Dimensions of Early-Life Adversity Are Differentially Associated With Patterns of Delayed and Accelerated Brain Maturation

Biological Psychiatry, Год журнала: 2024, Номер 97(1), С. 64 - 72

Опубликована: Июль 29, 2024

BackgroundDifferent types of early-life adversity have been associated with children's brain structure and function. However, understanding the disparate influence distinct exposures on developing remains a major challenge.MethodsThis study investigates neural correlates 10 robust dimensions identified through exploratory factor analysis in large community sample youth from Adolescent Brain Cognitive Development (ABCD) Study. age models were trained, validated, tested separately T1-weighted (T1; N = 9524), diffusion tensor (DTI; 8834), resting-state functional (rs-fMRI; 8233) magnetic resonance imaging (MRI) data two time points (mean 10.7 years, SD 1.2, range 8.9-13.8 years).ResultsBayesian multilevel modelling supported associations between different younger- older-looking brains. Dimensions generally related to emotional neglect, such as lack primary secondary caregiver support, supervision, lower gaps (BAGs), i.e., younger-looking In contrast, psychopathology, trauma exposure, family aggression, substance use separation biological parent, socio-economic disadvantage neighbourhood safety higher BAGs, brains.ConclusionsThe findings suggest that are differentially neurodevelopmental patterns, indicative dimension-specific delayed accelerated maturation.

Язык: Английский

---

Puberty differentially predicts brain maturation in male and female youth: A longitudinal ABCD Study

Developmental Cognitive Neuroscience, Год журнала: 2023, Номер 61, С. 101261 - 101261

Опубликована: Июнь 1, 2023

Research has demonstrated associations between pubertal development and brain maturation. However, existing studies have been limited by small samples, cross-sectional designs, inconclusive findings regarding directionality of effects sex differences. We examined the longitudinal temporal coupling puberty status assessed using Pubertal Development Scale (PDS) magnetic resonance imaging (MRI)-based grey white matter structure. Our sample consisted 8896 children adolescents at baseline (mean age = 9.9) 6099 follow-up 11.9) from Adolescent Brain Cognitive (ABCD) Study cohort. Applying multigroup Bivariate Latent Change Score (BLCS) models, we found that PDS predicted rate change in cortical thickness among females surface area for both males females. also a correlation co-occurring changes over time males. Diffusion tensor (DTI) analyses revealed correlated fractional anisotropy (FA) females, but no significant mean diffusivity (MD). results suggest predicts maturation, strength differ sex. Further research spanning entire duration is needed to understand extent contribution on youth brain.

Язык: Английский

---

Differences in educational opportunity predict white matter development

Developmental Cognitive Neuroscience, Год журнала: 2024, Номер 67, С. 101386 - 101386

Опубликована: Апрель 22, 2024

Coarse measures of socioeconomic status, such as parental income or education, have been linked to differences in white matter development. However, these do not provide insight into specific aspects an individual's environment and how they relate brain On the other hand, educational intervention studies shown that changes context can drive measurable their matter. These studies, however, rarely consider factors results. In present study, we examined unique relationship between opportunity development, when controlling known factors. To explore this question, leveraged rich demographic neuroimaging data available ABCD well data-crosswalk Stanford Education Data Archive (SEDA). We find is related accelerated even accounting for factors, most pronounced tracts associated with academic skills. results suggest school a child attends has development years come.

Язык: Английский

---

The role of pubertal development in the association between trauma and internalising symptoms in female youth

Journal of Child Psychology and Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Background Exposure to trauma in childhood is associated with an increased risk for internalising symptoms. Alterations pubertal development has been proposed as a potential mechanism underpinning this association. However, longitudinal studies, which are needed examine over time, scarce. The goal of pre‐registered study was how exposure shapes the timing and tempo development, turn contributes symptoms female youth. Methods Using largest sample date, we characterised profiles across four time points youth from Adolescent Brain Cognitive Development (ABCD) Study ( N = 4,225, age range 9–14 years) using latent profile analysis. Pubertal assessed Scale (at points). Trauma quantified post‐traumatic stress disorder subscale parent‐report Kiddie Schedule Affective Disorders Schizophrenia DSM‐5 baseline), were self‐report Brief Problem Monitor 3‐year follow‐up). Results could be grouped into three classes: early starters (9% sample), typical developers (76%) slow (15%). demonstrated higher levels compared developers, while showed least trauma. Youth greater at ages 12–14 years, association mediated by status 9–10 but not faster tempo. Conclusions Accelerated earlier onset transition late adolescence, may through increases

Язык: Английский

---

The role of brain structure in the association between pubertal timing and depression risk in an early adolescent sample (the ABCD Study®): A registered report

Developmental Cognitive Neuroscience, Год журнала: 2023, Номер 60, С. 101223 - 101223

