Polymers,
Год журнала:
2023,
Номер
15(12), С. 2638 - 2638
Опубликована: Июнь 9, 2023
As
a
Food
and
Drug
Administration
(FDA)-approved
molecular-targeted
chemotherapeutic
drug,
sorafenib
(SF)
can
inhibit
angiogenesis
tumor
cell
proliferation,
leading
to
improved
patient
overall
survival
of
hepatocellular
carcinoma
(HCC).
In
addition,
SF
is
an
oral
multikinase
inhibitor
as
single-agent
therapy
in
renal
carcinoma.
However,
the
poor
aqueous
solubility,
low
bioavailability,
unfavorable
pharmacokinetic
properties
undesirable
side
effects
(anorexia,
gastrointestinal
bleeding,
severe
skin
toxicity,
etc.)
seriously
limit
its
clinical
application.
To
overcome
these
drawbacks,
entrapment
into
nanocarriers
by
nanoformulations
effective
strategy,
which
delivers
target
with
decreased
adverse
treatment
efficacy.
this
review,
significant
advances
design
strategies
nanodelivery
systems
from
2012
2023
are
summarized.
The
review
organized
type
carriers
including
natural
biomacromolecule
(lipid,
chitosan,
cyclodextrin,
etc.);
synthetic
polymer
(poly(lactic-co-glycolic
acid),
polyethyleneimine,
brush
copolymer,
mesoporous
silica;
gold
nanoparticles;
others.
Co-delivery
other
active
agents
(glypican-3,
hyaluronic
acid,
apolipoprotein
peptide,
folate,
superparamagnetic
iron
oxide
nanoparticles)
for
targeted
nanosystems
synergistic
drug
combinations
also
highlighted.
All
studies
showed
promising
results
HCC
cancers
SF-based
nanomedicines.
outlook,
challenges
future
opportunities
development
delivery
presented.
Nanoscale,
Год журнала:
2024,
Номер
16(9), С. 4434 - 4483
Опубликована: Янв. 1, 2024
Metal-organic
frameworks
have
become
promising
stimuli-responsive
agents
to
release
the
loaded
therapeutic
in
target
site
achieve
more
precise
drug
delivery
due
their
high
loading,
excellent
biocompatibility,
and
stimuli-responsiveness.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 6, 2023
Abstract
Nanobiotechnology,
as
a
novel
and
more
specialized
branch
of
science,
has
provided
number
nanostructures
such
nanoparticles,
by
utilizing
the
methods,
techniques,
protocols
other
branches
science.
Due
to
unique
features
physiobiological
characteristics,
these
or
nanocarriers
have
vast
methods
therapeutic
against
microbial
infections
cancers
for
tissue
regeneration,
engineering,
immunotherapies,
gene
therapies,
through
drug
delivery
systems.
However,
reduced
carrying
capacity,
abrupt
non-targeted
delivery,
solubility
agents,
can
affect
applications
biotechnological
products.
In
this
article,
we
explored
discussed
prominent
nanobiotechnological
products
nanocarriers,
highlighted
challenges
associated
with
products,
attempted
conclude
if
available
offer
any
scope
improvement
enhancement.
We
aimed
identify
emphasize
greater
prospect
capacity
improvements
enhancements.
found
that
nanostructures,
nanocomposites,
micelles,
hydrogels,
microneedles,
artificial
cells,
address
inherited
drawbacks,
help
conjugations,
sustained
stimuli-responsive
release,
ligand
binding,
targeted
delivery.
recommend
nanobiotechnology,
despite
having
few
offers
immense
opportunities
be
harnessed
in
delivering
quality
therapeutics
precision
prediction.
also
that,
exploring
branched
domains
rigorously,
bottlenecks
obstacles
addressed
resolved
return.
Graphical
Molecules,
Год журнала:
2023,
Номер
28(24), С. 8141 - 8141
Опубликована: Дек. 17, 2023
The
study
of
natural
products
as
potential
drug
leads
has
gained
tremendous
research
interest.
Quercetin
is
one
those
products.
It
belongs
to
the
family
flavonoids
and,
more
specifically,
flavonols.
This
review
summarizes
beneficial
pharmaceutical
effects
quercetin,
such
its
anti-cancer,
anti-inflammatory,
and
antimicrobial
properties,
which
are
some
quercetin
described
in
this
review.
Nevertheless,
shows
poor
bioavailability
low
solubility.
For
reason,
encapsulation
macromolecules
increases
therefore
efficiency.
