The
immunotherapy
targeting
tumor
immune
escape
mechanisms
has
become
a
critical
strategy
in
anticancer
treatment;
however,
the
challenge
of
resistance
remains
significant.
Autophagy,
cellular
response
to
various
stressors,
involves
degradation
damaged
proteins
and
organelles
via
lysosomal
pathways,
maintaining
homeostasis.
This
process
not
only
supports
cell
survival
but
also
profoundly
impacts
efficacy
cancer
immunotherapies.
modulation
autophagy
cells
or
exerts
dual
effects
on
immunotherapy.
However,
mechanistic
details
how
influences
system
therapy
remain
inadequately
understood.
Given
this
complexity,
deeper
understanding
role
tumor-immune
landscape
could
reveal
novel
therapeutic
avenues.
By
manipulating
appropriately,
it
may
be
possible
overcome
enhance
effectiveness
immunotherapeutic
strategies.
article
summarizes
immunity,
its
relationship
with
immunotherapy,
potential
benefits
strengthen
antitumor
responses
optimize
outcomes
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 10, 2024
Abstract
Human
microorganisms,
including
bacteria,
fungi,
and
viruses,
play
key
roles
in
several
physiological
pathological
processes.
Some
studies
discovered
that
tumour
tissues
once
considered
sterile
actually
host
a
variety
of
which
have
been
confirmed
to
be
closely
related
oncogenesis.
The
concept
intratumoural
microbiota
was
subsequently
proposed.
Microbiota
could
colonise
through
mucosal
destruction,
adjacent
tissue
migration,
hematogenic
invasion
affect
the
biological
behaviour
tumours
as
an
important
part
microenvironment.
Mechanistic
demonstrated
potentially
promote
initiation
progression
by
inducing
genomic
instability
mutations,
affecting
epigenetic
modifications,
promoting
inflammation
response,
avoiding
immune
regulating
metabolism,
activating
metastasis.
Since
more
comprehensive
profound
insights
about
intratumoral
are
continuously
emerging,
new
methods
for
early
diagnosis
prognostic
assessment
cancer
patients
under
examination.
In
addition,
interventions
based
on
show
great
potential
open
chapter
antitumour
therapy,
especially
immunotherapy,
although
there
some
inevitable
challenges.
Here,
we
aim
provide
extensive
review
concept,
development
history,
sources,
heterogeneity,
carcinogenic
mechanisms
explore
role
microorganisms
prognosis,
discuss
current
treatment
regimens
target
research
prospects
limitations
this
field.
Trends in Microbiology,
Год журнала:
2024,
Номер
32(8), С. 807 - 822
Опубликована: Фев. 3, 2024
The
microbiota
of
solid
tumors
was
identified
>100
years
ago;
however,
heterogeneous
composition
and
diversity
have
been
revealed
only
recently.
Growing
evidence
has
suggested
that
several
functional
mechanisms
the
intratumoral
affect
tumorigenesis
progression,
suggesting
is
a
promising
biomarker
for
multiple
cancers.
low
biomass
poses
major
challenge
to
related
research,
thus
necessitating
use
multiple-modality
integrated
framework
resolve
this
dilemma.
Advanced
techniques
such
as
single-cell
sequencing
provide
significant
clues,
gradual
optimization
experiments
culture-based
methods
enables
deeper
investigation
underlying
involved.
In
review,
we
outline
current
state
research
on
describe
challenges
comprehensive
strategies
future
research.
Pathogens,
Год журнала:
2024,
Номер
13(1), С. 93 - 93
Опубликована: Янв. 20, 2024
Epidemiological
studies
have
spotlighted
the
intricate
relationship
between
individual
oral
bacteria
and
tumor
occurrence.
Porphyromonas
gingivalis
Fusobacteria
nucleatum,
which
are
known
periodontal
pathogens,
emerged
as
extensively
studied
participants
with
potential
pathogenic
abilities
in
carcinogenesis.
However,
complex
dynamics
arising
from
interactions
these
two
pathogens
were
less
addressed.
This
narrative
review
aims
to
summarize
current
knowledge
on
prevalence
mechanism
implications
of
P.
