Advanced applications of smart electrospun nanofibers in cancer therapy: With insight into material capabilities and electrospinning parameters

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100265 - 100265

Опубликована: Июнь 26, 2024

Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.

Язык: Английский

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Nanomaterial surface modification toolkit: Principles, components, recipes, and applications

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 322, С. 103035 - 103035

Опубликована: Ноя. 3, 2023

Surface-functionalized nanostructures are at the forefront of biotechnology, providing new opportunities for biosensors, drug delivery, therapy, and bioimaging applications. The modification significantly impacts performance success various applications by enabling selective precise targeting. This review elucidates widely practiced surface strategies, including click chemistry, cross-coupling, silanization, aldehyde linkers, active ester maleimide epoxy other protein DNA-based methodologies. We also delve into application-focused landscape nano-bio interface, emphasizing four key domains: therapeutics, biosensing, environmental monitoring, point-of-care technologies, highlighting prominent studies. insights presented herein pave way further innovations intersection nanotechnology a useful handbook beginners professionals. draws on sources, latest research articles (2018-2023), to provide comprehensive overview field.

Язык: Английский

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Novel chitosan/γ-alumina/carbon quantum dot hydrogel nanocarrier for targeted drug delivery

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 251, С. 126280 - 126280

Опубликована: Авг. 15, 2023

Curcumin (CUR) is among the most natural and effective antitumor drugs for cancer treatment. These have low solubility short half-lives that reduce their effectiveness in drug release systems. Herein, a hydrogel nanocarrier containing chitosan (CS), alumina (γ-Al2O3), carbon quantum dots (CQDs) was prepared by water-in-oil-in-water (W/O/W) double nanoemulsion method. DLS revealed size of 227 nm, with zeta potential −37.8 mV, which corroborates its stability. FE-SEM showed quasi-spherical shape, FT-IR XRD confirmed presence all components nanocomposite gave information about intermolecular interactions between them crystalline nature nanocarrier, respectively. The loading (48 %) entrapment efficiency (86 were higher than those reported previously other CUR nanocarriers. profile controlled stable release, pH-sensitive behavior, faster an acid environment. breast cell line examined cytotoxicity apoptosis analyses. results slow over time programmed death due to nanocarrier. Considering obtained herein, CS/γAl2O3/CQDs/CUR can be considered as promising new nanosystem tumor

Язык: Английский

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Nanocomposite of chitosan/gelatin/carbon quantum dots as a biocompatible and efficient nanocarrier for improving the Curcumin delivery restrictions to treat brain cancer

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124986 - 124986

Опубликована: Май 24, 2023

Язык: Английский

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pH-sensitive polyacrylic acid /Fe3O4@SiO2 hydrogel nanocomposite modified with agarose for controlled release of quercetin

Inorganic Chemistry Communications, Год журнала: 2024, Номер 163, С. 112338 - 112338

Опубликована: Март 23, 2024

Cancer has consistently been a significant global concern as the leading second cause of death. Improving performance chemical methods using drug delivery system is an alternative approach to cancer treatment. In this study, anti-cancer drug, quercetin (QC), was investigated by placing it in pH-sensitive hydrogel nanocomposite made polyacrylic acid (PAA), agarose, and Fe3O4@SiO2 particles. Then, release control improved double emulsion method. Spherical nanoparticles with smooth surface morphology were observed images obtained through field-emission scanning electron microscopy (FESEM), their average size determined be 193 nm dynamic light scattering (DLS) method, they exhibited zeta potential 38 mV. Fourier transform infrared spectroscopy (FTIR) X-ray diffraction (XRD) analyses provided evidence interactions bonds structure. The magnetic properties nanocarrier studied vibrating-sample magnetometry (VSM). amount loaded PAA-Agarose/Fe3O4@SiO2 increased 86 %, while encapsulation efficiency 48 %. Drug kinetics at physiological (7.4) acidic (5.4) pH best fitted Korsmeyer-Peppas model, indicating non-Fickian diffusion mechanism. U-87 MG glioma cell line evaluated for toxicity cytotoxicity assay (MTT) flow cytometry. A higher percentage apoptosis found PAA-Agarose/Fe3O4@SiO2-QC compared free QC system. findings corroborate that developed herein highly effective pH-responsive treatment applications.

