Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice

Nature, Год журнала: 2023, Номер 621(7977), С. 196 - 205

Опубликована: Авг. 23, 2023

Язык: Английский

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Distinct longevity mechanisms across and within species and their association with aging

Cell, Год журнала: 2023, Номер 186(13), С. 2929 - 2949.e20

Опубликована: Июнь 1, 2023

Язык: Английский

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The Information Theory of Aging

Nature Aging, Год журнала: 2023, Номер 3(12), С. 1486 - 1499

Опубликована: Дек. 15, 2023

Язык: Английский

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Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands

Cell stem cell, Год журнала: 2023, Номер 30(11), С. 1403 - 1420

Опубликована: Окт. 20, 2023

Язык: Английский

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Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector

Experimental Gerontology, Год журнала: 2023, Номер 174, С. 112134 - 112134

Опубликована: Фев. 27, 2023

Mitochondria play a wide diversity of roles in cell physiology and have key functional implication bioenergetics biology free radicals. As the main cellular source oxygen radicals, mitochondria been postulated as mediators decline associated with biological aging. Recent evidences shown that mitochondrial radical production is highly regulated mechanism contributing to determination longevity which species-specific. This generation rate induces adaptive responses derived molecular damage components, highlighting DNA damage, consequences influence aging given animal species. In this review, we explore idea fundamental role longevity. Once basic mechanisms are discerned, approaches counter may be designed developed prevent or reverse decline, modify

Язык: Английский

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The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

Cell Metabolism, Год журнала: 2024, Номер 36(8), С. 1858 - 1881.e23

Опубликована: Июль 2, 2024

A mechanistic connection between aging and development is largely unexplored. Through profiling age-related chromatin transcriptional changes across 22 murine cell types, analyzed alongside previous mouse human organismal maturation datasets, we uncovered a transcription factor binding site (TFBS) signature common to both processes. Early-life candidate cis-regulatory elements (cCREs), progressively losing accessibility during aging, are enriched for cell-type identity TFBSs. Conversely, cCREs gaining throughout life have lower abundance of TFBSs but elevated activator protein 1 (AP-1) levels. We implicate TF redistribution toward these AP-1 TFBS-rich cCREs, in synergy with mild downregulation TFs, as driving early-life cCRE loss altering developmental metabolic gene expression. Such remodeling can be triggered by elevating or depleting repressive H3K27me3. propose that AP-1-linked opening drives disrupting thereby reprogramming transcriptome function, mechanism hijacked through ongoing opening.

Язык: Английский

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Circle(s) of Life: The Circadian Clock from Birth to Death

Biology, Год журнала: 2023, Номер 12(3), С. 383 - 383

Опубликована: Фев. 28, 2023

Most lifeforms on earth use endogenous, so-called circadian clocks to adapt 24-h cycles in environmental demands driven by the planet’s rotation around its axis. Interactions with environment change over course of a lifetime, and so does regulation clock system. In this review, we summarize how develop humans experimental rodents during embryonic development, they mature after birth what changes occur puberty, adolescence increasing age. Special emphasis is laid reproductive systems as major organizers life segments span. We discuss differences sexes outline potential areas for future research. Finally, options medical applications lifespan chronobiology are discussed.

Язык: Английский

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Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in >88,000 individuals

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(43)

Опубликована: Окт. 15, 2024

Light enhances or disrupts circadian rhythms, depending on the timing of exposure. Circadian disruption contributes to poor health outcomes that increase mortality risk. Whether personal light exposure predicts risk has not been established. We therefore investigated whether day and night light, patterns disrupt predicted UK Biobank participants (N = 88,905, 62.4 ± 7.8 y, 57% female) wore sensors for 1 wk. Day exposures were defined by factor analysis 24-h profiles. A computational model human pacemaker was applied amplitude phase from data. Cause-specific recorded in 3,750 across a mean (±SD) follow-up period 8.0 1.0 y. Individuals with brighter had incrementally lower all-cause (adjusted-HR ranges: 0.84 0.90 [50 70th percentiles], 0.74 [70 90th], 0.66 0.83 [90 100th]), those higher (aHR 1.15 1.18 1.21 1.34 compared individuals darker environments (0 50th percentiles). range: 0.96 per SD), earlier 1.16 1.30), later 1.13 1.20) risks. cardiometabolic mortality, larger hazard ratios than other causes. Findings robust adjustment age, sex, ethnicity, photoperiod, sociodemographic lifestyle factors. Minimizing maximizing keeping regular light–dark enhance rhythms may promote longevity.

Язык: Английский

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DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Май 8, 2023

Abstract At over 200 years, the maximum lifespan of bowhead whale exceeds that all other mammals. The is also second-largest animal on Earth, reaching 80,000 kg 1 . Despite its very large number cells and long lifespan, not highly cancer-prone, an incongruity termed Peto’s Paradox 2 This phenomenon has been explained by evolution additional tumor suppressor genes in larger animals, supported research elephants demonstrating expansion p53 gene 3–5 Here we show fibroblasts undergo oncogenic transformation after disruption fewer suppressors than required for human fibroblasts. However, analysis DNA repair revealed double strand breaks (DSBs) mismatches with uniquely high efficiency accuracy compared to protein CIRBP, implicated protection from genotoxic stress, was present abundance relative We CIRBP downstream RPA2, at levels cells, increase fidelity cells. These results indicate rather possessing as barriers oncogenesis, relies more accurate efficient preserve genome integrity. strategy which does eliminate damaged but repairs them may be critical cancer-free whale.

Язык: Английский

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The ticking of aging clocks

Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 35(1), С. 11 - 22

Опубликована: Окт. 23, 2023

Язык: Английский

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