F.
nucleatum
carcinogenesis
squamous
cell
carcinoma
(OSCC),
colorectal
cancer
(CRC),
pancreatic
ductal
adenocarcinoma
(PDAC).
In
particular,
it
explores
clinical
experimental
evidence
interplay
affecting
gastrointestinal
recognized
keystone
or
bridging
bacteria,
identified
multiple
simultaneously.
The
both
species
correlated
development
progression,
emphasizing
impact
collaboration.
Regrettably,
there
was
insufficient
demonstrate
synergistic
function.
We
further
propose
a
hypothesis
elucidate
underlying
mechanisms,
offering
promising
avenue
for
future
research
this
dynamic
evolving
field.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(4)
Опубликована: Апрель 18, 2024
Abstract
Dysbiosis
of
the
oral
microbiota
is
related
to
chronic
inflammation
and
carcinogenesis.
Fusobacterium
nucleatum
(
Fn
),
a
significant
component
microbiota,
can
perturb
immune
system
form
an
inflammatory
microenvironment
for
promoting
occurrence
progression
squamous
cell
carcinoma
(OSCC).
However,
underlying
mechanisms
remain
elusive.
Here,
we
investigated
impacts
on
OSCC
cells
crosstalk
between
macrophages.
16
s
rDNA
sequencing
fluorescence
in
situ
hybridization
verified
that
was
notably
enriched
clinical
tissues
compared
paracancerous
tissues.
The
conditioned
medium
co-culture
model
validated
macrophages
exhibited
tumor-promoting
properties
by
facilitating
proliferation,
migration,
invasion.
Besides,
recruit
facilitate
their
M2
polarization.
This
further
enhanced
,
thereby
amplifying
this
positive
feedback
loop
them.
production
CXCL2
response
stimulation
mediator.
Suppression
weakened
’s
effects
macrophage
recruitment,
Conversely,
knocking
down
reversed
-induced
effect
highly
invasive
phenotype
cells.
Mechanistically,
activated
NF-κB
pathway
both
macrophages,
leading
upregulation
expression.
In
addition,
SCC7
subcutaneous
tumor-bearing
C3H
mice
also
substantiated
ability
enhance
tumor
activating
signaling,
up-regulating
expression,
inducing
infiltration.
these
were
CXCL2-CXCR2
inhibitor
SB225002.
summary,
study
suggests
contributes
Simultaneously,
CXCL2-mediated
plays
vital
role
pro-cancer
.
Periodontology 2000,
Год журнала:
2024,
Номер
96(1), С. 112 - 149
Опубликована: Июль 4, 2024
Abstract
Increasing
evidence
suggests
a
significant
association
between
periodontal
disease
and
the
occurrence
of
various
cancers.
The
carcinogenic
potential
several
pathogens
has
been
substantiated
in
vitro
vivo.
This
review
provides
comprehensive
overview
diverse
mechanisms
employed
by
different
development
cancer.
These
induce
chronic
inflammation,
inhibit
host's
immune
system,
activate
cell
invasion
proliferation,
possess
anti‐apoptotic
activity,
produce
substances.
Elucidating
these
might
provide
new
insights
for
developing
novel
approaches
tumor
prevention,
therapeutic
purposes,
survival
improvement.
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Cancer
cells
exhibit
an
accelerated
glucose
uptake
and
glycolysis.
The
transmembrane
of
requires
specific
carrier
proteins,
such
as
transporters
(GLUTs)
sodium-coupled
cotransporters
(SGLTs).
GLUTs
transport
independently
the
energy
supply
have
become
promising
targets
for
cancer
therapy.
This
Perspective
mainly
focuses
on
current
research
progress
design
strategy
GLUT
inhibitors,
particularly
those
targeting
class
I
(GLUT1–4).
To
best
our
knowledge,
this
is
first
systematic
interpretation
progress,
opportunities,
challenges
faced
in
development
inhibitors
from
a
medicinal
chemistry
perspective.
