Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6389 - 6389
Опубликована: Июнь 9, 2024
Long
COVID
(LC),
also
referred
to
as
Post
COVID-19
Condition,
Post-Acute
Sequelae
of
SARS-CoV-2
Infection
(PASC),
and
other
terms,
represents
a
complex
multisystem
disease
persisting
after
the
acute
phase
COVID-19.
Characterized
by
myriad
symptoms
across
different
organ
systems,
LC
presents
significant
diagnostic
management
challenges.
Central
disorder
is
role
low-grade
inflammation,
non-classical
inflammatory
response
that
contributes
chronicity
diversity
observed.
This
review
explores
pathophysiological
underpinnings
LC,
emphasizing
importance
inflammation
core
component.
By
delineating
pathogenetic
relationships
clinical
manifestations
this
article
highlights
necessity
for
an
integrated
approach
employs
both
personalized
medicine
standardized
protocols
aimed
at
mitigating
long-term
consequences.
The
insights
gained
not
only
enhance
our
understanding
but
inform
development
therapeutic
strategies
could
be
applicable
chronic
conditions
with
similar
features.
Язык: Английский
A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1545 - 1545
Опубликована: Май 21, 2024
Myalgic
encephalomyelitis,
also
known
as
chronic
fatigue
syndrome
(ME/CFS),
and
long
COVID
are
complex,
multisystemic
long-term
disabling
conditions
characterized
by
debilitating
post-exertional
malaise
other
core
symptoms
related
to
immune
dysregulation
resultant
from
post-viral
infection,
including
mitochondrial
dysfunction,
neuroinflammation
gut
dysbiosis.
The
reported
associations
between
altered
microbiota
composition
cardinal
of
ME/CFS
suggest
that
the
use
microbial
preparations,
such
probiotics,
restoring
homeostasis
brain–immune–gut
axis,
may
help
in
management
both
conditions.
Therefore,
this
review
aims
investigate
implications
alerted
microbiome
assess
evidence
supporting
microbial-based
synbiotics,
postbiotics
alone
and/or
combination
with
nutraceuticals
fatigue,
inflammation
neuropsychiatric
gastrointestinal
among
patients
COVID.
Язык: Английский
The gut microbiome in post-COVID syndrome patients
The Innovation Medicine,
Год журнала:
2025,
Номер
unknown, С. 100123 - 100123
Опубликована: Янв. 1, 2025
<p>Post-COVID
syndrome
(PCS)
is
a
debilitating
condition
that
affects
significant
number
of
COVID-19
survivors
worldwide.
PCS
characterized
by
persistent
symptoms
such
as
fatigue,
shortness
breath,
cognitive
impairment,
and
gastrointestinal
issues.
The
frequent
occurrence
has
prompted
researchers
to
investigate
the
role
gut
microbiota
in
development
progression
PCS.
This
review
synthesizes
findings
from
recent
studies,
providing
comprehensive
overview
changes
both
patients
patients.
Evidence
suggests
can
cause
lasting
alterations
microbiota,
marked
reduced
microbial
diversity,
an
increase
opportunistic
pathogens,
decrease
beneficial
bacteria
support
immune
metabolic
health.
In
addition,
host-microbe
interactions
gut-lung,
gut-brain,
gut-heart
axes
are
explored
understand
impact
microbes
on
systemic
Finally,
potential
diagnostic
therapeutic
strategies
for
discussed,
including
use
probiotics,
prebiotics,
fecal
transplantation
(FMT)
restore
balance
alleviate
symptoms.</p>
Язык: Английский
Pathogen Discovery in the Post-COVID Era
Pathogens,
Год журнала:
2024,
Номер
13(1), С. 51 - 51
Опубликована: Янв. 5, 2024
Pathogen
discovery
plays
a
crucial
role
in
the
fields
of
infectious
diseases,
clinical
microbiology,
and
public
health.
During
past
four
years,
global
response
to
COVID-19
pandemic
highlighted
importance
early
accurate
identification
novel
pathogens
for
effective
management
prevention
outbreaks.
The
post-COVID
era
has
ushered
new
phase
disease
research,
marked
by
accelerated
advancements
pathogen
discovery.
This
review
encapsulates
recent
innovations
paradigm
shifts
that
have
reshaped
landscape
pandemic.
Primarily,
we
summarize
latest
technology
innovations,
applications,
causation
proving
strategies
enable
rapid
both
acute
historical
infections.
