Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Phytotherapy Research, Год журнала: 2023, Номер 37(4), С. 1590 - 1605

Опубликована: Фев. 8, 2023

Abstract Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a polyphenol got from red wine peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', hinders destructive effects inflammatory causes oxygen radicals several tissues. The nuclear erythroid 2‐related factor 2 related to transcription with anti‐inflammatory, antioxidant possessions which complicated enzyme biotransformation biosynthesis carbohydrates. review provides current understanding information about character against stress regulation inflammation via Nrf2 signaling pathway.

Язык: Английский

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A Comprehensive Review of Free Radicals, Oxidative Stress, and Antioxidants: Overview, Clinical Applications, Global Perspectives, Future Directions, and Mechanisms of Antioxidant Activity of Flavonoid Compounds

Journal of Chemistry, Год журнала: 2024, Номер 2024, С. 1 - 21

Опубликована: Май 31, 2024

Absorption​ of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.

Язык: Английский

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A review on biochemical constituents of pumpkin and their role as pharma foods; a key strategy to improve health in post COVID 19 period

Food Production Processing and Nutrition, Год журнала: 2023, Номер 5(1)

Опубликована: Март 22, 2023

Abstract Progression of today’s world has been given setback due to the adversity a novel, viral, deadly outbreak COVID 19, which raised concerns scientists, researchers and health related officials about inherent adaptive immune system living body its relation with healthy diet balanced pharma foods. Now is coming out destructive pandemic era, choice right food can help build boost immunity pumpkin excellent profile functional nutraceutical constituents could be part both infected non-infected person’s daily diet. Vitamins like A, C E, minerals zinc, iron selenium, essential oils, peptides, carotenoids polysaccharides present in accommodate prevailing deficiencies fought against viral pathogens. In current post 19 scenario adequate supply diet, foods play basic role boosting populations. This review covers pharmacological activities pandemic. Pumpkins are well equipped nutraceuticals bioactives tocopherols, polyphenols, terpenoids lutein therefore, consumption processing this remarkable vegetable encouraged as antihyperlipidemic, antiviral, anti-inflammatory, antihyperglycemic, immunomodulatory, antihypertensive, antimicrobial antioxidant potential. Need eating period very crucial for population, medicinal vital developing community around globe. Graphical

Язык: Английский

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Oxidative Stress and Age-Related Tumors

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1109 - 1109

Опубликована: Сен. 13, 2024

Oxidative stress is the result of imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous exogenous processes, antioxidant defenses consisting molecules that protect biological systems from free radical toxicity. a major factor in aging process, contributing to accumulation cellular damage over time. biomolecules, leads DNA alterations, lipid peroxidation, protein oxidation, mitochondrial dysfunction resulting senescence, immune system tissue dysfunctions, increased susceptibility age-related pathologies, such as inflammatory disorders, cardiovascular neurodegenerative diseases, diabetes, cancer. stress-driven mutations, or methylation histone modification, alter gene expression, key determinants tumor initiation, angiogenesis, metastasis, therapy resistance. Accumulation genetic epigenetic damage, oxidative contributes, eventually unrestrained cell proliferation, inhibition differentiation, evasion death, providing favorable conditions for tumorigenesis. Colorectal, breast, lung, prostate, skin cancers most frequent aging-associated malignancies, implicated their pathogenesis behavior. Our aim shed light on molecular mechanisms link stress, aging, cancers, highlighting impact both RONS antioxidants, provided diet exercise, immunity, development an antitumor response. The dual role ROS physiological regulators signaling responsible well its use anti-tumor therapeutic purposes, will also be discussed. Managing crucial promoting healthy reducing risk tumors.

Язык: Английский

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Effect of Sustainable Pretreatments on the Nutritional and Functionality of Chickpea Protein: Implication for Innovative Food Product Development

Journal of Food Biochemistry, Год журнала: 2024, Номер 2024, С. 1 - 29

Опубликована: Фев. 7, 2024

Chickpea is a globally cultivated legume, rich in vitamins, protein, carbohydrates, polyphenols, fatty acids, fibers, and flavonoids. Despite its nutritional benefits, chickpeas contain antinutritional factors that can hinder nutrient absorption. Therefore, we reviewed the various pretreatment methods to enhance chickpea protein’s value functional properties. Thermal biochemical treatments food applications of protein are thoroughly reviewed. The review revealed physical, thermal, were reported be effective reducing improving solubility, emulsifying capacity, foaming proteins used cereals bakery products meet consumer demand. Encapsulation enhances stability, inclusion gluten-free has different effects on glycemic index, antioxidant activity, overall acceptability. These findings highlight chickpea’s potential improve aspects while offering health benefits consumers.

