulations,
due
low
cost
chemical
flexibility
that
allows
conjugation
targeting
ligands.
This
review
will
analyze
status
ongoing
therapy,
including
immunotherapy
approaches,
materials.
Among
those
nanosized
carriers,
sugar‐based
backbones
interesting
category.
A
cyclodextrin‐based
carrier
(CALAA‐01)
is
first
material
enter
trial
complexed
with
siRNA
chitosan
one
most
characterized
non‐viral
vectors
able
complex
material.
Finally,
recent
advances
in
(oligo‐
polysaccharides)
complexation
advanced
preclinical
stage
be
discussed.
