Optimization of drug solubility inside the supercritical CO2 system via numerical simulation based on artificial intelligence approach DOI Creative Commons

Meixiuli Li,

Wenyan Jiang, Shuang Zhao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 1, 2024

Language: Английский

Investigating the Influence of Cosolvents on the Solubility of Febuxostat in Supercritical CO2: Experimental Analysis and Artificial Intelligence Study DOI

Oday Sajjad Alsawad,

Ahmad AlHamad, Carlos Rodriguez‐Benites

et al.

Journal of Chemical & Engineering Data, Journal Year: 2024, Volume and Issue: 69(7), P. 2569 - 2584

Published: July 1, 2024

Assessing the solubility of pharmaceutical compounds in supercritical carbon dioxide (scCO2) is a fundamental prerequisite for advancing application technologies sector. The Febuxostat, drug with limited often prescribed gout patients to lower blood uric acid levels, has previously been studied within pressure and temperature ranges 12–27 MPa 308–338 K, exhibiting mole fraction range 0.05 × 10–4–7.42 10–4. This study explores influence various cosolvents, namely, ethanol, acetone, dimethyl sulfoxide (DMSO), on Febuxostat under comparable conditions. Results indicate 0.180 10–4–26.658 10–4 0.120 10–4–14.810 0.108 10–4–14.366 DMSO, respectively. Ethanol exhibits most substantial impact, enhancing by approximately 2.4–3.8 times, while acetone DMSO contribute an increase 2–2.5 times. Furthermore, employs empirical models artificial neural network (ANN) approach theoretically investigate these cosolvents. Among models, Jouyban model demonstrates accurate correlation data all Moreover, ANN exceptional accuracy forecasting mean AARD % 3.207% Radj 0.993 across experimental measurements scCO2 + solvents.

Language: Английский

Citations

5
New solubility data of Amoxapine (anti-depressant) drug in supercritical CO2: Application of cubic EoSs DOI

Mina Tabebordbar,

Hamidreza Bagheri,

Munthar Kadhim Abosaoda

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106281 - 106281

Published: Oct. 1, 2024

Language: Английский

Citations

4
Assessment of new semi-empirical density based model for prediction the solubility of pharmaceutical components in supercritical carbon dioxide DOI

C. Bouhallas,

A. Abdallah el hadj, Yamina Ammi

et al.

The Journal of Supercritical Fluids, Journal Year: 2024, Volume and Issue: 213, P. 106351 - 106351

Published: July 20, 2024

Language: Английский

Citations

3
Investigating the thermal enhancement of Levetiracetam solubility in the ternary system of supercritical carbon dioxide and ethanol DOI

Yahia Alghazwani,

Sirajunisa Talath, Farhat Fatima

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 411, P. 125692 - 125692

Published: Aug. 3, 2024

Language: Английский

Citations

3
Metrological analysis on measuring techniques used to determine solubility of solids in supercritical carbon dioxide DOI
Fernando J. Pérez-Sanz,

Inma Mohino-Herranz,

Reinaldo C. Bazito

et al.

Measurement, Journal Year: 2024, Volume and Issue: 240, P. 115502 - 115502

Published: Aug. 11, 2024

Language: Английский

Citations

2
Optimization of drug solubility inside the supercritical CO2 system via numerical simulation based on artificial intelligence approach DOI Creative Commons

Meixiuli Li,

Wenyan Jiang, Shuang Zhao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 1, 2024

Language: Английский

Citations

1