We
hope
that
will
provide
insights
into
offering
feasible
approach
to
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 14, 2025
Macrophages
are
crucial
immune
cells
within
the
tumor
microenvironment
(TME),
involved
in
regulating
proliferation,
invasion,
metastasis,
ECM
remodeling,
angiogenesis,
and
immunosuppression.
Although
more
experimental
evidence
clinical
data
indicate
that
macrophages
onset
progression
of
oral
squamous
cell
carcinoma
(OSCC),
exact
pathogenesis
OSCC
associated
with
has
not
been
fully
elucidated.
Enhanced
knowledge
molecular
mechanisms
involving
will
aid
creation
treatments
targeted
specifically
at
macrophages.
This
review
outlines
pro-tumoral
anti-tumoral
effects
OSCC,
emphasizing
interaction
between
It
can
provide
theoretical
basis
for
establishment
complex
regulatory
network
centered
on
explore
novel
therapeutic
strategies
OSCC.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 7, 2025
Parvimonas
micra
(P.
micra),
an
opportunistic
oral
pathogen
associated
with
multiple
cancers,
has
limited
research
on
its
role
in
squamous
cell
carcinoma
(OSCC).
This
study
shows
that
P.
is
enriched
OSCC
tissues
and
positively
correlated
tumor
metastasis
stages.
infection
promotes
by
inducing
hypoxia/HIF-1α,
glycolysis,
autophagy.
Mechanistically,
surface
protein
TmpC
binds
to
CKAP4,
a
receptor
overexpressed
OSCC,
facilitating
bacterial
attachment
invasion.
interaction
activates
HIF-1α
autophagy
via
CKAP4-RanBP2
CKAP4-NBR1
pathways,
driving
metastasis.
Targeting
CKAP4
masitinib
or
antibodies
impairs
abolishes
micra-promoted
vitro
vivo.
Together,
our
findings
identify
as
highlight
TmpC-CKAP4
could
be
potential
therapeutic
target
for
OSCC.
micra)
frequently
present
lesions
infections.
Here,
authors
report
regulation
HIF-1α-induced
glycolysis
following
binding
receptor.
Advanced Materials,
Год журнала:
2024,
Номер
36(38)
Опубликована: Июль 26, 2024
Abstract
In
recent
years,
advancements
in
microbial
sequencing
technology
have
sparked
an
increasing
interest
the
bacteria
residing
within
solid
tumors
and
its
distribution
functions
various
tumors.
Intratumoral
critically
modulate
tumor
oncogenesis
development
through
DNA
damage
induction,
chronic
inflammation,
epigenetic
alterations,
metabolic
immune
regulation,
while
also
influencing
cancer
treatment
efficacy
by
affecting
drug
metabolism.
response
to
these
discoveries,
a
variety
of
anti‐cancer
therapies
targeting
microorganisms
emerged.
These
approaches
encompass
oncolytic
therapy
utilizing
tumor‐associated
bacteria,
design
biomaterials
based
on
intratumoral
use
bacterial
components
for
delivery
systems,
comprehensive
strategies
aimed
at
eradication
tumor‐promoting
bacteria.
Herein,
this
review
article
summarizes
patterns
different
tumors,
examines
their
impact
evaluates
current
therapeutic
centered
Furthermore,
challenges
prospects
developing
drugs
that
target
communities
are
explored,
promising
new
directions
treatment.
iScience,
Год журнала:
2024,
Номер
27(9), С. 110710 - 110710
Опубликована: Авг. 13, 2024
Mitochondria
play
important
roles
in
cell
fate,
calcium
signaling,
mitophagy,
and
the
signaling
through
reactive
oxygen
species
(ROS).
Recently,
mitochondria
are
considered
as
a
organelle
communicate
with
other
organelles
to
constitute
mitochondrial
information
processing
system
(MIPS)
that
transduce
input-to-output
biological
information.
The
success
immunotherapy,
concept
of
systemic
therapy,
has
been
proved
be
dependent
on
paracrine
interactions
within
tumor
microenvironment
(TME)
distant
organs
including
microbiota
immune
components.
We
will
adopt
broader
view
from
TME
micro-
macroenvironment
(T
