Advancements in dextran-based nanocarriers for treatment and imaging of breast cancer

International Journal of Pharmaceutics, Год журнала: 2023, Номер 643, С. 123276 - 123276

Опубликована: Июль 27, 2023

Язык: Английский

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Carbon nanotube-mediated platinum-based drug delivery for the treatment of cancer: Advancements and future perspectives

European Polymer Journal, Год журнала: 2024, Номер 206, С. 112800 - 112800

Опубликована: Янв. 26, 2024

Язык: Английский

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Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Polymers, Год журнала: 2024, Номер 16(6), С. 843 - 843

Опубликована: Март 19, 2024

Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, off-target effects of chemotherapy known to produce side and dose-limiting toxicities. Novel delivery platforms based on natural synthetic polymers enhanced pharmacokinetic potential treatment cancer have grown tremendously over past 10 years. Polymers can facilitate selective targeting, enhance prolong circulation, improve delivery, provide controlled release cargos through various mechanisms, including physical adsorption, chemical conjugation, internal loading. Notably, that biodegradable, biocompatible, physicochemically stable considered be ideal carriers. This biomimetic bio-inspired system offers a bright future effective drug overcome obstacles encountered. review focuses barriers impact success as well recent developments improving

Язык: Английский

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Emerging natural polymer-based architectured nanotherapeutics for the treatment of cancer

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 129434 - 129434

Опубликована: Янв. 15, 2024

Язык: Английский

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Recent progress in zein nanoparticles: A promising approach for advancing cancer therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 97, С. 105770 - 105770

Опубликована: Май 11, 2024

Язык: Английский

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An analytical review of the therapeutic application of recent trends in MIL-based delivery systems in cancer therapy

Microchimica Acta, Год журнала: 2025, Номер 192(2)

Опубликована: Янв. 16, 2025

Язык: Английский

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Nanotechnology-empowered strategies in treatment of skin cancer

Environmental Research, Год журнала: 2023, Номер 235, С. 116649 - 116649

Опубликована: Июль 13, 2023

Язык: Английский

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Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment

Drug Discovery Today, Год журнала: 2023, Номер 29(1), С. 103819 - 103819

Опубликована: Ноя. 7, 2023

Язык: Английский

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Hyaluronic Acid – Coated Niosomes for Curcumin Targeted Delivery into Breast Cancer Cells

ChemistrySelect, Год журнала: 2024, Номер 9(3)

Опубликована: Янв. 17, 2024

Abstract This study described a hyaluronic acid (HA) coated niosomes (Nio) encapsulated curcumin (CRM) (CRM‐HA‐Nio) to improve therapeutic properties via targeted delivery. CRM‐HA‐Nio was prepared by thin film hydration method and characterized dynamic light scattering transmission electron microscopy. Release assay performed utilizing dialysis method. Antioxidant, Cell viability, cellular uptake assays were evaluate the biological activity. has 142.93±39.71 nm size with −20.67±1.10 charge showed good stability 93±4.35 % encapsulation efficiency displayed pH‐independent release pattern. 2‐fold antioxidant improvement compared free CRM. much better cytotoxic activity on MCF‐7 cell line IC 50 of 1.851±0.45 μM CRM equal 5.230±0.85 μM, approximately 3‐fold enhancement. may be promising nanocarrier elucidate bioactivity against cancer when oxidative stress is major side effect.

Язык: Английский

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In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes proteins. This review explores the latest advances payload vectorization delivery systems developed for vivo cancer treatments. We discuss viral non-viral organic particles, including lipid based nanoparticles polymeric structures, effective transport plasmids, siRNA, self-amplifying RNA therapeutics. Their physicochemical properties, strategies to overcome intracellular barriers, innovations cell-based carriers engineered extracellular vesicles are highlighted. Moreover, we consider oncolytic viruses, novel capsid modifications, approaches that refine tumor targeting immunomodulation. Ongoing clinical trials regulatory frameworks guide future directions emphasize need safe, scalable production. The potential convergence these with combination therapies paves way toward personalized medicine.

Язык: Английский

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