Язык: Английский

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A green approach for preparation of polyacrylic acid/starch incorporated with titanium dioxide nanocomposite as a biocompatible platform for curcumin delivery to breast cancer cells

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124785 - 124785

Опубликована: Май 9, 2023

Язык: Английский

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Chitosan-Carbon nanotube Composite: An approach for controlled release of Quercetin, Modified with carboxymethyl Cellulose, for potential Anti-Cancer therapy

Inorganic Chemistry Communications, Год журнала: 2023, Номер 158, С. 111621 - 111621

Опубликована: Окт. 27, 2023

Язык: Английский

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Hydroxyapatite modified poly(acrylic acid)/polyethylene glycol sustainable drug delivery nanocomposite prepared via double emulsion with bitter almond oil

Sustainable Chemistry and Pharmacy, Год журнала: 2024, Номер 38, С. 101497 - 101497

Опубликована: Фев. 21, 2024

A sustainable hydrogel-based drug delivery system for pH-sensitive of doxorubicin (DOX) as a model has been developed the first time to address some complications chemotherapy. The biobased nanocomposite comprising hydroxyapatite (HAP) nanoparticles loaded in biodegradable poly(acrylic acid) (PAA)/polyethylene glycol (PEG) hydrogel network was prepared via double emulsion method using bitter almond oil and span 80 surfactant. Double emulsions can expand release drugs longer period well increase their bioavailability tumor tissues. Multiple analyses were conducted assess structure nanocarriers therapeutic efficiency. XRD FTIR corroborated successful synthesis gave insight into crystalline nature molecular interactions between components. DLS revealed monodispersity nanocarriers, with an average size 418 nm. TEM SEM showed spherical porous morphology zeta potential measurements indicated surface charge −34.5 mV, thus corroborating excellent stability suitability long storage. loading entrapment efficiencies (46% 87.5%, respectively) higher than those reported previously similar nanocarriers. An effective sustained profile observed at pH 5.4. MMT assay flow cytometric that satisfactory cytotoxicity compared free DOX.

Язык: Английский

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Synthesis and characterization of biological macromolecules double emulsion based on carboxymethylcellulose/gelatin hydrogel incorporated with ZIF-8 as metal organic frameworks for sustained anti-cancer drug release

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 243, С. 125168 - 125168

Опубликована: Июнь 1, 2023

Язык: Английский

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Polyacrylic acid/polyvinylpyrrolidone/iron oxide nanocarrier for efficient delivery of doxorubicin

Inorganic Chemistry Communications, Год журнала: 2024, Номер 161, С. 112037 - 112037

Опубликована: Янв. 8, 2024

Recently, stimuli-responsive drug delivery systems (DDS), especially pH-responsive ones, have drawn a lot of attention to overcome the unfavourable side effects traditional cancer treatments. In this work, nanocomposite hydrogel based on polyacrylic acid (PAA), polyvinylpyrrolidone (PVP), and iron oxide (hematite, Fe2O3) nanoparticles was developed using water/oil/water emulsification technique for efficient doxorubicin (DOX) drug. The synthesized nanocarrier characterized via XRD, FT-IR get information about its crystalline structure interaction between functional groups different constituents, respectively. Its size distribution colloidal stability were investigated DLS zeta potential tests, morphological study carried out by FE-SEM. found be uniform monodisperse, with an average 319 nm surface charge −30.4 mV. incorporation hematite increased loading (48.5 %) encapsulation efficiency (86.57 due high porosity area. Drug release tested at pH 7.4 5.4, corresponding healthy cancerous tissues, results demonstrated responsiveness system, faster (54 % in 24 h) medium. MTT flow cytometry tests corroborated strong anticancer effect since nano-platform significantly reduced survival rate cells. designed platform holds great breast therapy.

Язык: Английский

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