International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2071 - 2071
Опубликована: Фев. 8, 2024
Nanoencapsulation
has
become
a
recent
advancement
in
drug
delivery,
enhancing
stability,
bioavailability,
and
enabling
controlled,
targeted
substance
delivery
to
specific
cells
or
tissues.
However,
traditional
nanoparticle
faces
challenges
such
as
short
circulation
time
immune
recognition.
To
tackle
these
issues,
cell
membrane-coated
nanoparticles
have
been
suggested
practical
alternative.
The
production
process
involves
three
main
stages:
lysis
membrane
fragmentation,
isolation,
coating.
Cell
membranes
are
typically
fragmented
using
hypotonic
with
homogenization
sonication.
Subsequent
fragments
isolated
through
multiple
centrifugation
steps.
Coating
can
be
achieved
extrusion,
sonication,
combination
of
both
methods.
Notably,
this
analysis
reveals
the
absence
universally
applicable
method
for
coating,
stages
differ
significantly
their
procedures.
This
review
explores
current
developments
approaches
nanoparticles,
highlighting
potential
an
effective
alternative
various
therapeutic
applications.
Materials Horizons,
Год журнала:
2023,
Номер
10(9), С. 3507 - 3522
Опубликована: Янв. 1, 2023
Cartilage
defects
are
usually
caused
by
acute
trauma
and
chronic
degeneration.
However,
it
is
still
a
great
challenge
to
improve
the
repair
of
articular
cartilage
due
limited
self-regeneration
capacity
such
defects.
Herein,
novel
ROS-responsive
in
situ
nanocomposite
hydrogel
loaded
with
kartogenin
(KGN)
bone
marrow-derived
stem
cells
(BMSCs)
was
designed
constructed
via
enzymatic
reaction
fibrinogen
thrombin.
Meanwhile,
thioketal
(TK)-based
liposome
synthesized
load
chondrogenesis-inducing
factor
KGN,
bioenzyme
thrombin
an
ultrasound-sensitive
agent
PpIX.
Under
ultrasound
stimulation,
TK-based
destroyed,
followed
gelation
Moreover,
sustained
release
KGN
realized
regulating
conditions.
Importantly,
ROS
generation
within
microenvironment
fibrin
significantly
promoted
chondrogenic
differentiation
BMSCs
Smad5/mTOR
signalling
pathway
effectively
improved
regeneration
rat
defect
model.
Overall,
ROS-controlled
drug
has
potential
for
efficient
repair.
Theranostics,
Год журнала:
2022,
Номер
12(15), С. 6576 - 6594
Опубликована: Янв. 1, 2022
Bone
and
soft
tissue
tumors
are
complex
mesenchymal
neoplasms
that
seriously
endanger
human
health.
Over
the
past
decade,
relationship
between
microorganisms
health
diseases
is
getting
more
attention.
The
extracellular
vesicles
derived
from
bacteria
have
been
shown
to
regulate
bacterial-host
cell
communication
by
transferring
their
contents,
including
nucleic
acids,
proteins,
metabolites,
lipopolysaccharides,
peptidoglycans.
Bacteria
(BEVs)
promising
lipid-bilayer
nanocarriers
for
treatment
of
many
due
low
toxicity,
drug
loading
capacity,
ease
modification
industrialization.
Specially,
BEVs-based
cancer
therapy
has
attracted
much
attention
because
ability
effectively
stimulate
immune
responses.
In
this
review,
we
provide
an
overview
biogenesis,
composition,
isolation,
classification,
internalization
BEVs.
We
then
comprehensively
summarize
sources
BEVs
in
BEVs-related
strategies.
further
highlight
great
potential
bone
tumors.
Finally,
conclude
major
advantages
challenges
therapy.
believe
comprehensive
understanding
field
will
generate
innovative
solutions
achieve
clinical
applications.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 31, 2022
Targeted
delivery
by
either
systemic
or
local
targeting
of
therapeutics
to
the
bone
is
an
attractive
treatment
for
various
metabolism
diseases
such
as
osteoporosis,
osteoarthritis,
osteosarcoma,
osteomyelitis,
etc.
