Vascular Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Introduction:
Exercise
transcutaneous
oximetry
(Ex-TcpO2)
is
used
to
support
the
vascular
origin
of
lower-limb
pain,
or
assess
walking
impairment.
The
aim
this
study
was
describe
association
between
Ex-TcpO2
measurement
and
perioperative
clinical
morphological
outcomes
after
revascularization
in
patients
with
intermittent
claudication
(IC).
Methods:
From
January
December
2022,
a
single-center
prospective
observational
conducted
among
IC.
Patients
were
referred
by
surgeons
for
doubtful
arterial
origin.
Perioperative
assessed
Rutherford–Becker
classification
duplex
ultrasound
examination.
primary
patency
rate
sustained
improvement
evaluated
at
1
month
revascularization.
Results:
Eighty-two
(64%
men)
underwent
enrolled
study,
whom
65%
category
III
Rutherford
classification.
Indications
IC
symptoms
65%.
Sixty-seven
(81%)
had
positive
Ex-TcpO2,
15
(18%)
negative
Ex-TcpO2.
older
(65
±
13
vs
58
20,
p
=
0.43),
significantly
lower
ankle–brachial
index
(ABI)
compared
group
(0.65
0.22
0.92
0.22,
<
0.001)
as
well
maximum
distance
(MWD)
(200
m
[150,
300]
525
[500,
872],
0.001).
Forty-two
(Ex-TcpO2
[
n
35/67];
7/15]).
Revascularization
technical
success
100%
both
groups.
Clinical
greater
(97%
34/35]
0%
0/7],
Multivariate
analysis
shows
pain
buttock
decrease
from
rest
oxygen
pressure
(DROP)
≤
–15
mmHg
level
presence
iliac
lesions.
Conclusion:
On
routine
basis,
tool
interest
distance,
especially
proximal
IC,
predict
favorable
Diabetes Therapy,
Год журнала:
2024,
Номер
15(9), С. 1893 - 1961
Опубликована: Июль 18, 2024
Type
2
diabetes
(T2D)
and
lower-extremity
peripheral
artery
disease
(PAD)
are
growing
global
health
problems
associated
with
considerable
cardiovascular
(CV)
limb-related
morbidity
mortality,
poor
quality
of
life
high
healthcare
resource
use
costs.
Diabetes
is
a
well-known
risk
factor
for
PAD,
the
occurrence
PAD
in
people
T2D
further
increases
long-term
complications.
As
available
evidence
primarily
focused
on
overall
population,
we
undertook
systematic
review
to
describe
burden
comorbid
T2D.
The
MEDLINE,
Embase
Cochrane
Library
databases
were
searched
studies
including
published
from
2012
November
2021,
no
restriction
definition,
study
design
or
country.
Hand
searching
conference
proceedings,
reference
lists
included
publications
relevant
identified
reviews
reports
complemented
searches.
We
86
eligible
studies,
mostly
observational
conducted
Asia
Europe,
presenting
data
epidemiology
(n
=
62)
clinical
29),
humanistic
12)
economic
most
common
definition
relied
ankle-brachial
index
values
≤
0.9
(alone
other
parameters).
Incidence
prevalence
varied
substantially
across
studies;
nonetheless,
four
large
multinational
randomised
controlled
trials
found
that
12.5%-22%
had
PAD.
presence
was
major
cause
lower-limb
CV
complications
all-cause
mortality.
Overall,
life,
substantial
To
our
knowledge,
this
provides
comprehensive
overview
date.
In
there
an
urgent
unmet
need
disease-modifying
agents
improve
outcomes.
Diagnostics,
Год журнала:
2024,
Номер
14(10), С. 1053 - 1053
Опубликована: Май 19, 2024
Vascular
calcifications
in
aorto-iliac
arteries
are
emerging
as
crucial
risk
factors
for
cardiovascular
diseases
(CVDs)
with
profound
clinical
implications.
This
systematic
review,
following
PRISMA
guidelines,
investigated
methodologies
measuring
these
and
explored
their
correlation
CVDs
outcomes.
Out
of
698
publications,
11
studies
met
the
inclusion
criteria.
In
total,
7
utilized
manual
methods,
while
4
automated
technologies,
including
artificial
intelligence
deep
learning
image
analyses.
Age,
systolic
blood
pressure,
serum
calcium,
lipoprotein(a)
levels
were
found
to
be
independent
aortic
calcification.
Mortality
from
was
correlated
abdominal
aorta
Patients
requiring
reintervention
after
endovascular
recanalization
exhibited
a
significantly
higher
volume
calcification
iliac
arteries.
Conclusions:
review
reveals
diverse
landscape
measurement
methods
calcifications;
however,
they
lack
standardized
reproducibility
assessment.
Automatic
employing
appear
offer
broader
applicability
less
time-consuming.
Assessment
calcium
scoring
could
routinely
employed
during
preoperative
workups
stratification
detailed
surgical
planning.
Additionally,
its
outcomes
useful
predicting
reinterventions
amputations.