In
review,
a
brief
description
different
forms
described,
new
ones
proposed.
applying
nanotechnology
outlined.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 6, 2023
Cancer
has
remained
one
of
the
leading
causes
death
worldwide,
with
a
lack
effective
treatment.
The
intrinsic
shortcomings
conventional
therapeutics
regarding
tumor
specificity
and
non-specific
toxicity
prompt
us
to
look
for
alternative
mitigate
these
limitations.
In
this
regard,
we
developed
multifunctional
bimetallic
(FeCo)
bi-MIL-88B-FC
MOFs
modified
folic
acid-conjugated
chitosan
(FC)
as
drug
delivery
systems
(DDS)
targeted
5-Fluorouracil
(5-FU).
bi-MIL-88B
nanocarriers
were
characterized
through
various
techniques,
including
powder
X-ray
diffraction,
scanning
electron
microscopy,
energy-dispersive
X-ray,
thermogravimetric
analysis,
Fourier
transform
infrared
spectroscopy.
Interestingly,
5-FU@bi-MIL-88B-FC
showed
slower
release
5-FU
due
gated
effect
phenomenon
endowed
by
FC
surface
coating
compared
un-modified
5-FU@bi-MIL-88B.
pH-responsive
was
observed,
58%
loaded
released
in
cancer
cells
mimicking
pH
(5.2)
only
24.9%
under
physiological
(5.4).
vitro
cytotoxicity
cellular
internalization
experiments
revealed
superiority
highly
potent
DDS
against
folate
receptor
(FR)
positive
SW480
cells.
Moreover,
presence
Fe
Co
structure,
exhibited
peroxidase-like
activity
chemodynamic
therapy.
Based
on
results,
could
serve
promising
candidate
smart
sustained
selective
targeting.
Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1566 - 1566
Опубликована: Май 22, 2023
The
paradigm
of
drug
delivery
via
particulate
formulations
is
one
the
leading
ideas
that
enable
overcoming
limitations
traditional
chemotherapeutic
agents.
trend
toward
more
complex
multifunctional
carriers
well-traced
in
literature.
Nowadays,
prospectiveness
stimuli-responsive
systems
capable
controlled
cargo
release
lesion
nidus
widely
accepted.
Both
endogenous
and
exogenous
stimuli
are
employed
for
this
purpose;
however,
pH
most
common
trigger.
Unfortunately,
scientists
encounter
multiple
challenges
on
way
to
implementation
idea
related
vehicles’
accumulation
off-target
tissues,
their
immunogenicity,
complexity
intracellular
targets,
finally,
difficulties
fabrication
matching
all
imposed
requirements.
Here,
we
discuss
fundamental
strategies
pH-responsive
delivery,
as
well
such
carriers’
application,
reveal
main
problems,
weaknesses,
reasons
poor
clinical
results.
Moreover,
attempted
formulate
profiles
an
“ideal”
carrier
frame
different
drawing
example
metal-comprising
materials
considered
recently
published
studies
through
lens
these
profiles.
We
believe
approach
will
facilitate
formulation
facing
researchers
identification
promising
trends
technology
development.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
492, С. 152295 - 152295
Опубликована: Май 16, 2024
The
relentless
advancement
of
cancer,
a
leading
cause
mortality
worldwide,
underscores
the
need
for
innovative
therapeutic
strategies.
Amorphous
metal–organic
frameworks
(aMOFs)
have
emerged
as
paradigm-shifting
solution
in
field
cancer
diagnostics
and
therapeutics,
distinguishing
themselves
from
their
crystalline
counterparts
through
superior
properties
functionalities.
This
comprehensive
review
explores
synthesis,
unique
properties,
multifaceted
applications
aMOFs
diagnosis
treatment.
Compared
with
counterparts,
display
including
enhanced
catalytic
performance,
exceptional
porosity,
elevated
thermal
conductivity.
These
underpin
extensive
use
sensitive
biochemical
detection
precision
drug
delivery,
tumor
ablation,
other
applications.
Their
inherent
chemical
tunability
further
enables
integration
multifunctional
anticancer
strategies,
ranging
multiple
biomedical
imaging
to
phototherapy
metal
ion-mediated
apoptosis,
positioning
versatile
theranostic
nanoplatforms.
article
delves
into
current
oncological
challenges
prospects
aMOFs,
underscoring
transformative
potential
advanced
diagnostics,
targeted
therapy,
development
next-generation
convergence
computational
simulations
interdisciplinary
research
is
anticipated
accelerate
clinical
translation
heralding
new
era
personalized
medicine.
