Self-assembled C-Ag hybrid nanoparticle on nanoporous GaN enabled ultra-high enhancement factor SERS sensor for sensitive thiram detection

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133868 - 133868

Опубликована: Фев. 24, 2024

Язык: Английский

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Slide‐Ring Structured Stress‐Electric Coupling Hydrogel Microspheres for Low‐Loss Transduction Between Tissues

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

High transductive loss at tissue injury sites impedes repair. The high dissipation characteristics in the electromechanical conversion of piezoelectric biomaterials pose a challenge. Therefore, supramolecular engineering and microfluidic technology is utilized to introduce slide-ring polyrotaxane conductive polypyrrole construct stress-electric coupling hydrogel microspheres. molecular slippage mechanism structure stores releases mechanical energy, reducing loss, barium titanate enables stress-electricity conversion, conjugated π-electron movement network improves internal electron transfer efficiency microspheres, thereby for first time. Compared traditional low-dissipation microspheres increased by 2.3 times, energy decreased 43%. At cellular level, electrical signals generated triggered Ca

Язык: Английский

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The autophagy-mediated mechanism via TSC1/mTOR signaling pathway in thiram-induced tibial dyschondroplasia of broilers

The Science of The Total Environment, Год журнала: 2024, Номер 928, С. 172305 - 172305

Опубликована: Апрель 7, 2024

Язык: Английский

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Preparation of cellulose-based flexible SERS and its application for rapid and ultra-sensitive detection of thiram on fruits and vegetables

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 129941 - 129941

Опубликована: Фев. 9, 2024

Язык: Английский

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miR-181b-1-3p affects the proliferation and differentiation of chondrocytes in TD broilers through the WIF1/Wnt/β-catenin pathway

Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 197, С. 105649 - 105649

Опубликована: Окт. 15, 2023

Язык: Английский

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miR-206a-3p suppresses the proliferation and differentiation of chicken chondrocytes in tibial dyschondroplasia by targeting BMP6

Poultry Science, Год журнала: 2024, Номер 103(4), С. 103534 - 103534

Опубликована: Фев. 7, 2024

The poultry skeletal system serves multiple functions, not only providing structural integrity but also maintaining the balance of essential minerals such as calcium and phosphorus. However, in recent years, consideration traits has been overlooked selective breeding broilers, resulting an inadequate adaptation to cope with rapid increase body weight. Consequently, this leads lameness bone diseases tibial dyschondroplasia (TD), which significantly impact production performance broilers. Accumulating evidence shown that microRNAs (miRNA) play a crucial role differentiation, formation, disease cartilage. miRNA-mediated molecular mechanism underlying chicken TD formation is still poorly understood. objective study was investigate biological function regulatory miRNA formation. Based on transcriptome sequencing cartilage healthy group group, miR-206a-3p found be highly expressed explored through transfection test mimics inhibitor. In study, we utilized qRT-PCR, CCK-8, EdU, western blot, flow cytometry detect proliferation, apoptosis chondrocytes. results revealed suppressed proliferation differentiation chondrocytes while promoting their programmed cell death. Furthermore, biosynthesis dual luciferase assays, it determined BMP6 direct target gene miR-206a-3p. This finding further supported by rescue experiments confirmed involvement pathway governed Our suggest can inhibits promote BMP-6 suppressing Smad2/3 signaling

Язык: Английский

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Thiram-induced ER stress promotes mitochondrial calcium signaling and NLRP3 inflammasome activation in a tissue specific manner

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 293, С. 118026 - 118026

Опубликована: Март 1, 2025

Thiram, a broadly used dithiocarbamate fungicide, exaggerates endoplasmic reticulum (ER) stress and interferes with mitochondrial function, thus disrupting cellular homeostasis. Here, we intend to identify the molecular actions of thiram at mitochondrial-associated ER membranes (MAMs) that lead induction calcium overload in both liver bone tissues. Taken together, show thiram-induced remodelling MAMs leads huge dysregulation. Histological immunohistochemical examinations revealed hyperactivation IP3R1 mediated release calcium, but uptake was by voltage-dependent anion channels VDAC1. This response characterized increased glucose regulated protein 78 (GRP78) expression tibial growth plates (GP). In this respect, new liver-bone axis delineated for stress. More interestingly, activation NLRP3 inflammasome very striking not Hence, results highlight systemic effects identifying critical metabolic junction might play role disorders such as dyschondroplasia related disorders, e.g., osteoarthritis osteoporosis.

Язык: Английский

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Bacillus amyloliquefaciens attenuates the intestinal permeability, oxidative stress and endoplasmic reticulum stress: transcriptome and microbiome analyses in weaned piglets

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Май 13, 2024

Endoplasmic reticulum (ER) stress is related to oxidative (OS) and leads intestinal injury. Bacillus amyloliquefaciens SC06 (SC06) can regulate OS, but its roles in ER remains unclear. Using a 2 × factorial design, 32 weaned piglets were treated by two levels (0 or 1 10 8 CFU/g), either with without diquat (DQ) injection. We found that increased growth performance, decreased ileal permeability, OS DQ-treated piglets. Transcriptome showed differentially expressed genes (DEGs) induced DQ enriched NF-κB signaling pathway. DEGs between DQ- + glutathione metabolism Ileal microbiome revealed the treatment Clostridium Actinobacillus . Correlations microbiota genes. In conclusion, dietary supplementation regulating microbiota.

Язык: Английский

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Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis

Archives of Toxicology, Год журнала: 2024, Номер 98(9), С. 2763 - 2796

Опубликована: Май 17, 2024

Язык: Английский

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Thiram-driven XBP1 and CHOP pathways orchestrate ER stress and avian tibial dyschondroplasia via metabolic inflammatory axis

Pesticide Biochemistry and Physiology, Год журнала: 2025, Номер unknown, С. 106463 - 106463

Опубликована: Май 1, 2025

Язык: Английский

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