We
also
explored
significance
trends
approaches
being
employed
implementation
from
various
environmental
samples.
Furthermore,
emphasize
collaborative
nature
response,
which
led
establishment
networks
Язык: Английский
A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in ME/CFS: Implications for Long COVID
Опубликована: Май 1, 2024
Myalgic
Encephalomyelitis,
also
known
as
Chronic
Fatigue
Syndrome
(ME/CFS)
and
Long
COVID
are
characterized
by
debilitating
post-exertional
malaise
other
core
symptoms
related
to
immune
dysregulation
resultant
from
post-viral
infection,
including
mitochondrial
dysfunction,
chronic
neuroinflammation
gut
dysbiosis.
The
reported
associations
between
altered
microbiota
composition
cardinal
of
ME/CFS
COVID,
suggesting
that
use
microbial
preparations,
such
probiotics,
restoring
the
homeostasis
brain-immune-gut
axis
may
help
in
management
both
conditions.
Therefore,
this
review
aims
investigate
implications
alerted
microbiome
assess
evidence
supporting
microbial-based
synbiotics,
postbiotics
alone
and/or
combination
with
nutraceuticals
fatigue,
inflammation,
well
neuropsychiatric
gastrointestinal
among
patients
COVID.
Язык: Английский
Interplay between Multisystem Inflammatory Syndrome in Children, Interleukin 6, Microbiome, and Gut Barrier Integrity
Immuno,
Год журнала:
2024,
Номер
4(3), С. 226 - 246
Опубликована: Авг. 18, 2024
A
severe
consequence
of
SARS-CoV-2
infection
that
manifests
as
systemic
inflammation
and
multi-organ
involvement
is
called
Multisystem
Inflammatory
Syndrome
in
Children
(MIS-C).
This
review
examines
the
possible
relationship
between
gut
barrier
integrity,
microbiome,
dysregulation
interleukin
6
(IL-6)
signaling,
MIS-C.
Clinical
biochemical
features
MIS-C
are
comparable
to
those
other
hyper-inflammatory
syndromes,
suggesting
a
dysregulated
immune
response.
One
explanation
for
seen
patients
SARS-CoV-2-induced
IL-6
signaling
pathway.
In
addition,
new
data
suggest
reciprocal
link
integrity
IL-6.
exhibits
bacteriophage-like
behavior,
highlighting
role
bacteria
reservoir
virus
emphasizing
importance
understanding
bacteriophagic
mechanism
fecal–oral
transmission.
The
increased
translocation
viral
products
bacterial
toxins
may
result
from
disrupting
intestinal
cause
inflammation.
On
hand,
can
weaken
barrier,
which
feeds
back
into
loop
immunological
dysregulation.
context
MIS-C,
interaction
infection,
IL-6,
shed
light
on
etiology
disease
guide
treatment
options.
Since
children
with
dysbiosis
be
more
susceptible
it
critical
reinforce
their
microbiome
through
probiotics
supplementation,
plant-fiber-rich
diets
(prebiotics).
Early
antibiotic
use
zonulin
antagonists
should
also
considered.
Язык: Английский
Blood virome research in myalgic encephalomyelitis/chronic fatigue syndrome: challenges and opportunities
Current Opinion in Virology,
Год журнала:
2024,
Номер
68-69, С. 101437 - 101437
Опубликована: Сен. 1, 2024
Myalgic
encephalomyelitis/chronic
fatigue
syndrome
(ME/CFS)
is
a
debilitating
disease
with
complex
clinical
presentation
and
an
unknown
etiology.
Various
viral
infections
have
been
proposed
as
potential
triggers
of
ME/CFS
onset,
but
no
specific
pathogen
has
identified
in
all
cases
postinfectious
ME/CFS.
The
symptomatology
the
postacute
sequelae
SARS-CoV-2,
or
long
COVID,
mirrors
that
ME/CFS,
nearly
half
COVID
patients
meeting
diagnostic
criteria.
influx
newly
diagnosed
reinvigorated
interest
pathogenesis
research,
emphasis
on
triggers.
This
review
summarizes
current
understanding
research
triggers,
including
blood
virome
screening
studies.
To
further
elucidate
molecular
basis
there
need
to
develop
innovative
bioinformatics
tools
capable
analyzing
data
integrating
multiomics
information.
Язык: Английский