Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 183 - 196
Опубликована: Янв. 1, 2025
Язык: Английский
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 183 - 196
Опубликована: Янв. 1, 2025
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 481, С. 148585 - 148585
Опубликована: Янв. 7, 2024
Язык: Английский
Процитировано
57Frontiers in Endocrinology, Год журнала: 2024, Номер 14
Опубликована: Янв. 4, 2024
Plastics found in our everyday environment are becoming an increasing concern for individual and population-level health, the extent of exposure potential toxic effects these contaminants on numerous human organ systems clear. Microplastics (MPs), tiny plastic particles, appear to have many same biological as their precursors compounded effect accumulation different organs. Recently, microplastic was observed placenta, raising important questions related health pregnancies offspring. These concerns particularly heightened considering developmental origins disease (DOHaD) framework, which postulates that utero can programme lifelong The current review examines state knowledge this topic highlights avenues future investigation.
Язык: Английский
Процитировано
44Environmental Research, Год журнала: 2024, Номер 251, С. 118673 - 118673
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
23Environmental Research, Год журнала: 2024, Номер 259, С. 119498 - 119498
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
21Annales de Toxicologie Analytique, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
6Environment International, Год журнала: 2025, Номер 195, С. 109258 - 109258
Опубликована: Янв. 1, 2025
Nanoplastics (NPs) have attracted widespread attention owing to their presence in the body. Recent studies highlighted detrimental effects of NPs on digestive tract. However, no reported an association between exposure and colitis-associated cancer (CAC). An azoxymethane/dextran sodium sulfate-induced CAC model was used, polystyrene nanoparticles (PS-NPs) were selected for long-term exposure. Non-targeted metabolomics 16S rRNA sequencing used detect changes colonic metabolites gut microbes following PS-NPs A lipopolysaccharide (LPS)-treated cell (Caco-2) exposed investigate underlying molecular mechanism. Compared normal control group, mice group exhibited more tumor nodes reactive oxygen species (ROS), higher expression pan-CK Ki-67, severe DNA damage. revealed that altered abundance Allobaculum Lactobacillus, whereas metabolic analysis showed most significant enriched mostly fatty acid metabolism. Experiments LPS intervened Caco-2 cells led lipid peroxidation, oxidative stress, damage Caco-2. Exposure activated phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) signaling pathway both AOM/DSS mouse cellular model. Key proteins involved metabolism downregulated PS-NPs. The significantly inhibited by activation fenofibrate. disturbed induced via PI3K/AKT/mTOR promote progression. Inhibition is a therapeutic controlling PS-NP-induced CAC. Our study provides important reference prevention treatment from perspective environment enhances awareness necessity plastic control.
Язык: Английский
Процитировано
3The Science of The Total Environment, Год журнала: 2023, Номер 904, С. 166745 - 166745
Опубликована: Сен. 4, 2023
Язык: Английский
Процитировано
41RSC Advances, Год журнала: 2023, Номер 13(23), С. 15566 - 15574
Опубликована: Янв. 1, 2023
Microplastics (MPs) are receiving increasing attention from researchers.
Язык: Английский
Процитировано
35The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 169469 - 169469
Опубликована: Дек. 27, 2023
Язык: Английский
Процитировано
33The Science of The Total Environment, Год журнала: 2023, Номер 878, С. 163048 - 163048
Опубликована: Март 28, 2023
Язык: Английский
Процитировано
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