RSC Chemical Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 17, 2024
An artesunate-modified half-sandwich iridium( iii ) complex inhibits colon cancer cell proliferation and metastasis through the STAT3 pathway.
Язык: Английский
Food Bioscience, Год журнала: 2025, Номер unknown, С. 105934 - 105934
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Phytotherapy Research, Год журнала: 2024, Номер 38(7), С. 3525 - 3551
Опубликована: Май 3, 2024
Abstract Colorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy an evolutionarily highly conserved degradation pathway involved in a variety processes, such as maintenance homeostasis clearance foreign bodies, its imbalance associated with many diseases. However, role autophagy CRC progression remains controversial, it has dual function, affecting either or survival, senescence tumor therapy. Indeed, numerous data have been presented that serves alternative apoptosis when latter ineffective apoptosis‐resistant cells, which why also referred programmed type II. Curcumin, active constituents Curcuma longa , great potential combat influencing various signaling pathways epigenetic regulation safe cost‐effective approach. This review discusses efficacy curcumin against vitro vivo, particularly modulation pathways. While clinical studies assessed prevention treatment, none specifically examined Nonetheless, we offer overview correlations support use this polyphenol prophylactic co‐therapeutic agent CRC.
Язык: Английский
Процитировано
11
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2024, Номер 16(8), С. 1500 - 1500
Опубликована: Апрель 14, 2024
Heat shock proteins (Hsps) are involved in one of the adaptive mechanisms protecting cells against environmental and metabolic stress. Moreover, large role these carcinogenesis process, as well chemoresistance, was noticed. This review aims to draw attention possibilities using Hsps developing new cancer therapy methods, indicate directions for future research on this topic. In order discuss matter, a thorough latest scientific literature carried out, taking into account importance selected from Hsp family, including Hsp27, Hsp40, Hsp60, Hsp70, Hsp90 Hsp110. One more characteristic features all is that they play multifaceted progression, which makes them an obvious target modern anticancer therapy. Some researchers emphasize directly inhibiting action proteins. turn, others point their possible use design vaccines, would work by inducing immune response various types cancer. Due possibilities, it believed may contribute progress oncoimmunology, thus help development therapies, be characterized higher effectiveness lower toxicity patients.
Язык: Английский
Процитировано
8
BMC Cancer, Год журнала: 2024, Номер 24(1)
Опубликована: Сен. 12, 2024
Язык: Английский
Процитировано
6
Medical Oncology, Год журнала: 2025, Номер 42(6)
Опубликована: Май 23, 2025
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2023, Номер 12(30)
Опубликована: Сен. 6, 2023
The pathophysiology of osteoarthritis (OA) is closely linked to autophagy abnormalities in articular chondrocytes, the sole mature cell type healthy cartilage. Nevertheless, precise molecular mechanism remains uncertain. Previous research has demonstrated that leptin activates mTORC1 , thereby inhibiting chondrocyte during progression OA. In this study, it presence induces a substantial increase expression STAT3, leading notable decrease REDD1 and subsequent phosphorylation p70S6K, recognized downstream effector mTORC1. Conversely, inhibition yields contrasting effects. Additionally, potential advantages utilizing sustained intra-articular release inhibitor (LI) via an injectable, thermosensitive poly(D,L-lactide)-poly(ethylene glycol)-poly(D,L-lactide) (PDLLA-PEG-PDLLA: PLEL) hydrogel delivery system for purpose investigating its impact on cartilage repair are explored. study conducted LI-loaded PLEL (PLEL@LI) demonstrates remarkable efficacy OA displays encouraging therapeutic restoration subchondral bone These findings establish solid foundation advancement pioneering treatment approach PLEL@LI
Язык: Английский
Процитировано
9
World Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 16(5), С. 1705 - 1724
Опубликована: Май 7, 2024
Colorectal cancer (CRC) remains one of the most commonly diagnosed and deadliest types worldwide. CRC displays a desmoplastic reaction (DR) that has been inversely associated with poor prognosis; less DR is better prognosis. This generates excessive connective tissue, in which cancer-associated fibroblasts (CAFs) are critical cells form part tumor microenvironment. CAFs directly involved tumorigenesis through different mechanisms. However, their role immunosuppression not well understood, precise signal transducers activators transcription (STATs) mediating CAF activity unclear. Among myriad chemical biological factors affect CAFs, cytokines mediate function by activating STAT signaling pathways. Thus, harmful effects favoring growth invasion may be modulated using inhibitors. Here, we analyze impact STATs on immunoregulatory role.
Язык: Английский
Процитировано
3
Digestive Diseases and Sciences, Год журнала: 2024, Номер 69(8), С. 2841 - 2855
Опубликована: Май 30, 2024
Язык: Английский
Процитировано
3
Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 749, С. 151323 - 151323
Опубликована: Янв. 12, 2025
Язык: Английский
Процитировано
0