Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes DOI Creative Commons
Junchol Park,

James W. Phillips,

Jian‐Zhong Guo

и другие.

Science Advances, Год журнала: 2022, Номер 8(10)

Опубликована: Март 9, 2022

The interaction of descending neocortical outputs and subcortical premotor circuits is critical for shaping skilled movements. Two broad classes motor cortical output projection neurons provide input to many areas: pyramidal tract (PT) neurons, which project throughout the neuraxis, intratelencephalic (IT) within cortex striatum. It unclear whether these are functionally in series or each class carries distinct components control signals. Here, we combine large-scale neural recordings across all layers with cell type-specific perturbations study cortically dependent mouse behaviors: kinematically variable manipulation a joystick precise reach-to-grasp. We find that striatum-projecting IT neuron activity preferentially represents amplitude, whereas pons-projecting PT represent direction forelimb Thus, separable commands distributed classes.

Язык: Английский

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors DOI Open Access
Tommaso Patriarchi, Jounhong Ryan Cho, Katharina Merten

и другие.

Science, Год журнала: 2018, Номер 360(6396)

Опубликована: Май 31, 2018

Imaging dopamine release in the brain Neuromodulator alters function of target circuits poorly known ways. An essential step to address this knowledge gap is measure dynamics neuromodulatory signals while simultaneously manipulating elements circuit during behavior. Patriarchi et al. developed fluorescent protein–based indicators visualize spatial and temporal directly with high fidelity resolution. In cortex, two-photon imaging these was used map activity at cellular Science , issue p. eaat4422

Язык: Английский

Процитировано

987

The basal ganglia and the cerebellum: nodes in an integrated network DOI
Andreea C. Bostan, Peter L. Strick

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(6), С. 338 - 350

Опубликована: Апрель 11, 2018

Язык: Английский

Процитировано

663

What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation DOI Open Access
Andreas Klaus, Joaquim Alves da Silva, Rui M. Costa

и другие.

Annual Review of Neuroscience, Год журнала: 2019, Номер 42(1), С. 459 - 483

Опубликована: Апрель 24, 2019

Deciding what to do and when move is vital our survival. Clinical fundamental studies have identified basal ganglia circuits as critical for this process. The main input nucleus of the ganglia, striatum, receives inputs from frontal, sensory, motor cortices interconnected thalamic areas that provide information about potential goals, context, actions directly or indirectly modulates outputs. striatum also dopaminergic can signal reward prediction errors behavioral transitions movement initiation. Here we review models how direct indirect pathways modulate outputs facilitate initiation, discuss role cortical in determining if it. Complex but exciting scenarios emerge shed new light on self-paced

Язык: Английский

Процитировано

266

The Spatiotemporal Organization of the Striatum Encodes Action Space DOI Creative Commons
Andreas Klaus, Gabriela J. Martins, Vítor Paixão

и другие.

Neuron, Год журнала: 2017, Номер 95(5), С. 1171 - 1180.e7

Опубликована: Авг. 1, 2017

Язык: Английский

Процитировано

255

The Spatiotemporal Organization of the Striatum Encodes Action Space DOI Creative Commons
Andreas Klaus, Gabriela J. Martins, Vítor Paixão

и другие.

Neuron, Год журнала: 2017, Номер 96(4), С. 949 - 949

Опубликована: Ноя. 1, 2017

Язык: Английский

Процитировано

217

The Basal Ganglia Do Not Select Reach Targets but Control the Urgency of Commitment DOI Creative Commons
David Thura, Paul Cisek

Neuron, Год журнала: 2017, Номер 95(5), С. 1160 - 1170.e5

Опубликована: Авг. 1, 2017

Язык: Английский

Процитировано

198

Midbrain Dopamine Neurons Signal Belief in Choice Accuracy during a Perceptual Decision DOI Creative Commons
Armin Lak, Kensaku Nomoto, Mehdi Keramati

и другие.

Current Biology, Год журнала: 2017, Номер 27(6), С. 821 - 832

Опубликована: Март 1, 2017

Язык: Английский

Процитировано

189

The role of dopamine in the brain - lessons learned from Parkinson's disease DOI Creative Commons
David Meder, Damian M. Herz, James B. Rowe

и другие.

NeuroImage, Год журнала: 2018, Номер 190, С. 79 - 93

Опубликована: Ноя. 20, 2018

Parkinson's disease causes a characteristic combination of motor symptoms due to progressive neurodegeneration dopaminergic neurons in the substantia nigra pars compacta. The core impairment neurotransmission has motivated use functional magnetic resonance imaging (fMRI) patients with elucidate role dopamine control and cognition humans. Here we review main insights from brain disease. Task-related fMRI revealed many disease-related alterations activation patterns. However, interpretation these findings is complicated by fact that task-dependent activity influenced complex interactions between amount task-relevant nuclei, state medication, genetic factors performance. Despite ambiguities, studies demonstrated central generation movement vigour (bradykinesia) excessive movements (dyskinesia), involving changes both connectivity putamen, premotor regions, right inferior frontal gyrus (rIFG). addressing cognitive flexibility provided convergent evidence for non-linear, U-shaped, relationship levels nuclei pharmacological replacement can therefore move performance either away or towards task-specific optimum. Dopamine also strongly affect processing reward punishment optimal learning. further are needed detailed understanding mechanisms underlying effects. • (PD) results neurons. Functional MRI examines human brain. Evidence point securing vigour. show an inverse U-shape relationship. learning rewards punishments.

Язык: Английский

Процитировано

173

Movement Vigor as a Reflection of Subjective Economic Utility DOI Creative Commons
Reza Shadmehr, Thomas R. Reppert, Erik M. Summerside

и другие.

Trends in Neurosciences, Год журнала: 2019, Номер 42(5), С. 323 - 336

Опубликована: Март 13, 2019

Язык: Английский

Процитировано

160

Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor DOI Creative Commons
Abraham G. Beyene, Kristen Delevich, Jackson Travis Del Bonis-O’Donnell

и другие.

Science Advances, Год журнала: 2019, Номер 5(7)

Опубликована: Июль 5, 2019

A near infrared fluorescent probe enables high spatial resolution imaging of dopamine release in striatal brain tissue.

Язык: Английский

Процитировано

158