Input signal accumulation capability of the FitzHugh–Nagumo neuron DOI
Andrei V. Bukh, Igor A. Shepelev, Т. Е. Вадивасова

и другие.

Chaos An Interdisciplinary Journal of Nonlinear Science, Год журнала: 2024, Номер 34(12)

Опубликована: Дек. 1, 2024

We present numerical results on the effects of two presynaptic FitzHugh–Nagumo neurons a postsynaptic neuron under unidirectional electrical coupling. The affect not simultaneously but with certain time shift. consider cases where amplitudes spikes can be both higher and lower than excitation threshold level. latter case receives main attention in our work. carefully examine conditions which is excited by asynchronous external spikes. With arbitrarily chosen parameters, almost incapable accumulating energy signals, unlike, for example, leaky integrate-and-fire neuron. In this case, only excites very short delay between impulses. However, we have discovered, first time, parameter region possible even significant delays impulses subthreshold amplitudes. explain effect detail describe mechanism behind its occurrence. identify boundaries plane coupling coefficient varying control values neurons. has previously been used as node spiking neural networks training via spike-timing-dependent plasticity due to lack an effect. detection range parameters makes potential application STDP possible.

Язык: Английский

Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus DOI Creative Commons
Pavel P. Tregub, Yulia K. Komleva,

Maria V. Kukla

и другие.

Cells, Год журнала: 2025, Номер 14(2), С. 143 - 143

Опубликована: Янв. 19, 2025

Brain plasticity is at the basis of many cognitive functions, including learning and memory. It includes several mechanisms synaptic extrasynaptic changes, neurogenesis, formation elimination synapses. The transmission involves expression immediate early genes (IEGs) that regulate neuronal activity, thereby supporting In addition, IEGs are involved in regulation brain cells’ metabolism, proliferation, survival, establishment multicellular ensembles, and, presumably, cell competition tissue. this review, we analyze current understanding role (c-Fos, c-Myc, Arg3.1/Arc) controlling physiological pathological conditions, aging neurodegeneration. This work might inspire new gene therapy strategies targeting to plasticity, potentially prevent or mitigate neurodegenerative diseases.

Язык: Английский

Процитировано

2
Synaptic plasticity in human thalamocortical assembloids DOI Creative Commons
Mary H. Patton,

Kristen T. Thomas,

Ildar T. Bayazitov

и другие.

Cell Reports, Год журнала: 2024, Номер 43(8), С. 114503 - 114503

Опубликована: Июль 16, 2024

Synaptic plasticities, such as long-term potentiation (LTP) and depression (LTD), tune synaptic efficacy are essential for learning memory. Current studies of plasticity in humans limited by a lack adequate human models. Here, we modeled the thalamocortical system fusing induced pluripotent stem cell-derived thalamic cortical organoids. Single-nucleus RNA sequencing revealed that >80% cells organoids were glutamatergic neurons. When fused to form assembloids, formed reciprocal long-range axonal projections synapses detectable light electron microscopy, respectively. Using whole-cell patch-clamp electrophysiology two-photon imaging, characterized transmission. Thalamocortical corticothalamic displayed short-term analogous animal LTP LTD reliably at both synapses; however, their mechanisms differed from those previously described rodents. Thus, assembloids provide model exploring circuits.

Язык: Английский

Процитировано

8
The Effectiveness of Paired Associative Stimulation on Motor Recovery after Stroke: A Scoping Review DOI Creative Commons
Andrea Baroni, Annibale Antonioni, Giulia Fregna

и другие.

Neurology International, Год журнала: 2024, Номер 16(3), С. 567 - 589

Опубликована: Май 14, 2024

Paired associative stimulation (PAS) is a non-invasive brain technique combining transcranial magnetic and peripheral nerve stimulation. PAS allows connections between cortical areas nerves (C/P PAS) or regions (C/C to be strengthened weakened by spike-timing-dependent neural plasticity mechanisms. Since modulates both neurophysiological features motor performance, there growing interest in its application neurorehabilitation. We aimed synthesize evidence on the rehabilitation role of stroke patients. performed literature search following PRISMA Extension for Scoping Reviews Framework. Eight studies were included: one investigated C/C cerebellum affected primary area (M1), seven applied C/P over lesional, contralesional, M1. Seven evaluated outcome upper limb lower recovery. Although several omit crucial methodological details, highlighted effects mainly corticospinal excitability, and, more rarely, an improvement performance. However, most failed prove correlation changes improvement. current seem suggest post-stroke rehabilitation, their heterogeneity limited number do not yet allow definitive conclusions drawn.

Язык: Английский

Процитировано

7
Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling DOI Open Access
Aurore Thomazeau, Sabine Rannio, Jennifer A Brock

и другие.

