Abstract
Solar
energy
conversion
technologies,
particularly
solar‐driven
photothermal
conversion,
are
both
clean
and
manageable.
Although
much
progress
has
been
made
in
designing
materials,
significant
challenges
remain,
not
least
the
photobleaching
of
organic
dyes.
To
tackle
these
issues,
micro‐carbonized
polysaccharide
chains,
with
carbon
dots
(CDs)
suspended
from
conceived,
just
like
grapes
or
tomatoes
hanging
a
vine.
Carbonization
sodium
carboxymethyl
cellulose
(CMC)
produces
such
structure
(termed
CMC‐g‐CDs),
which
is
used
to
produce
an
ultra‐stable,
robust,
efficient
solar‐thermal
film
by
interfacial
interactions
within
CMC‐g‐CDs.
The
introduction
CDs
into
matrix
material
effectively
avoided
problem
photobleaching.
Manipulating
(such
as
electrostatic
interactions,
van
der
Waals
π–π
stacking,
hydrogen
bonding)
between
polymer
chains
markedly
enhances
mechanical
properties
film.
CMC‐g‐CDs
complexed
Fe
3+
eliminate
leakage
reagent
solve
poor
water
resistance.
resulting
(CMC‐g‐CDs‐Fe)
excellent
prospects
for
practical
application
RSC Advances,
Год журнала:
2023,
Номер
13(21), С. 14443 - 14460
Опубликована: Янв. 1, 2023
This
review
summarizes
the
common
inorganic
and
organic
photothermal
nanoagents
their
applications
in
tumor
therapy.
Additionally,
challenges
future
prospects
of
nanomaterial-based
therapy
cancer
treatment
are
discussed.
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
Advanced Materials,
Год журнала:
2024,
Номер
36(27)
Опубликована: Март 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Biomaterials Science,
Год журнала:
2023,
Номер
11(13), С. 4411 - 4429
Опубликована: Янв. 1, 2023
A
review
discusses
the
recent
applications
of
Prussian
blue
nanomaterials
in
photothermal
treatment
and
photothermal-based
multimodal
cancer
treatment.
Additionally,
potential
obstacles
to
future
research
clinical
translation
are
discussed.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11439 - 11439
Опубликована: Июль 14, 2023
Management
of
chronic
inflammation
and
wounds
has
always
been
a
key
issue
in
the
pharmaceutical
healthcare
sectors.
Curcumin
(CCM)
is
an
active
ingredient
extracted
from
turmeric
rhizomes
with
antioxidant,
anti-inflammatory,
antibacterial
activities,
thus
showing
significant
effectiveness
toward
wound
healing.
However,
its
shortcomings,
such
as
poor
water
solubility,
chemical
stability,
fast
metabolic
rate,
limit
bioavailability
long-term
use.
In
this
context,
hydrogels
appear
to
be
versatile
matrix
for
carrying
stabilizing
drugs
due
their
biomimetic
structure,
soft
porous
microarchitecture,
favorable
biomechanical
properties.
The
drug
loading/releasing
efficiencies
can
also
controlled
via
using
highly
crystalline
metal-organic
frameworks
(MOFs).
Herein,
flexible
hydrogel
composed
sodium
alginate
(SA)
CCM-loaded
MOFs
was
constructed
release
activity.
morphology
physicochemical
properties
composite
were
analyzed
by
scanning
electron
microscopy
(SEM),
Fourier
transform
infrared
spectroscopy
(FT-IR),
X-ray
diffraction
(XRD),
ultraviolet-visible
(UV-Vis),
Raman
spectroscopy,
mechanical
property
tests.
results
showed
that
twistable
bendable
comply
human
skin
mechanically.
as-prepared
could
capture
efficient
CCM
slow
effectively
kill
bacteria.
Therefore,
expected
provide
new
management
system
dressings.
Abstract
Organic
diradicaloids
with
unique
open‐shell
structures
and
properties
have
been
widely
used
in
organic
electronics
spintronics.
However,
their
advantageous
optical
explored
less
the
biomedical
field.
In
this
work,
photothermal
conversion
behaviors
of
a
boron‐containing
diradicaloid
(BOD)
are
reported.
BOD
can
assemble
1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐poly(ethylene
glycol)
to
form
rodlike
nanoparticles
(BOD
NPs).
These
as‐prepared
NPs
exhibit
high
capability
robust
stability.
Notably,
they
possess
morphological
superiority,
which
guarantees
effective
therapy
tumors.
This
work
thus
demonstrates
promise
as
efficient
agents
for
applications.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 5, 2024
Abstract
To
advance
the
understanding
and
potential
treatment
strategies
for
triple‐negative
breast
cancer
(TNBC),
particularly
focusing
on
its
high
metastatic
propensity
uncertain
molecular
targets,
a
biomimetic
tumor
cell
membrane‐encapsulated
nanodelivery
system
is
developed
enhanced
immunotherapy.
This
assembled
with
second
near‐infrared
(NIR‐II)
photothermal
agent,
chemotherapeutic
drug,
programmed
death‐ligand
1
(PD‐L1)
inhibitors
camouflaged
by
TNBC
membranes.
An
NIR‐II
Ag
2
S
quantum
dots
(QDs)
introduced
not
only
realizing
pronounced
imaging‐guided
therapy
(PTT),
but
also
co‐activating
immunogenic
death
(ICD)
chemotherapy.
Homologous
targeting
camouflage
properties
endowed
excellent
biocompatibility
efficient
delivery
ability
to
site,
demonstrating
synergistic
therapeutic
efficacy.
The
release
of
damage‐associated
patterns
(DAMP)
marked
induction
ICD,
crucial
reshaping
immune
microenvironment.
Further
integration
α‐PD‐L1
achieved
56.5%
checkpoint
inhibition
rate,
synergistically
amplifying
response
ultimately
activate
key
cytokines,
thereby
achieving
anti‐tumor
immunotherapy
effects.
Notably,
this
approach
realized
considerable
reduction
nodules
51.2%
in
lung
metastasis
model.
proposed
extended
remission
effectively
reduced
metastasis,
paving
way
reliable
promising
Abstract
Intracellular
delivery
of
nano‐drug‐carriers
(NDC)
to
specific
cells,
diseased
regions,
or
solid
tumors
has
entered
the
era
precision
medicine
that
requires
systematic
knowledge
nano‐biological
interactions
from
multidisciplinary
perspectives.
To
this
end,
review
first
provides
an
overview
membrane‐disruption
methods
such
as
electroporation,
sonoporation,
photoporation,
microfluidic
delivery,
and
microinjection
with
merits
high‐throughput
enhanced
efficiency
for
in
vitro
NDC
delivery.
The
impact
characteristics
including
particle
size,
shape,
charge,
hydrophobicity,
elasticity
on
cellular
uptake
are
elaborated
several
types
systems
aiming
hierarchical
targeting
vivo
reviewed.
Emerging
ex
human/animal‐derived
pathophysiological
models
further
explored
highly
recommended
use
studies
since
they
might
mimic
features
fill
translational
gaps
animals
humans.
exploration
modern
microscopy
techniques
precise
nanoparticle
(NP)
tracking
at
cellular,
organ,
organismal
levels
informs
tailored
development
NDCs
application
clinical
translation.
Overall,
integrates
latest
insights
into
smart
nanosystem
engineering,
physiological
models,
imaging‐based
validation
tools,
all
directed
towards
enhancing
efficient
intracellular
NDCs.
