Integrative Analysis of Metabolite Changes and Potential Health Effects in Pomegranate Juice Fermentation

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105934 - 105934

Published: Jan. 1, 2025

Language: Английский

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Heat Shock Proteins, a Double-Edged Sword: Significance in Cancer Progression, Chemotherapy Resistance and Novel Therapeutic Perspectives

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1500 - 1500

Published: April 14, 2024

Heat shock proteins (Hsps) are involved in one of the adaptive mechanisms protecting cells against environmental and metabolic stress. Moreover, large role these carcinogenesis process, as well chemoresistance, was noticed. This review aims to draw attention possibilities using Hsps developing new cancer therapy methods, indicate directions for future research on this topic. In order discuss matter, a thorough latest scientific literature carried out, taking into account importance selected from Hsp family, including Hsp27, Hsp40, Hsp60, Hsp70, Hsp90 Hsp110. One more characteristic features all is that they play multifaceted progression, which makes them an obvious target modern anticancer therapy. Some researchers emphasize directly inhibiting action proteins. turn, others point their possible use design vaccines, would work by inducing immune response various types cancer. Due possibilities, it believed may contribute progress oncoimmunology, thus help development therapies, be characterized higher effectiveness lower toxicity patients.

Language: Английский

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Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3525 - 3551

Published: May 3, 2024

Abstract Colorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy an evolutionarily highly conserved degradation pathway involved in a variety processes, such as maintenance homeostasis clearance foreign bodies, its imbalance associated with many diseases. However, role autophagy CRC progression remains controversial, it has dual function, affecting either or survival, senescence tumor therapy. Indeed, numerous data have been presented that serves alternative apoptosis when latter ineffective apoptosis‐resistant cells, which why also referred programmed type II. Curcumin, active constituents Curcuma longa , great potential combat influencing various signaling pathways epigenetic regulation safe cost‐effective approach. This review discusses efficacy curcumin against vitro vivo, particularly modulation pathways. While clinical studies assessed prevention treatment, none specifically examined Nonetheless, we offer overview correlations support use this polyphenol prophylactic co‐therapeutic agent CRC.

Language: Английский

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Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 12, 2024

Language: Английский

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A Novel Piperine Derivative HJJ_3_5 Inhibits Colorectal Cancer Progression by Modulating EMT Signaling Pathways

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 749, P. 151323 - 151323

Published: Jan. 12, 2025

Language: Английский

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A Review on the Role of Human Solute Carriers Transporters in Cancer

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 1, 2025

ABSTRACT Background and Aim The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable transporting different acids, cancer may develop as a result these transporters' over‐expression due to their complex formation with other biological molecules. Therefore, this review investigated the role SLC progression cancer. Methods We retrieved data from Google Scholar, Web Science, PubMed, Cochrane Library, EMBASE regarding influence human SLCs on development Articles published English before August 2024 were included study. Results overexpression is strongly related cell proliferation angiogenesis number types including thyroid, pancreatic, lung, hepatocellular, colon cancers. They crucial stimulation several signaling pathways, particularly mTOR kinase activity, which starts cascade, protein synthesis, growth, proliferation, inhibits apoptosis cancerous cells. Furthermore, they contribute activation PI3K/AKT signaling, has impact invasion, death Thus, become potential therapeutic target that plays drug resistance, microenvironment regulation, modulation immune response. Conclusion recognized progression. confirm our findings, case‐control study required investigate acid development.

Language: Английский

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Bone tumors: a systematic review of prevalence, risk determinants, and survival patterns

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Language: Английский

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ANXA2 promotes chondrocyte differentiation and fracture healing by regulating the phosphorylation of STAT3 and PI3K/AKT signaling pathways

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111617 - 111617

Published: Jan. 1, 2025

Language: Английский

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CDCA7 enhances STAT3 transcriptional activity to regulate aerobic glycolysis and promote pancreatic cancer progression and gemcitabine resistance

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 4, 2025

Language: Английский

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Lipid-based nanomedicine for colorectal cancer: Progress and prospects

Alexandria Engineering Journal, Journal Year: 2025, Volume and Issue: 122, P. 385 - 398

Published: March 18, 2025

Language: Английский

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