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Июнь 26, 2024
Abstract
Lower
extremity
peripheral
artery
disease
(PAD)
often
results
from
atherosclerosis,
and
is
highly
prevalent
in
patients
with
type
2
diabetes
mellitus
(T2DM).
Individuals
T2DM
exhibit
a
more
severe
manifestation
distal
distribution
of
PAD
compared
to
those
without
diabetes,
adding
complexity
the
therapeutic
management
this
particular
patient
population.
Indeed,
requires
multidisciplinary
individualized
approach
that
addresses
both
systemic
effects
specific
vascular
complications
PAD.
Hence,
cardiovascular
prevention
utmost
importance
PAD,
encompasses
smoking
cessation,
healthy
diet,
structured
exercise,
careful
foot
monitoring,
adherence
routine
preventive
treatments
such
as
statins,
antiplatelet
agents,
angiotensin-converting
enzyme
inhibitors
or
angiotensin
receptor
blockers.
It
also
recommended
incorporate
glucagon-like
peptide-1
agonists
(GLP-1RA)
sodium-glucose
cotransporter-2
(SGLT2i)
medical
due
their
demonstrated
benefits.
However,
impact
these
novel
glucose-lowering
agents
for
individuals
remains
obscured
within
background
outcome
trials
(CVOTs).
In
review
article,
we
distil
evidence,
through
comprehensive
literature
search
CVOTs
clinical
guidelines,
offer
key
directions
optimal
lower
era
GLP-1RA
SGLT2i.
Medicina,
Год журнала:
2024,
Номер
60(7), С. 1179 - 1179
Опубликована: Июль 20, 2024
Peripheral
arterial
disease
(PAD)
prevalence
and
diabetes
mellitus
(DM)
are
continuously
increasing
worldwide.
The
strong
relationship
between
DM
PAD
is
highlighted
by
recent
evidence.
diagnosis
in
diabetic
patients
very
important,
particularly
with
foot
(DFD);
however,
it
often
made
difficult
the
characteristics
of
such
diseases.
Diagnosing
makes
possible
to
identify
at
a
high
cardiovascular
risk
who
require
intensive
treatment
terms
factor
modification
medical
therapy.
purpose
this
review
discuss
diagnostic
methods
that
allow
for
patients.
Non-invasive
tests
address
will
be
discussed,
as
ankle-brachial
index
(ABI),
toe
pressure
(TP),
transcutaneous
oxygen
(TcPO2).
Furthermore,
imaging
methods,
duplex
ultrasound
(DUS),
computed
tomography
angiography
(CTA),
magnetic
resonance
(MRA),
digital
subtraction
(DSA),
described
because
they
diagnosing
anatomical
localization
severity
artery
stenosis
or
occlusion
PAD.
also
discussed
their
ability
assess
perfusion.
Foot
perfusion
assessment
crucial
critical
limb
ischemia
(CLI),
most
advanced
stage,
DFD
impacts
CLI
identification
clinically
relevant
prevent
amputation
mortality.
Peripheral
artery
disease
(PAD)
is
a
major
public
health
concern
worldwide,
associated
with
high
risk
of
mortality
and
morbidity
related
to
cardiovascular
adverse
limb
events.
Despite
significant
advances
in
both
medical
interventional
therapies,
PAD
often
remains
under-diagnosed,
the
prognosis
patients
can
be
difficult
predict.
Artificial
intelligence
(AI)
has
brought
wide
range
opportunities
improve
management
diseases,
from
advanced
imaging
analysis
machine-learning
(ML)-based
predictive
models,
data
using
natural
language
processing
(NLP).
The
aim
this
review
summarize
discuss
current
techniques
based
on
AI
that
have
been
proposed
for
diagnosis
evaluation
PAD.
focused
clinical
studies
AI-methods
detection
classification
as
well
used
AI-models
predict
outcomes
patients.
Through
study
design,
we
model
choices
including
variability
dataset
inputs,
complexity,
interpretability,
challenges
linked
performance
metrics
used.
In
light
results,
potential
interest
decision
support
highlight
future
directions
research
practice.
We
investigated
the
safety
and
efficacy
of
debulking
infrainguinal
lesions
in
patients
with
peripheral
artery
disease
(PAD)
undergoing
endovascular
revascularization
(EVR)
as
part
RECording
Courses
vascular
Diseases
(RECCORD)
registry.
Patient
lesion
specific
characteristics,
including
complexity
score
(LCS)
were
analyzed.
The
primary
endpoint
encompassed:
(i)
clinical
improvement
Rutherford
categories,
(ii)
index
limb
re-interventions,
(iii)
major
amputations
during
follow-up.
secondary
included
need
for
bail-out
stenting.
Overall,
2910
analyzed;
2552
without
358
debulking-assisted
EVR.
Patients
72
(interquartile
range
(IQR)
=
15)
years
old
1027
(35.3%)
had
diabetes.
Overall
complication
rates
similarly
low
vs
non-debulking
group
(4.7
3.2%,
