Reproductive Toxicology, Год журнала: 2022, Номер 112, С. 88 - 99
Опубликована: Июль 8, 2022
Язык: Английский
Environmental Science & Technology, Год журнала: 2023, Номер 57(44), С. 16811 - 16822
Опубликована: Окт. 25, 2023
The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant in the environment, which may evoke imperceptible effects humans or wild animals. Hence this study, zebrafish embryos were exposed to DBDPE (0, 0.1, 1, and 10 nM) until sexual maturity (F0), F1 F2 generations cultured without further exposure study multi- transgenerational toxicity underlying mechanism. growth showed sex-different changing profiles across three generations, social behavior confirmed neurotoxicity adult upon life cycle DBDPE. Furthermore, maternal transfer of was not detected, whereas parental neurotransmitters zygotes specifically disturbed offspring. A lack changes generation opposite trends F0 observed series indicators for DNA damage, methylation, gene transcription. Taken together, at environmentally relevant concentrations could induce zebrafish. Our findings also highlighted potential impacts on gregarious fish, would face higher risks from predators.
Язык: Английский
Процитировано
19
The Science of The Total Environment, Год журнала: 2024, Номер 923, С. 170949 - 170949
Опубликована: Фев. 15, 2024
The herbicide linuron can cause endocrine disrupting effects in Xenopus tropicalis frogs, including offspring that were never exposed to the contaminant. mechanisms by which these are transmitted across generations need be further investigated. Here, we examined transgenerational alterations of brain and testis DNA methylation profiles paternally inherited from grandfathers developmentally an environmentally relevant concentration linuron. Reduced representation bisulfite sequencing (RRBS) revealed numerous differentially methylated regions (DMRs) (3060 DMRs) (2551 adult male F2 generation. Key genes involved somatotropic (igfbp4) thyrotropic signaling (dio1 tg) correlated with phenotypical body size, weight, hind limb length plasma glucose levels, indicating changes could potential mediators Testis DMRs found essential for spermatogenesis, meiosis germ cell development (piwil1, spo11 tdrd9) their levels number cells nests per seminiferous tubule, endpoint disrupted spermatogenesis. also identified several central machinery regulates epigenetic landscape (dnmt3a mbd2) histone acetylation (hdac8, ep300, elp3, kat5 kat14), may at least partly drive linuron-induced effects. results this genome-wide profiling contribute better understanding inheritance amphibians.
Язык: Английский
Процитировано
8
Expert Review of Endocrinology & Metabolism, Год журнала: 2024, Номер 19(4), С. 307 - 315
Опубликована: Май 18, 2024
The environmental spread of pollutants has led to a persistent exposure living beings multiple chemicals, by now become ubiquitous in the surrounding environment. Environmental these substances been reported cause multi- and/or transgenerational health effects. Per- and Polyfluorinated Substances (PFAS) raise great concern, given their known effects both as endocrine disruptors potential carcinogens. multi/trans-generational different have investigated several studies, harmful observed also for PFAS.
Язык: Английский
Процитировано
8
Environmental Research, Год журнала: 2021, Номер 205, С. 112435 - 112435
Опубликована: Ноя. 27, 2021
Pregnancy is a complex process requiring tremendous physiological changes in the mother order to fulfill needs of growing fetus, and give birth, expel placenta nurse newborn. These modifications are accompanied with psychological changes, as well variations habits behaviors. As result, this period life considered sensitive window impaired functional can have short- long-term impacts on her health. In addition, dysregulation mechanisms governing placentation been linked chronic diseases later-on for concept known Developmental Origin Health Diseases (DOHaD). This stipulates that any change environment during pre-conception perinatal (in utero neonatal) puberty, be "imprinted" organism, thereby impacting health risk later life. succession events regulated, large part, by hormones growth factors. Therefore, small hormonal balance important effects both developing fetus. An increasing number studies demonstrate exposure endocrine disrupting compounds (EDCs) affect fetus giving rise concerns surrounding these exposures. review will an overview happen pregnancy respect mother, placenta, current literature regarding EDCs specific exposure.
Язык: Английский
Процитировано
33
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 283, С. 116848 - 116848
Опубликована: Авг. 7, 2024
This comprehensive review articulates critical insights into the nexus of environmental stressors and their health impacts across diverse species, underscoring significant findings that reveal profound effects on both wildlife human systems. Central to our examination is role pollutants, climate variables, pathogens in contributing complex disease dynamics physiological disruptions, with particular emphasis immune endocrine functions. research brings light emerging evidence severe implications pressures a variety taxa, including predatory mammals, raptorial birds, seabirds, fish, humans, which are pivotal as indicators broader ecosystem stability. We delve nuanced interplay between degradation zoonotic diseases, highlighting novel intersections pose risks biodiversity populations. The critically evaluates current methodologies advances understanding morphological, histopathological, biochemical responses these organisms stressors. discuss for conservation strategies, advocating more integrated approach incorporates zoonoses pollution control. synthesis not only contributes academic discourse but also aims influence policy by aligning Global Goals Sustainable Development. It underscores urgent need sustainable interactions humans environments, preserving ensuring global security. By presenting detailed analysis interdependencies biological health, this highlights gaps provides foundation future studies aimed at mitigating pressing issues. Our study it proposes integrative actionable strategies address challenges intersection change public marking crucial step forward planetary science.
