Composites Part B Engineering,
Год журнала:
2024,
Номер
275, С. 111280 - 111280
Опубликована: Фев. 5, 2024
Intervertebral
disc
degeneration
(IVDD)
plays
a
pivotal
etiological
role
in
low
back
pain,
which
is
global
cause
of
disability.
Although
the
underlying
pathological
processes
and
mechanisms
IVDD
are
complex,
oxidative
stress
extracellular
matrix
degradation
recognized
as
crucial
determinants
degeneration.
The
delicate
equilibrium
between
reactive
oxygen
species
antioxidants
holds
profound
significance
maintaining
normal
cellular
functions,
while
maintains
intervertebral
stability.
This
study
developed
bioadhesive
with
mechanical
properties
similar
to
those
nucleus
pulposus,
an
injectable
hydrogel.
Unlike
other
antioxidative
drug
carrier
materials,
this
hydrogel
achieved
removal
through
material
loaded
transforming
growth
factor-beta
3
gradually
released
regulate
matrix.
Cellular
experiments
demonstrated
ability
scavenge
radicals,
stimulate
pulposus
cell
migration,
collagen
secretion.
Moreover,
radiographic
histological
analyses
needle-induced
rat-tail
model
confirmed
potential
restore
height,
maintain
hydration,
preserve
tissue
structure,
promote
These
findings
have
promising
implications
for
efficacy
hydrogels
ameliorating
IVDD.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1829 - 1829
Опубликована: Июнь 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Апрель 27, 2024
Abstract
An
asymmetrical
wound
dressing
functions
akin
to
human
skin
by
serving
as
a
protective
barrier
between
and
its
immediate
environment.
However,
significant
challenges
persist
concerning
the
robust
adhesion
properties
of
hydrogels,
particularly
when
applied
in
emergency
hemostasis
healing
contexts.
Herein,
study
has
successfully
synthesized
hydrogel
patches
with
Janus
asymmetric‐adhesion,
denoted
HGO‐C,
exclusively
comprised
natural
polymers.
This
achievement
is
realized
through
assembly
adhesive
(HGO)
non‐adhesive
(CGC),
thereby
amalgamating
their
distinct
functionalities.
The
component
served
physical
shield
safeguarding
against
contamination,
while
hydrogel,
contacted
surface,
firmly
adhered
it,
swiftly
arresting
bleeding
facilitating
healing.
Cytocompatibility
tests,
hemolysis
antibacterial
assays,
coagulation
assays
demonstrated
excellent
biocompatibility,
antibacterial,
hemostatic
HGO‐C.
Finally,
vivo
experiments,
including
liver
hemorrhage
assay
assay,
unequivocally
showed
rapid
enhanced
capabilities
Consequently,
these
distinctive
patches,
derived
from
polymers
characterized
asymmetric
properties,
may
have
great
potential
for
real‐life
usage
clinical
patients.
Nano Materials Science,
Год журнала:
2024,
Номер
6(4), С. 375 - 395
Опубликована: Янв. 10, 2024
Marine
biofouling
seriously
affects
human
marine
exploitation
and
transportation
activities,
to
which
antifouling
(AF)
coatings
are
considered
be
the
most
cost-effective
solution.
Since
mid-20th
century,
beings
have
dedicated
their
efforts
on
developing
AF
with
long
cycle
high
performance,
leading
a
large
number
of
non-target
organisms'
distortion,
death
environmental
pollution.
Polydimethylsiloxane
(PDMS),
is
as
one
representative
environment-friendly
materials
thanks
its
non-toxic,
hydrophobic,
low
surface
energy
properties.
However,
PDMS
prone
mechanical
damage,
weak
adhesion
strength
substrate,
poor
static
effect,
restrict
use
in
ocean.
The
rapid
development
various
nanomaterials
provides
an
opportunity
enhance
improve
properties
coating
by
embedding
nanomaterials.
Based
our
research
background
problems
faced
laboratory,
this
article
presents
overview
current
progress
fields
composite
enhanced
different
nanomaterials,
discussion
focused
advantages
main
bottlenecks
currently
encountered
field.
Finally,
we
propose
outlook,
hoping
provide
fundamental
guidance
for