Язык: Английский

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Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Foods, Год журнала: 2022, Номер 11(18), С. 2884 - 2884

Опубликована: Сен. 17, 2022

The beginning of the end or beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. reduction severe cases and deaths from COVID-19 led to increasing importance new called post-COVID syndrome. term is used indicate permanency symptoms in patients who have recovered acute respiratory syndrome 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well ozone therapy been treat disease. Vaccines then become available administered worldwide prevent insurgence However, pandemic not over yet at all given emergence omicron variants. New therapeutic strategies urgently needed. In this view, great interest was found nutraceutical products, including vitamins (C, D, E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), curcumin. This review summarizes role nutraceuticals prevention and/or treatment

Язык: Английский

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Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

Biomolecules, Год журнала: 2023, Номер 13(11), С. 1600 - 1600

Опубликована: Окт. 31, 2023

Aging is a natural and inescapable phenomenon characterized by progressive deterioration of physiological functions, leading to increased vulnerability chronic diseases death. With economic medical development, the elderly population gradually increasing, which poses great burden society, economy field. Thus, healthy aging has now become common aspiration among people over world. Accumulating evidence indicates that substances can mediate deteriorated processes are highly likely have potential prolong lifespan improve aging-associated diseases. Foods from sources full bioactive compounds, such as polysaccharides, polyphenols, carotenoids, sterols, terpenoids vitamins. These compounds their derivatives been shown be able delay and/or diseases, thereby prolonging lifespan, via regulation various processes. Here, we summarize current understanding anti-aging activities vitamins food sources, modes action in delaying improving This will certainly provide reference for further research on effects sources.

Язык: Английский

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The Role of Glutathione in Selected Viral Diseases

Antioxidants, Год журнала: 2023, Номер 12(7), С. 1325 - 1325

Опубликована: Июнь 22, 2023

During inflammatory processes, immunocompetent cells are exposed to substantial amounts of free radicals and toxic compounds. Glutathione is a cysteine-containing tripeptide that an important ubiquitous antioxidant molecule produced in human organs. The intracellular content GSH regulates the detoxifying capacity cells, as well immune response. particularly liver, where it serves major non-protein thiol involved cellular defense. There numerous causes hepatitis. inflammation liver can be caused by variety infectious viruses. relationship between oxidative stress hepatitis A virus (HAV), B (HBV), C (HCV), E (HEV) infection not fully known. aim this study was examine hepatotropic viruses glutathione status, including reduced (GSH) oxidized (GSSG), enzymes, e.g., peroxidase (GPx), reductase (GR) glutathione-S-transferase (GST) diseases.

Язык: Английский

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Role of dietary supplements in the continuous battle against COVID‐19

Phytotherapy Research, Год журнала: 2024, Номер 38(2), С. 1071 - 1088

Опубликована: Янв. 2, 2024

Abstract A sudden outbreak of the COVID‐19 pandemic was a big blow to world community on every level. Created by novel coronavirus, SARS‐CoV‐2, which previously unknown human immune system. The expert opinion almost immediately united fact that most effective way fighting would be building immunity artificially via mass immunization program. However, it took about year for approval first vaccine against COVID‐19. In meantime, part general population started adapting nutritious diet plans and dietary supplements boost natural as potential prophylactic strategy SARS‐CoV‐2 infection. Whether they originate from mainstream medicine, such synthetic supplements, or traditional herbal remedies in form single poly‐herbs, these may comprise various components exhibit immunomodulatory, anti‐inflammatory, antioxidant, antimicrobial characteristics. There is substantial body predictions opinions suggesting enhancing one's with containing additional nutrients bioactive compounds like vitamins, minerals, amino acids, fatty phytochemicals, probiotics can enhance system's ability develop resistance COVID‐19, although none them have any conclusive evidence nor officially recommended World Health Organization (WHO). current review critically acclaims gap between public perception‐based preference real evidence‐based study weigh actual benefit relation prevention management.

Язык: Английский

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Molecular Mechanisms Related to Responses to Oxidative Stress and Antioxidative Therapies in COVID-19: A Systematic Review

Antioxidants, Год журнала: 2022, Номер 11(8), С. 1609 - 1609

Опубликована: Авг. 19, 2022

The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease's progression not entirely understood, but there are strong indications that oxidative stress defense against reactive oxygen species crucial players. A big influx of immune cells to site infection marked by increase in nitrogen species. Our article aims highlight critical role emergence severity COVID-19 and, more importantly, shed light on underlying molecular genetic mechanisms. We have reviewed available literature clinical trials extract relevant variants within pathway associated with anti-oxidative therapies currently evaluated for treatment, particular glutathione N-acetylcysteine.

Язык: Английский

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