Язык: Английский
Процитировано
6
Chemosphere, Год журнала: 2024, Номер 363, С. 142894 - 142894
Опубликована: Июль 17, 2024
Язык: Английский
Процитировано
5
Scientific Reports, Год журнала: 2022, Номер 12(1)
Опубликована: Апрель 2, 2022
Goldfish enter a hypometabolic state to survive chronic hypoxia. We recently described tissue-specific contributions of membrane lipid composition remodeling and mitochondrial function metabolic suppression across different goldfish tissues. However, the molecular especially epigenetic foundations hypoxia tolerance in under are not well understood. Here we show that components oxygen-sensing machinery robustly activated tissues irrespective duration. Induction gene expression enzymes involved DNA methylation turnover microRNA biogenesis suggest role for transcriptional post-transcriptional hypoxia-acclimated brain. Conversely, mechanistic target rapamycin-dependent translational activity is reduced liver white muscle, suggesting this pathway does contribute lowering cellular energy expenditure. Finally, evidence supports previously reported hypoxia-dependent changes cholesterol, metabolism via transcripts cholesterol biosynthesis, β-oxidation, fusion multiple Overall, study shows induces tissues, repressive marks brain dynamics promoting suppression.
Язык: Английский
Процитировано
21
Cells, Год журнала: 2022, Номер 11(19), С. 3163 - 3163
Опубликована: Окт. 9, 2022
Environmental toxicants (ETs) are an exogenous chemical group diffused in the environment that contaminate food, water, air and soil, through food chain, they bioaccumulate into organisms. In mammals, exposure to ETs can affect both male female fertility their reproductive health complex alterations impact gametogeneses, among other processes. humans, direct concurs declining of fertility, its transmission across generations has been recently proposed. However, multi- transgenerational inheritances ET reprotoxicity have only demonstrated animals. Here, we review recent studies performed on laboratory model animals investigating effects ETs, such as BPA, phthalates, pesticides persistent contaminants, system transmitted generations. This includes multigenerational effects, where compounds cannot be excluded, unexposed Additionally, report epigenetic mechanisms, DNA methylation, histone tails noncoding RNAs, which may play a mechanistic role nongenetic environmental information germline
Язык: Английский
Процитировано
21
Frontiers in Physiology, Год журнала: 2022, Номер 13
Опубликована: Июль 22, 2022
There is current great international concern about the contribution of environmental pollution to global burden disease particularly in developing, low- and medium-income countries. Industrial activities, urbanization, developmental projects as well various increased anthropogenic activities involving improper generation, management disposal pollutants have rendered today’s environment highly polluted with pollutants. These include toxic metals (lead, cadmium, mercury, arsenic), polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pesticides diesel exhaust particles most which appear be ubiquitous long-term persistence a wide range toxicities such oxidative stress among others. Oxidative stress, may arise from production damaging free radicals emanating pollutant depressed bioavailability antioxidant defenses causes altered biochemical physiological mechanisms has been implicated all known human pathologies are chronic. also affects both flora fauna plants very important components terrestrial significant contributors nutrients for man animals. It remarkable that aquatic sea animals creatures resident polluted, leading affect survival animals, sharing stress. environments an overarching effect on health. Antioxidants neutralize thus, they play protective roles onset, progression severity unmitigated generation ultimately manifest Consequently, health organisms protected by mitigating employing principles nutritional medicine, essentially based antioxidants derived mainly plants, serve panacea vicious state consequently, population. Understanding total picture integrating effects central sustainable population require multi-sectoral collaborations diverse disciplinary perspectives; basically environmental, agricultural sectors.
Язык: Английский
Процитировано
20
Environmental Science & Technology, Год журнала: 2022, Номер 56(12), С. 8496 - 8506
Опубликована: Май 24, 2022
The neurodevelopmental process is highly vulnerable to environmental stress from exposure endocrine-disrupting chemicals. Perfluorinated iodine alkanes (PFIs) possess estrogenic activities, while their potential toxicity remains blurry. In the present study, effects of two PFIs, including dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were investigated in neural differentiation mouse embryonic stem cells (mESCs). Without influencing cytobiological mESCs, PFIs interfered triploblastic development by increasing ectodermal differentiation, thus promoting subsequent neurogenesis. temporal regulation Notch-Hes signaling through targeting mmu-miRNA-34a-5p provided a substantial explanation for underlying mechanism PFI-promoted mESC commitment lineage. findings herein new knowledge on toxicities which would help advance health risk assessment these kinds emerging
Язык: Английский
Процитировано
17