Опубликована: Апрель 8, 2025

In the textbook view, NMDA receptors (NMDARs) act as coincidence detectors in Hebbian plasticity by fluxing Ca 2+ when simultaneously depolarized and glutamate bound. detection requires that NMDARs be located postsynaptically, but enigmatic presynaptic (preNMDARs) also exist. It is known preNMDARs regulate neurotransmitter release, precisely how remains poorly understood. Emerging evidence suggest can signal non-ionotropically, without need for flux. At synapses between developing visual cortex layer-5 (L5) pyramidal cells (PCs), rely on Mg Rab3-interacting molecule 1αβ (RIM1αβ) to evoked release during periods of high-frequency firing, they non-ionotropically via c-Jun N-terminal kinase 2 (JNK2) spontaneous regardless frequency. same synapses, timing- dependent long-term depression (tLTD) depends not We therefore tested if tLTD relies non-ionotropic preNMDAR signaling. found at L5 PC→PC was abolished pre- postsynaptic NMDAR deletion, cementing view preNMDARs. agreement with signaling, prevailed after channel pore blockade MK-801, unlike tLTP. Homozygous RIM1αβ deletion did affect tLTD, wash-in JNK2 blocker SP600125 tLTD. Consistent a JNK2, peptide blocking interaction Syntaxin-1a (STX1a) loaded Finally, low-frequency blocked nor 7-CK, non-competitive antagonist co-agonist site. conclude neocortical signaling JNK2/STX1a. Our study brings closure long-standing controversy surrounding highlights ionotropic needs reassessed.

Язык: Английский

Процитировано

1
Effects of spike-time-dependent plasticity on stochastic resonance in excitatory-inhibitory neuronal networks DOI
Xueqin Wang, Dong Yu, Tianyu Li

и другие.

Nonlinear Dynamics, Год журнала: 2024, Номер 112(14), С. 12435 - 12448

Опубликована: Май 9, 2024

Язык: Английский

Процитировано

6
Daily oscillations of neuronal membrane capacitance DOI Creative Commons
Daniel Severín,

Cristián Moreno,

Trinh Tran

и другие.

Cell Reports, Год журнала: 2024, Номер 43(10), С. 114744 - 114744

Опубликована: Сен. 17, 2024

Язык: Английский

Процитировано

6
Editorial overview: Neurobiology of learning and plasticity DOI
Thomas J. McHugh,

Mu‐ming Poo

Current Opinion in Neurobiology, Год журнала: 2023, Номер 81, С. 102734 - 102734

Опубликована: Июнь 4, 2023

Язык: Английский

Процитировано

12
The neuromorphic computing for biointegrated electronics DOI Open Access

Soon Joo Yoon,

Jin Tae Park,

Youn‐Kyoung Lee

и другие.

Soft Science, Год журнала: 2024, Номер 4(3)

Опубликована: Авг. 16, 2024

This review investigates the transformative potential of neuromorphic computing in advancing biointegrated electronics, with a particular emphasis on applications medical sensing, diagnostics, and therapeutic interventions. By examining convergence edge principles, we explore how emulating operational principles human brain can enhance energy efficiency functionality electronics. The begins an introduction to recent breakthroughs materials circuit designs that aim mimic various aspects biological nervous system. Subsequent sections synthesize demonstrations systems designed augment healthcare-related electronic systems, including those capable direct signal communication tissues. devices remain nascent stage, relatively limited number publications available. current aims meticulously summarize these pioneering studies evaluate state propose future directions advance interdisciplinary field.

Язык: Английский

Процитировано

5
Enhancing orderly signal propagation between layers of neuronal networks through spike timing-dependent plasticity DOI
Yonghong Wu, Weifang Huang, Qianming Ding

и другие.

Physics Letters A, Год журнала: 2024, Номер 519, С. 129721 - 129721

Опубликована: Июль 16, 2024

Язык: Английский

Процитировано

4
Contribution of membrane-associated oscillators to biological timing at different timescales DOI Creative Commons
Monika Stengl, Anna C. Schneider

Frontiers in Physiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 9, 2024

Environmental rhythms such as the daily light-dark cycle selected for endogenous clocks. These clocks predict regular environmental changes and provide basis well-timed adaptive homeostasis in physiology behavior of organisms. Endogenous are oscillators that based on positive feedforward negative feedback loops. They generate stable even under constant conditions. Since weak interactions between allow autonomous synchronization, coupling/synchronization provides self-organized physiological timing. Amongst most thoroughly researched circadian clock neurons mammals insects. comprise nuclear clockworks transcriptional/translational loops (TTFL) ∼24 h gene expression entrained to day-night cycle. It is generally assumed this TTFL clockwork drives all oscillations within cells, being any rhythm Instead current gene-based hierarchical model we here a systems view We suggest coupled system posttranslational loop (PTFL) oscillators/clocks run at multiple timescales governs adaptive, dynamic behavior. focus mammalian insect timescales. neuronal plasma membrane-associated signalosomes constitute specific PTFL localized but interlinked membrane potential intracellular messengers with frequencies. In each neuron multiscale form temporally structured oscillatory network common complex frequency-band comprising superimposed oscillations. Coupling oscillator/clock next level complexity an network. This systemic molecular cellular suggested cycles through homeostatic setpoints characteristic hallmark. propose mechanisms plasticity maintain stability these setpoints, whereas Hebbian enables switching via coupling factors, like biogenic amines and/or neuropeptides. reprogram new frequency, setpoint. Our novel hypothesis up experimental challenge.

Язык: Английский

Процитировано

3