Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101595 - 101595

Published: Feb. 19, 2025

Language: Английский

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Bone-targeted biomaterials: Strategies and applications

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 446, P. 137133 - 137133

Published: May 26, 2022

Language: Английский

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Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy

Theranostics, Journal Year: 2022, Volume and Issue: 12(15), P. 6576 - 6594

Published: Jan. 1, 2022

Bone and soft tissue tumors are complex mesenchymal neoplasms that seriously endanger human health. Over the past decade, relationship between microorganisms health diseases is getting more attention. The extracellular vesicles derived from bacteria have been shown to regulate bacterial-host cell communication by transferring their contents, including nucleic acids, proteins, metabolites, lipopolysaccharides, peptidoglycans. Bacteria (BEVs) promising lipid-bilayer nanocarriers for treatment of many due low toxicity, drug loading capacity, ease modification industrialization. Specially, BEVs-based cancer therapy has attracted much attention because ability effectively stimulate immune responses. In this review, we provide an overview biogenesis, composition, isolation, classification, internalization BEVs. We then comprehensively summarize sources BEVs in BEVs-related strategies. further highlight great potential bone tumors. Finally, conclude major advantages challenges therapy. believe comprehensive understanding field will generate innovative solutions achieve clinical applications.

Language: Английский

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Advances in Single-component inorganic nanostructures for photoacoustic imaging guided photothermal therapy

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 192, P. 114644 - 114644

Published: Dec. 6, 2022

Language: Английский

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Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: May 31, 2022

Targeted delivery by either systemic or local targeting of therapeutics to the bone is an attractive treatment for various metabolism diseases such as osteoporosis, osteoarthritis, osteosarcoma, osteomyelitis, etc. To overcome limitations direct drug delivery, combination bone-targeted agents with nanotechnology has opportunity provide a more effective therapeutic approach, where engineered nanoparticles cause accumulate in bone, thereby improving efficacy and minimizing side effects. Here, we summarize current advances bone-targeting approaches nanosystem applications diseases, which may new insights into nanocarrier-delivered drugs targeted diseases. We envision that novel carriers developed based on will be potential vehicle currently incurable are expected translated clinical applications.

Language: Английский

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Scaffold Fabrication Techniques of Biomaterials for Bone Tissue Engineering: A Critical Review

Bioengineering, Journal Year: 2022, Volume and Issue: 9(12), P. 728 - 728

Published: Nov. 24, 2022

Bone tissue engineering (BTE) is a promising alternative to repair bone defects using biomaterial scaffolds, cells, and growth factors attain satisfactory outcomes. This review targets the fabrication of such as conventional electrohydrodynamic techniques, for treatment an autograft, allograft, xenograft sources. Additionally, modern approaches fabricating constructs by additive manufacturing, injection molding, microsphere-based sintering, 4D printing providing favorable environment regeneration, function, viability, are thoroughly discussed. The polymers used, methods, advantages, limitations in application also emphasized. provides future outlook regarding potential BTE well its possibilities clinical trials.

Language: Английский

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Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle

Bioactive Materials, Journal Year: 2022, Volume and Issue: 20, P. 166 - 178

Published: May 27, 2022

Skeletal muscle disorders have posed great threats to health. Selective delivery of drugs and oligonucleotides skeletal is challenging. Aptamers can improve targeting efficacy. In this study, for the first time, human muscle-specific ssDNA aptamers (HSM01, etc.) were selected identified with Systematic Evolution Ligands by Exponential Enrichment (SELEX). The HSM01 aptamer preferentially interacted cells

Language: Английский

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Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 20 - 39

Published: Nov. 29, 2022

Currently, biological membrane-derived nanoparticles (NPs) have shown enormous potential as drug delivery vehicles due to their outstanding biomimetic properties.To make these NPs more adaptive complex systems, some methods been developed modify biomembranes and endow them with functions while preserving inherent natures.In this review, we introduce five common approaches used for biomembrane decoration: membrane hybridization, the postinsertion method, chemical methods, metabolism engineering gene engineering.These can functionalize a series of derived from red blood cells, white tumor platelets, exosomes so on.Biomembrane could markedly facilitate targeted delivery, treatment diagnosis cancer, inflammation, immunological diseases, bone diseases Alzheimer's disease.It is anticipated that modification techniques will advance biomembrane-derived into broader applications in future.

Language: Английский

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Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(9), P. 3507 - 3522

Published: Jan. 1, 2023

Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it is still a great challenge to improve the repair of articular cartilage due limited self-regeneration capacity such defects. Herein, novel ROS-responsive in situ nanocomposite hydrogel loaded with kartogenin (KGN) bone marrow-derived stem cells (BMSCs) was designed constructed via enzymatic reaction fibrinogen thrombin. Meanwhile, thioketal (TK)-based liposome synthesized load chondrogenesis-inducing factor KGN, bioenzyme thrombin an ultrasound-sensitive agent PpIX. Under ultrasound stimulation, TK-based destroyed, followed gelation Moreover, sustained release KGN realized regulating conditions. Importantly, ROS generation within microenvironment fibrin significantly promoted chondrogenic differentiation BMSCs Smad5/mTOR signalling pathway effectively improved regeneration rat defect model. Overall, ROS-controlled drug has potential for efficient repair.

Language: Английский

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Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1069 - 1069

Published: May 17, 2022

Titanium and its alloys are the most widely applied orthopedic dental implant materials due to their high biocompatibility, superior corrosion resistance, outstanding mechanical properties. However, lack of osseointegration remains main obstacle successful implantation. Previous traditional surface modification methods titanium-based implants cannot fully meet clinical needs osseointegration. The construction local drug delivery systems (e.g., antimicrobial systems, anti-bone resorption etc.) on has been proved be an effective strategy improve Meanwhile, these can also combined with methods, such as anodic oxidation, acid etching, coating technology, etc., achieve desirable enhanced In this paper, we review research progress different using provide a theoretical basis for further promote bone–implant integration in future.

Language: Английский

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