Per- and polyfluoroalkyl substances exposure and its influence on the intestinal barrier: An overview on the advances

The Science of The Total Environment, Год журнала: 2022, Номер 852, С. 158362 - 158362

Опубликована: Авг. 30, 2022

Язык: Английский

---

Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study

Environment International, Год журнала: 2024, Номер 187, С. 108687 - 108687

Опубликована: Апрель 23, 2024

The biotoxicity of perfluoroalkyl and polyfluoroalkyl substances (PFASs) to aquatic organisms has been widely concerned. However, studies on toxic effects PFASs are usually evaluated directly by using laboratory exposure rather than validation based data obtained in the field. In this study, wild catfish (Silurus meridinalis) was explored relationship between bioaccumulation lipid disorders. Nine thirteen metabolites were significantly associated with perfluorooctane sulfonate (PFOS) 6:2/8:2Cl-PFESA (trade name F-53B) exposures, respectively; correlated fatty acid (FA) conjugates, FA esters, steroids, glycerophosphate subclasses. metabolism fish its mechanism further analyzed through experiments. Zebrafish (Danio rerio) different sexes underwent PFOS F-53B exposures for 21 days at 100 ng/L μg/L. By determining gene expression levels, hepatic contents, histopathological change, adverse order male or female μg/L/F-53(−|-)B > μg/L ng/L/F-53(−|-)B PFOS; stress response more intensive that female. activated peroxisome proliferator-activated receptor pathway, promoting processes total cholesterol (T-CHO) transport, β-oxidation, synthesis, finally induced T-CHO transportation from blood into liver, then accelerated ester transformation, CHO steroids. Laboratory experiments confirmed field analysis. This study innovatively their mechanisms highlighting concerns regarding health risks.

Язык: Английский

---

Bone cell differentiation and mineralization in wild-type and osteogenesis imperfecta zebrafish are compromised by per- and poly-fluoroalkyl substances (PFAS)

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 17, 2025

Perfluorinated compounds (PFAS) are well recognized toxic pollutants for humans, but if their effect is equally harmful healthy and fragile people unknown. Addressing this question represents a need ensuring global health wellbeing to all individuals in world facing the progressive increase of aging related diseases. This study aimed evaluate impact perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) perfluorohexanoic (PFHxA) exposure on development skeletal phenotype using osteogenesis imperfecta (OI) zebrafish model Chihuahua (Chi/+), carrying dominant glycine substitution α1 chain collagen I wild-type (WT) littermates. To purpose Chi/+ WT expressing green fluorescent protein under early osteoblast marker osterix were exposed from 1 6 days post fertilization 0.36, 1.5 3.0 mg/L PFOS, 0.005 0.5 PFOA 0.01, 0.48 16.0 PFHxA, investigated. Morphometric measurements, confocal microscopy evaluation operculum area delimited by preosteoblasts mineral deposition analysis following alizarin red staining employed. PFOS highest concentration PFHxA significantly impaired standard length both genotypes. Osteoblast differentiation was compromised only Chi/+. Limited reduced mineralization also observed. No detected after exposure. Apoptosis activated PFOA, specifically mutant osteoblasts. Interestingly, an altered lipid distribution fish revealed pollutants. In conclusion, our data demonstrate that PFAS impair mainly compromising cell whereas alter hepatic genotypes with more severe preosteoblast survival. These results represent first warning sign negative presence genetically determined fragility.

Язык: Английский

---

Bioaccumulation and biomagnification of emerging poly- and perfluoroalkyl substances in marine organisms

The Science of The Total Environment, Год журнала: 2022, Номер 851, С. 158117 - 158117

Опубликована: Авг. 17, 2022

Язык: Английский

---

Metabolomic, Lipidomic, Transcriptomic, and Metagenomic Analyses in Mice Exposed to PFOS and Fed Soluble and Insoluble Dietary Fibers

Environmental Health Perspectives, Год журнала: 2022, Номер 130(11)

