Optimization of drug solubility inside the supercritical CO2 system via numerical simulation based on artificial intelligence approach DOI Creative Commons

Meixiuli Li,

Wenyan Jiang, Shuang Zhao

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 1, 2024

Язык: Английский

Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO2: Experimental Analysis and Artificial Intelligence Study DOI

Oday Sajjad Alsawad,

Ahmad AlHamad, Carlos Rodriguez‐Benites

и другие.

Journal of Chemical & Engineering Data, Год журнала: 2024, Номер 69(7), С. 2569 - 2584

Опубликована: Июль 1, 2024

Assessing the solubility of pharmaceutical compounds in supercritical carbon dioxide (scCO2) is a fundamental prerequisite for advancing application technologies sector. The Febuxostat, drug with limited often prescribed gout patients to lower blood uric acid levels, has previously been studied within pressure and temperature ranges 12–27 MPa 308–338 K, exhibiting mole fraction range 0.05 × 10–4–7.42 10–4. This study explores influence various cosolvents, namely, ethanol, acetone, dimethyl sulfoxide (DMSO), on Febuxostat under comparable conditions. Results indicate 0.180 10–4–26.658 10–4 0.120 10–4–14.810 0.108 10–4–14.366 DMSO, respectively. Ethanol exhibits most substantial impact, enhancing by approximately 2.4–3.8 times, while acetone DMSO contribute an increase 2–2.5 times. Furthermore, employs empirical models artificial neural network (ANN) approach theoretically investigate these cosolvents. Among models, Jouyban model demonstrates accurate correlation data all Moreover, ANN exceptional accuracy forecasting mean AARD % 3.207% Radj 0.993 across experimental measurements scCO2 + solvents.

Язык: Английский

Процитировано

5
New solubility data of Amoxapine (anti-depressant) drug in supercritical CO2: Application of cubic EoSs DOI

Mina Tabebordbar,

Hamidreza Bagheri,

Munthar Kadhim Abosaoda

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106281 - 106281

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

4
Assessment of new semi-empirical density based model for prediction the solubility of pharmaceutical components in supercritical carbon dioxide DOI

C. Bouhallas,

A. Abdallah el hadj, Yamina Ammi

и другие.

The Journal of Supercritical Fluids, Год журнала: 2024, Номер 213, С. 106351 - 106351

Опубликована: Июль 20, 2024

Язык: Английский

Процитировано

3
Investigating the thermal enhancement of Levetiracetam solubility in the ternary system of supercritical carbon dioxide and ethanol DOI

Yahia Alghazwani,

Sirajunisa Talath, Farhat Fatima

и другие.

Journal of Molecular Liquids, Год журнала: 2024, Номер 411, С. 125692 - 125692

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

3
Metrological analysis on measuring techniques used to determine solubility of solids in supercritical carbon dioxide DOI
Fernando J. Pérez-Sanz,

Inma Mohino-Herranz,

Reinaldo C. Bazito

и другие.

Measurement, Год журнала: 2024, Номер 240, С. 115502 - 115502

Опубликована: Авг. 11, 2024

Язык: Английский

Процитировано

2
Optimization of drug solubility inside the supercritical CO2 system via numerical simulation based on artificial intelligence approach DOI Creative Commons

Meixiuli Li,

Wenyan Jiang, Shuang Zhao

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1