Foods,
Год журнала:
2024,
Номер
13(23), С. 3810 - 3810
Опубликована: Ноя. 26, 2024
Fumonisin
B1
is
a
common
food
contaminant
that
has
been
found
to
adversely
affect
the
reproductive
system,
especially
Sertoli
cells.
However,
potential
mitigation
of
FB1-induced
cytotoxicity
in
cells
not
fully
elaborated.
Resveratrol
natural
substance
with
anti-inflammatory,
antioxidant,
and
anti-tumor
properties.
Herein,
protective
effects
resveratrol
against
were
examined
this
work.
The
mouse
cell
line
(TM4)
was
used
as
research
model.
These
results
indicated
FB1
(40
μM
80
μM)
significantly
reduces
viability,
disrupts
barrier,
induces
an
inflammatory
response
TM4
To
our
surprise,
(15
showed
ability
reverse
adverse
induced
by
μM).
Furthermore,
could
alleviate
apoptosis,
decrease
ROS
level,
promote
antioxidant
enzymes
(CAT
SOD2)
expression
FB1-treated
addition
mitigate
promoted
phosphorylation
JNK
upregulation
c-jun
expression.
Interestingly,
also
able
FB2
μM),
FB3
FB1-FB2-FB3
μM-40
combination
group
on
In
summary,
displayed
may
fumonisin
B1-induced
via
inhibiting
oxidative
stress-mediated
JNK/c-jun
signaling
pathway-induced
apoptosis.
This
study
provides
new
insights
into
prevention
treatment
testicular
toxicity
highlights
application
value
resveratrol.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(7), С. 3314 - 3324
Опубликована: Фев. 8, 2024
Fusarium
species
produce
a
secondary
metabolite
known
as
T-2
toxin,
which
is
the
primary
and
most
harmful
toxin
found
in
type
A
trichothecenes.
widely
food
grain-based
animal
feed
endangers
health
of
both
humans
animals.
exposure
animals
occurs
primarily
through
administration;
therefore,
first
organ
that
targets
gut.
In
this
overview,
research
progress,
toxicity
mechanism,
detoxification
were
reviewed,
future
directions
proposed.
damages
intestinal
mucosa
destroys
structure
barrier
function;
furthermore,
disrupts
microbiota,
causes
flora
disorders,
affects
normal
metabolic
function,
kills
epidermal
cells
by
inducing
oxidative
stress,
inflammatory
responses,
apoptosis.
The
mechanism
intestine
stress.
Currently,
selenium
plant
extracts
are
mainly
used
to
exert
antioxidant
effects
alleviate
enterotoxicity
toxin.
studies,
use
genomic
techniques
find
upstream
signaling
molecules
associated
with
enterotoxin
will
provide
new
ideas
for
prevention
toxicity.
purpose
paper
review
progress
on
propose
treatment
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
T-2
toxin
is
a
highly
toxic
fungal
that
threatens
humans
and
animals'
health.
As
major
detoxifying
metabolic
organ,
the
kidney
also
target
of
toxin.
This
article
reviews
nephrotoxicity
research
progress,
covering
renal
structure
function
damage,
mechanisms,
detoxification
methods
to
future
directions.
damages
structure,
causing
dysfunction.
The
mechanism
involves
multiple
factors
including
oxidative
stress,
endoplasmic
reticulum
mitophagy,
inflammatory
responses,
apoptosis,
which
are
intertwined
interdependent.
Current
strategies
mainly
involve
reducing
in
feedstuff
using
antioxidant
substances,
but
both
have
limits.
Future
should
focus
on
cells
sensitivity
toxin,
exploring
key
molecules
toxin's
nephrotoxicity,
injury's
impact
other
organs,
better
methods.
review
aims
guide
underpin
toxin-induced
prevention
treatment.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116787 - 116787
Опубликована: Июль 26, 2024
T-2
toxin,
a
mycotoxin
found
in
foods
and
feeds,
poses
threat
to
female
reproductive
health
both
humans
animals.
LncRNA
CUFF.253988.1
(CUFF.253988.1),
highly
expressed
pigs,
has
an
undisclosed
regulatory
role.
This
study
aimed
establish
model
of
toxin-induced
ovarian
injury
sows,
vivo
vitro,
explore
the
role
potential
mechanisms
CUFF.253988.1.
The
results
showed
that
feeding
toxin-contaminated
feed
(1
mg/kg)
induced
follicle
atresia
mitochondrial
structural
damage,
accompanied
by
significant
upregulation
expression
ovaries.
Additionally,
toxin
inhibited
SIRT3/PGC1-α
pathway
associated
with
function.
Moreover,
cell
apoptosis
upregulating
Cyt
c,
Bax,
cleaved-caspase-9,
cleaved-caspase-3
proteins.
In
granulosa
AVG-16
cells
at
concentrations
10,
40
160
nM,
not
only
were
previously
mentioned
effects
observed,
but
also
decrease
membrane
potential,
ATP
content,
elevation
ROS
levels.
