Spontaneous behaviors drive multidimensional, brainwide activity

Science, Год журнала: 2019, Номер 364(6437)

Опубликована: Апрель 19, 2019

Neuron activity across the brain How is it that groups of neurons dispersed through interact to generate complex behaviors? Three papers in this issue present brain-scale studies neuronal and dynamics (see Perspective by Huk Hart). Allen et al. found thirsty mice, there widespread neural related stimuli elicit licking drinking. Individual encoded task-specific responses, but every area contained with different types response. Optogenetic stimulation thirst-sensing one reinstated drinking previously signaled thirst. Gründemann investigated mouse basal amygdala relation behavior during tasks. Two ensembles showed orthogonal exploratory nonexploratory behaviors, possibly reflecting levels anxiety experienced these areas. Stringer analyzed spontaneous firing, finding primary visual cortex both information motor facial movements. The variability responses mainly arousal reflects encoding latent behavioral states. Science , p. eaav3932 eaav8736 eaav7893 ; see also 236

Язык: Английский

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Breathing matters

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(6), С. 351 - 367

Опубликована: Май 8, 2018

Язык: Английский

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Movement-Related Signals in Sensory Areas: Roles in Natural Behavior

Trends in Neurosciences, Год журнала: 2020, Номер 43(8), С. 581 - 595

Опубликована: Июнь 22, 2020

Язык: Английский

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Neural circuits of social behaviors: Innate yet flexible

Neuron, Год журнала: 2021, Номер 109(10), С. 1600 - 1620

Опубликована: Март 11, 2021

Язык: Английский

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Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics

Nature Methods, Год журнала: 2024, Номер 21(7), С. 1329 - 1339

Опубликована: Июль 1, 2024

Abstract Keypoint tracking algorithms can flexibly quantify animal movement from videos obtained in a wide variety of settings. However, it remains unclear how to parse continuous keypoint data into discrete actions. This challenge is particularly acute because are susceptible high-frequency jitter that clustering mistake for transitions between Here we present keypoint-MoSeq, machine learning-based platform identifying behavioral modules (‘syllables’) without human supervision. Keypoint-MoSeq uses generative model distinguish noise behavior, enabling identify syllables whose boundaries correspond natural sub-second discontinuities pose dynamics. outperforms commonly used alternative methods at these transitions, capturing correlations neural activity and behavior classifying either solitary or social behaviors accordance with annotations. also works multiple species generalizes beyond the syllable timescale, fast sniff-aligned movements mice spectrum oscillatory fruit flies. Keypoint-MoSeq, therefore, renders accessible modular structure through standard video recordings.

Язык: Английский

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Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds

Neuron, Год журнала: 2020, Номер 107(5), С. 782 - 804

Опубликована: Авг. 12, 2020

Язык: Английский

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Breathing is coupled with voluntary action and the cortical readiness potential

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Фев. 6, 2020

Abstract Voluntary action is a fundamental element of self-consciousness. The readiness potential (RP), slow drift neural activity preceding self-initiated movement, has been suggested to reflect processes underlying the preparation voluntary action; yet more than fifty years after its introduction, interpretation RP remains controversial. Based on previous research showing that internal bodily signals affect sensory processing and ongoing activity, we here investigated role interoceptive in RP. We report (1) participants initiate actions frequently during expiration, (2) this respiration-action coupling absent externally triggered actions, (3) amplitude modulated depending respiratory phase. Our findings demonstrate coupled with system further suggest associated fluctuations are driven by involuntary cyclic motor act breathing.

Язык: Английский

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Circuits in the Rodent Brainstem that Control Whisking in Concert with Other Orofacial Motor Actions

Neuroscience, Год журнала: 2017, Номер 368, С. 152 - 170

Опубликована: Авг. 23, 2017

Язык: Английский

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Control of Orienting Movements and Locomotion by Projection-Defined Subsets of Brainstem V2a Neurons

Current Biology, Год журнала: 2020, Номер 30(23), С. 4665 - 4681.e6

Опубликована: Окт. 1, 2020

Spatial orientation requires the execution of lateralized movements and a change in animal's heading response to multiple sensory modalities. While much research has focused on circuits for integration, chiefly midbrain superior colliculus (SC), downstream cells that engage adequate motor actions have remained elusive. Furthermore, mechanisms supporting trajectory changes are still speculative. Here, using transneuronal viral tracings mice, we show brainstem V2a neurons, genetically defined subtype glutamatergic neurons reticular formation, receive putative synaptic inputs from contralateral SC. This makes them candidate relay orienting commands. We next unilateral optogenetic activations vivo evoked ipsilateral orienting-like responses head nose tip stationary mice. When animals walking, similar stimulations impose transient locomotor arrest followed by trajectory. Third, reveal these distinct controlled dedicated subsets each projecting specific spinal cord segment, with at least (1) lumbar-projecting subset whose activation specifically controls speed but neither impacts nor evokes movements, (2) cervical-projecting orientation, not speed. Activating latter suffices steer animals' directional heading, placing as prime driver their modular organization may therefore underlie orchestration during multi-faceted behaviors.

Язык: Английский

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Sniff-synchronized, gradient-guided olfactory search by freely moving mice

eLife, Год журнала: 2021, Номер 10

Опубликована: Май 4, 2021

For many organisms, searching for relevant targets such as food or mates entails active, strategic sampling of the environment. Finding odorous may be most ancient search problem that motile organisms evolved to solve. While chemosensory navigation has been well characterized in microorganisms and invertebrates, spatial olfaction vertebrates is poorly understood. We have established an olfactory assay which freely moving mice navigate noisy concentration gradients airborne odor. Mice solve this task using gradient cues do not require stereo performance. During performance, respiration nose movement are synchronized with tens milliseconds precision. This synchrony present during trials largely absent inter-trial intervals, suggesting sniff-synchronized a behavioral state rather than simply constant accompaniment fast breathing. To reveal spatiotemporal structure these active sensing movements, we used machine learning methods parse motion trajectories into elementary motifs. Motifs fall two clusters, correspond investigation approach states. Investigation motifs lock precisely sniffing, individual preferentially occur at specific phases sniff cycle. The allocentric indicates advantage both sides sharpest part odor gradient, consistent serial-sniff strategy sensing. work clarifies sensorimotor strategies mouse guides ongoing underlying neural mechanisms.

Язык: Английский

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