Опубликована: Фев. 25, 2023

Earlier pubertal timing is associated with higher rates of depressive disorders in adolescence. Neuroimaging studies report brain structural associations both and depression. However, whether structure mediates the relationship between depression remains unclear. The current registered examined (indexed via perceived development), (cortical subcortical metrics, white matter microstructure) symptoms a large sample (N = ∼5000) adolescents (aged 9–13 years) from Adolescent Brain Cognitive Development (ABCD) Study. We used three waves follow-up data when youth were aged 10–11 years, 11–12 12–13 respectively. generalised linear-mixed models (H1) equation modelling (H2 & H3) to test our hypotheses. hypothesised that earlier at Year 1 would be increased 3 (H1), this mediated by global (H2a-b) regional (H3a-g) measures 2. Global included reduced cortical volume, thickness, surface area sulcal depth. Regional thickness volume temporal fronto-parietal areas, ventral diencephalon, depth pars orbitalis, fractional anisotropy cortico-striatal tract corpus callosum. These regions interest informed pilot analyses using baseline ABCD 9–10 years. was two years later. magnitude effect stronger female association remained significant controlling for parental depression, family income, BMI females but not male youth. Our did however mediate later symptoms. present results demonstrate youth, particularly females, who begin puberty ahead their peers are an risk adolescent-onset Future work should explore additional biological socio-environmental factors may affect so we can identify targets intervention help these at-risk

Язык: Английский

---

Deviations from normative brain white and gray matter structure are associated with psychopathology in youth

Developmental Cognitive Neuroscience, Год журнала: 2022, Номер 58, С. 101173 - 101173

Опубликована: Ноя. 1, 2022

Combining imaging modalities and metrics that are sensitive to various aspects of brain structure maturation may help identify individuals show deviations in relation same-aged peers, thus benefit early-risk-assessment for mental disorders. We used one timepoint multimodal imaging, cognitive, questionnaire data from 1280 eight- twenty-one-year-olds the Philadelphia Neurodevelopmental Cohort. estimated age-related gray white matter properties individual deviation scores using normative modeling. Next, we tested associations between scores, with psychopathology domain cognition. More negative DTI-based fractional anisotropy (FA) first principal eigenvalue diffusion tensor (L1) were associated higher on psychosis positive prodromal symptoms general psychopathology. A more cortical thickness (CT) was a score. Negative global FA, surface area, L1 CT also poorer cognitive performance. No robust found based DTI. The low correlations different magnetic resonance imaging-based suggest psychopathological burden adolescence can be mapped onto partly distinct neurobiological features.

Язык: Английский

---

Brain Age Gap in Early Illness Schizophrenia and the Clinical High-Risk Syndrome: Associations With Experiential Negative Symptoms and Conversion to Psychosis

Schizophrenia Bulletin, Год журнала: 2024, Номер 50(5), С. 1159 - 1170

Опубликована: Май 30, 2024

Abstract Background and Hypothesis Brain development/aging is not uniform across individuals, spawning efforts to characterize brain age from a biological perspective model the effects of disease maladaptive life processes on brain. The gap represents discrepancy between estimated chronological (in this case, based structural magnetic resonance imaging, MRI). Structural MRI studies report an increased (biological > age) in schizophrenia, with greater related negative symptom severity. Less known regarding nature early schizophrenia (ESZ), if psychosis conversion biomarker clinical high-risk (CHR-P) how altered development and/or aging map onto specific facets. Study Design Using MRI, we compared among CHR-P (n = 51), ESZ 78), unaffected comparison participants (UCP; n 90), examined associations (CHR-P converters 10; non-converters; 23) positive symptoms. Results showed relative UCP (Ps < .010). individuals who converted (P .043) non-converters. A larger was associated experiential .008), but expressive Conclusions Consistent pathophysiological models positing abnormal maturation, results suggest present psychosis. An may be especially relevant motivational functional deficits schizophrenia.

Язык: Английский

---

The connecting brain in context: How adolescent plasticity supports experiential learning and development

Developmental Cognitive Neuroscience, Год журнала: 2024, Номер 71, С. 101486 - 101486

Опубликована: Ноя. 28, 2024

Язык: Английский

---

Functional brain network dynamics mediate the relationship between female reproductive aging and interpersonal adversity

Nature Mental Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, brain dynamics underlying this relationship are poorly understood. Here, address issue, we analyzed multimodal data from female participants in Adolescent Brain Cognitive Development (longitudinal, N = 441; aged 9–12 years) Human Connectome-Aging (cross-sectional, 130; 36–60 studies. Age-specific intrinsic functional network mediated link between perceptions of greater interpersonal adversity. The adolescent profile overlapped areas glutamatergic dopaminergic receptor density, middle-aged was concentrated visual, attentional default mode networks. two profiles showed opposite relationships with patterns neural variability cortical atrophy observed psychosis versus major depressive disorder. Our findings underscore divergent maturation senescence, which may explain developmentally specific vulnerabilities distinct disorders.

Язык: Английский

---

Assessing neurocognitive maturation in early adolescence based on baby and adult functional brain landscapes

Developmental Cognitive Neuroscience, Год журнала: 2025, Номер 73, С. 101543 - 101543

Опубликована: Март 6, 2025

Adolescence is a period of growth in cognitive performance and functioning. Recently, data-driven measures brain-age gap, which can index decline older populations, have been utilized adolescent data with mixed findings. Instead using approach, here we assess the maturation status brain functional landscape early adolescence by directly comparing an individual's resting-state connectivity (rsFC) to canonical early-life adulthood communities. Specifically, hypothesized that degree youth's connectome better captured adult networks compared infant/toddler predictive their development. To test this hypothesis across individuals longitudinally, Adolescent Brain Cognitive Development (ABCD) Study at baseline (9-10 years; n = 6469) 2-year-follow-up (Y2: 11-12 5060). Adjusted for demographic factors, our anchored rsFC score (AFC) was associated task both within participants. AFC related age aging youth, change statistically mediated age-related performance. In conclusion, showed model-fitting-free rest baby landscapes predicts development youth.

Язык: Английский

---