Toxics,
Год журнала:
2023,
Номер
11(11), С. 903 - 903
Опубликована: Ноя. 5, 2023
Environmental
pollution
is
a
growing
threat
to
natural
ecosystems
and
one
of
the
world’s
most
pressing
concerns.
The
increasing
worldwide
use
pharmaceuticals
has
elevated
their
status
as
significant
emerging
contaminants.
Pharmaceuticals
enter
aquatic
environments
through
multiple
pathways
related
anthropogenic
activity.
Their
high
consumption,
insufficient
waste
treatment,
incapacity
organisms
completely
metabolize
them
contribute
accumulation
in
environments,
posing
all
life
forms.
Various
analytical
methods
have
been
used
quantify
pharmaceuticals.
Biotechnology
advancements
based
on
next-generation
sequencing
(NGS)
techniques,
like
eDNA
metabarcoding,
enabled
development
new
for
assessing
monitoring
ecotoxicological
effects
metabarcoding
valuable
biomonitoring
tool
pharmaceutical
because
it
(a)
provides
an
efficient
method
assess
predict
status,
(b)
identifies
sources,
(c)
tracks
changes
levels
over
time,
(d)
assesses
ecological
impact
pollution,
(e)
helps
prioritize
cleanup
mitigation
efforts,
(f)
offers
insights
into
diversity
composition
microbial
other
bioindicator
communities.
This
review
highlights
issue
while
emphasizing
importance
using
modern
NGS-based
actions
its
environmental
more
consistently
effectively.
Toxics,
Год журнала:
2022,
Номер
10(5), С. 272 - 272
Опубликована: Май 23, 2022
Pharmaceuticals
are
widely
acknowledged
to
be
a
threat
aquatic
life.
Over
the
last
two
decades,
steady
use
of
biologically
active
chemicals
for
human
health
has
been
mirrored
by
rise
in
leaking
these
into
natural
environments.
The
aim
this
work
was
detect
toxicity
sodium
fluoride
(NaF)
exposure
and
platinum-derived
drugs
an
ecological
setting
on
organism
development.
From
24
96
h
post-fertilization,
zebrafish
embryos
were
treated
dosages
NaF
10
mg/L-1
+
cisplatin
(CDDP)
100
μM,
one
with
carboplatin
(CARP)
25
CDDP
μM
CARP
μM.
Fluoride
combination
Cisplatin
Carboplatin
(non-toxic
concentration)
had
effect
survival
hatching
rate
according
study.
Additionally,
it
significantly
disturbed
antioxidant
defense
system
increased
ROS
larvae.
associated
production
apoptosis-related
proteins
(caspase
3,
bax,
bcl-2)
downregulation
acetylcholinesterase
(AChE)
activity,
while
no
seen
single
exposure.
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3123 - 3123
Опубликована: Сен. 10, 2024
Cancer
remains
one
of
the
most
difficult
diseases
to
treat,
requiring
continuous
research
into
innovative
therapeutic
strategies.
Conventional
treatments
such
as
chemotherapy
and
radiotherapy
are
effective
a
certain
extent
but
often
have
significant
side
effects
carry
risk
resistance.
In
recent
years,
concept
dual-acting
therapeutics
has
attracted
considerable
attention,
particularly
combination
DNA
alkylating
agents
antimicrobial
peptides.
alkylation,
well-known
mechanism
in
cancer
therapy,
involves
attachment
alkyl
groups
DNA,
leading
damage
subsequent
cell
death.
Antimicrobial
peptides,
on
other
hand,
been
shown
be
anticancer
due
their
ability
selectively
disrupt
membranes
modulate
immune
responses.
This
review
aims
explore
synergistic
potential
these
two
modalities.
It
examines
mechanisms
action,
current
findings,
promise
they
offer
improve
efficacy
specificity
treatments.
By
combining
cytotoxic
power
alkylation
with
unique
properties
dual-action
may
new
more
approach
fighting
cancer.
Catalysis Today,
Год журнала:
2023,
Номер
423, С. 114010 - 114010
Опубликована: Янв. 23, 2023
Bimetallic
(Fe-Cu)
and
reduced
graphene
oxide
(rGO)/FeCu
catalysts
at
0.2%
wt.
were
developed
by
a
co-precipitation
method,
modifying
the
Fe-Cu
molar
proportions
(i.e.,
Fe40Cu60,
Fe20Cu80
Fe10Cu90)
tested
for
degradation
of
cytostatic
drug,
cyclophosphamide
(CP)
in
aqueous
solution
using
photo-Fenton
process
(UV-Vis).
Physicochemical
characterization
was
carried
out
complementary
techniques
(gas
adsorption,
SEM,
TEM,
XRD,
XPS)
results
correlated
with
catalytic
performance.
The
effect
pH
on
contaminant
catalyst
stability
(metal
leaching)
studied.
point
synergetic
rGO/FeCu
comparison
to
monometallic
or
without
carbonaceous
material.
best
performance
achieved
rGO/Fe10Cu90
achieving
82%
CP
natural
regarding
87%
obtained
under
acid
conditions
(pH
3).
This
fact
avoids
usual
acidification
solutions
during
Fenton-like
processes
prevent
metal
leaching,
increasing
catalysts,
as
demonstrated
after
consecutive
cycles,
maintaining
efficiency
above
75%.
Cytotoxicity
tests
certificated
low
toxicity
by-product
derived
from
process.