However,
downregulating
reversed
toxin's
inhibition
pathway,
alleviating
dysfunction
reducing
apoptosis.
Notably,
this
may
be
attributed
enrichment
mitochondria.
conclusion,
plays
pivotal
operating
through
promotion
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
269, С. 115743 - 115743
Опубликована: Ноя. 29, 2023
Deoxynivalenol
(DON)
is
the
most
common
mycotoxin
in
food
and
feed,
which
can
cause
undesirable
effects,
including
diarrhea,
emesis,
weight
loss,
growth
delay
livestock.
Intestinal
epithelial
cells
were
main
target
of
DON,
oxidative
stress
inflammatory
injury.
Tanshinone
IIA
(Tan
IIA)
fat-soluble
diterpene
quinone,
abundant
active
ingredient
salvia
miltiorrhiza
plant
with
antioxidant
anti-inflammatory
characteristics.
However,
it
not
clear
whether
Tan
protect
against
or
inhibit
intestinal
injury
under
DON
exposure.
This
study
aimed
to
explore
protective
effect
on
DON-induced
toxicity
porcine
jejunum
(IPEC-J2).
Cells
exposed
0,
0.5,
1.0,
2.0
µM
and/or
45
µg/mL
TAN
ⅡA
detect
indicators.
cytokines,
NF-κB
expression,
NLRP3
inflammasome
pyroptosis-related
factors.
In
this
study,
exposure
caused
IPEC-J2
by
elevating
ROS
8-OHdG
content,
inhibited
GSH-Px
activity.
Furthermore,
increased
pro-inflammatory
factor
(TNF-α,
IL-1β,
IL-18
IL-6)
expression
decreased
(IL-10)
causing
response
via
triggering
pathway.
Interestingly,
above
changes
alleviated
after
treatment.
addition,
relieved
pyroptosis
suppressing
factors
(NLRP3,
Caspase-1,
GSDMD,
IL-18).
general,
our
data
suggested
that
ameliorate
associated
signaling
Our
findings
pointed
could
be
used
as
potential
therapeutic
drugs
enterotoxicity.
Antioxidants,
Год журнала:
2024,
Номер
13(1), С. 121 - 121
Опубликована: Янв. 18, 2024
Deoxynivalenol
(DON)
is
the
one
of
most
common
mycotoxins,
widely
detected
in
various
original
foods
and
processed
foods.
Tanshinone
IIA
(Tan
IIA)
a
fat-soluble
diterpene
quinone
extracted
from
Salvia
miltiorrhiza
Bunge,
which
has
multi-biological
functions
pharmacological
effects.
However,
whether
Tan
protective
effect
against
DON-induced
intestinal
toxicity
unknown.
In
this
study,
results
showed
treatment
could
attenuate
IPEC-J2
cell
death.
DON
increased
oxidation
product
accumulation,
decreased
antioxidant
ability
disrupted
barrier
function,
while
reversed
function
impairment
oxidative
stress.
Furthermore,
dramatically
improved
mitochondrial
via
quality
control.
upregulate
biogenesis
fusion
as
well
downregulate
fission
unfolded
protein
response.
addition,
significantly
attenuated
mitophagy
caused
by
DON.
Collectively,
presented
potential
underlying
mechanisms
were
involved
control–mediated
mitophagy.
Environmental Toxicology,
Год журнала:
2023,
Номер
39(2), С. 905 - 914
Опубликована: Ноя. 13, 2023
Abstract
Fumonisins
are
common
contaminants
in
the
global
food
and
environment,
pose
a
variety
of
health
risks
to
humans
animals.
However,
method
mitigating
fumonisin
toxicity
is
still
unclear.
Resveratrol
natural
compound
with
antioxidant
anti‐inflammatory
properties.
In
this
study,
protective
effect
resveratrol
against
fumonisin‐induced
intestinal
was
investigated
by
porcine
epithelial
cell
line
(IPEC‐J2).
The
cells
were
treated
0–40
μM
for
24
or
48
h
without
(15
μM)
pretreatment.
data
showed
that
could
alleviate
B1
(FB1)‐induced
decrease
viability
amplify
membrane
permeability.
At
same
time,
it
reduce
accumulation
intracellular
reactive
oxygen
species
increase
expression
ranges
Nrf2
downstream
genes
(SOD1
NQO‐1),
thereby
counteracting
FB1‐induced
apoptosis.
Furthermore,
able
levels
inflammatory
factors
(TNF‐α,
IL‐1β,
IL‐6),
tight
junction
proteins
(Claudin‐1,
Occludin,
ZO‐1),
integrity
IPEC‐J2
monolayer.
Our
also
attenuate
co‐occurrence
three
fumonisins.
It
implied
represents
promising
approach
fumonisin,
even
other
mycotoxins
future.
This
provided
new
strategy
further
blocking
controlling
subsequently
avoiding
adverse
effects
on
human
animal
health.