Опубликована: Ноя. 1, 2022

Background: Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant that has become significant concern around the world. Exposure to PFOS may alter gut microbiota and liver metabolic homeostasis in mammals, thereby increasing risk of cardiometabolic diseases. Diets high soluble fibers can ameliorate disease risks. Objectives: We aimed test hypothesis (inulin or pectin) could modulate adverse effects by affecting microbe-liver metabolism interactions. Methods: Male C57BL/6J mice were fed an isocaloric diet containing different fibers: a) inulin (soluble), b) pectin c) cellulose (control, insoluble). The exposed drinking water (3μg/g per day) for 7 wk. Multi-omics was used analyze mouse cecum contents. Results: In PFOS-exposed mice, number differentially expressed genes associated with atherogenesis hepatic hyperlipidemia lower those fiber than insoluble fiber. Shotgun metagenomics showed protected against differences microbiome community vs. control mice. It found plasma levels inulin-fed there trend accumulation fiber-fed compared group. Soluble intake ameliorated on host gene expression cecal content structure. Discussions: Results from metabolomic, lipidomic, transcriptomic studies suggest inulin- pectin-fed less susceptible PFOS-induced disturbance, lipid accumulation, transcriptional changes diet-fed Our study advances understanding interaction between microbes under influences pollutants nutrients. results provide new insights into network protection pollutant-induced diseases high-fiber diets. https://doi.org/10.1289/EHP11360

Язык: Английский

---

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonates Exert Stronger Thyroid Homeostasis Disruptive Effects in Newborns than Perfluorooctanesulfonate: Evidence Based on Bayesian Benchmark Dose Values from a Population Study

Environmental Science & Technology, Год журнала: 2023, Номер 57(31), С. 11489 - 11498

Опубликована: Июль 25, 2023

Growing toxicologic evidence suggests that emerging perfluoroalkyl substances (PFASs), like chlorinated polyfluoroalkyl ether sulfonate (Cl-PFESA), may be as toxic or more than perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA). However, further investigations are needed in terms of the human health risk assessment. This study examined effects legacy PFAS exposure on newborn thyroid homeostasis compared disruption caused by 6:2 Cl-PFESA PFOS using a benchmark dose approach. The mixture individual were estimated partial least-squares (PLS) model linear regression, respectively. A Bayesian (BMD) analysis determined BMD value for adverse effect comparison between PFOS. median (interquartile range) concentrations (0.573 [0.351–0.872] ng/mL), (0.674 [0.462–1.007] PFOA (1.457 [1.034, 2.405] ng/mL) found to similar. PLS ranked variables' importance projection (VIP) scores follows: > PFOA. Linear regression showed had positive association with free triiodothyronine (FT3, P = 0.006) (T3, 0.014), while marginally significant FT3 alone (P 0.042). indicated BMD10 (1.01 was lower (1.66 relation 10% increase FT3. These findings suggest Cl-PFESA, an alternative PFOS, has pronounced impact newborns' other PFASs.

Язык: Английский

---

Maternal F-53B exposure during pregnancy and lactation induced glucolipid metabolism disorders and adverse pregnancy outcomes by disturbing gut microbiota in mice

The Science of The Total Environment, Год журнала: 2024, Номер 915, С. 170130 - 170130

Опубликована: Янв. 19, 2024

Язык: Английский

---

F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 277, С. 116399 - 116399

Опубликована: Апрель 26, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as pollutants, can cause palpable environmental health impacts around the world, endocrine disruptors, disrupt homeostasis increase risk of diseases. Chlorinated ether sulfonate (F-53B), a substitute for PFAS, was determined to have potential toxicity. Puberty is stage when sexual organs develop hormones change dramatically, abnormal uterine development lesions lead infertility. This study designed explore impact F-53B on during puberty. Four-week-old female SD rats were exposed 0.125 6.25 mg/L The results showed that interfered with growth sex hormone levels bound oestrogen-related receptors, which affected their function, contributed accumulation reactive oxygen species, promoted cell apoptosis inhibited proliferation, ultimately causing dysplasia.

Язык: Английский

---

Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions

Environmental Pollution, Год журнала: 2023, Номер 339, С. 122756 - 122756

Опубликована: Окт. 14, 2023

Язык: Английский

---

Per- and Polyfluoroalkyl Substances: Impacts on Morphology, Behavior and Lipid Levels in Zebrafish Embryos

Toxics, Год журнала: 2024, Номер 12(3), С. 192 - 192

Опубликована: Фев. 29, 2024

The presence of per- and polyfluoroalkyl substances (PFASs) in aquatic environments is often persistent widespread. Understanding the potential adverse effects from this group chemicals on communities allows for better hazard characterization. This study examines impacts zebrafish (

Язык: Английский

---