To
overcome
limitations
direct
drug
delivery,
combination
bone-targeted
agents
with
nanotechnology
has
opportunity
provide
a
more
effective
therapeutic
approach,
where
engineered
nanoparticles
cause
accumulate
in
bone,
thereby
improving
efficacy
and
minimizing
side
effects.
Here,
we
summarize
current
advances
bone-targeting
approaches
nanosystem
applications
diseases,
which
may
new
insights
into
nanocarrier-delivered
drugs
targeted
diseases.
We
envision
that
novel
carriers
developed
based
on
will
be
potential
vehicle
currently
incurable
are
expected
translated
clinical
applications.
Bioengineering,
Год журнала:
2022,
Номер
9(12), С. 728 - 728
Опубликована: Ноя. 24, 2022
Bone
tissue
engineering
(BTE)
is
a
promising
alternative
to
repair
bone
defects
using
biomaterial
scaffolds,
cells,
and
growth
factors
attain
satisfactory
outcomes.
This
review
targets
the
fabrication
of
such
as
conventional
electrohydrodynamic
techniques,
for
treatment
an
autograft,
allograft,
xenograft
sources.
Additionally,
modern
approaches
fabricating
constructs
by
additive
manufacturing,
injection
molding,
microsphere-based
sintering,
4D
printing
providing
favorable
environment
regeneration,
function,
viability,
are
thoroughly
discussed.
The
polymers
used,
methods,
advantages,
limitations
in
application
also
emphasized.
provides
future
outlook
regarding
potential
BTE
well
its
possibilities
clinical
trials.
Bioactive Materials,
Год журнала:
2022,
Номер
20, С. 166 - 178
Опубликована: Май 27, 2022
Skeletal
muscle
disorders
have
posed
great
threats
to
health.
Selective
delivery
of
drugs
and
oligonucleotides
skeletal
is
challenging.
Aptamers
can
improve
targeting
efficacy.
In
this
study,
for
the
first
time,
human
muscle-specific
ssDNA
aptamers
(HSM01,
etc.)
were
selected
identified
with
Systematic
Evolution
Ligands
by
Exponential
Enrichment
(SELEX).
The
HSM01
aptamer
preferentially
interacted
cells
Theranostics,
Год журнала:
2022,
Номер
13(1), С. 20 - 39
Опубликована: Ноя. 29, 2022
Currently,
biological
membrane-derived
nanoparticles
(NPs)
have
shown
enormous
potential
as
drug
delivery
vehicles
due
to
their
outstanding
biomimetic
properties.To
make
these
NPs
more
adaptive
complex
systems,
some
methods
been
developed
modify
biomembranes
and
endow
them
with
functions
while
preserving
inherent
natures.In
this
review,
we
introduce
five
common
approaches
used
for
biomembrane
decoration:
membrane
hybridization,
the
postinsertion
method,
chemical
methods,
metabolism
engineering
gene
engineering.These
can
functionalize
a
series
of
derived
from
red
blood
cells,
white
tumor
platelets,
exosomes
so
on.Biomembrane
could
markedly
facilitate
targeted
delivery,
treatment
diagnosis
cancer,
inflammation,
immunological
diseases,
bone
diseases
Alzheimer's
disease.It
is
anticipated
that
modification
techniques
will
advance
biomembrane-derived
into
broader
applications
in
future.
Pharmaceutics,
Год журнала:
2022,
Номер
14(5), С. 1069 - 1069
Опубликована: Май 17, 2022
Titanium
and
its
alloys
are
the
most
widely
applied
orthopedic
dental
implant
materials
due
to
their
high
biocompatibility,
superior
corrosion
resistance,
outstanding
mechanical
properties.
However,
lack
of
osseointegration
remains
main
obstacle
successful
implantation.
Previous
traditional
surface
modification
methods
titanium-based
implants
cannot
fully
meet
clinical
needs
osseointegration.
The
construction
local
drug
delivery
systems
(e.g.,
antimicrobial
systems,
anti-bone
resorption
etc.)
on
has
been
proved
be
an
effective
strategy
improve
Meanwhile,
these
can
also
combined
with
methods,
such
as
anodic
oxidation,
acid
etching,
coating
technology,
etc.,
achieve
desirable
enhanced
In
this
paper,
we
review
research
progress
different
using
provide
a
theoretical
basis
for
further
promote
bone–implant
integration
in
future.
