Clinical & Translational Oncology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 18, 2024
Язык: Английский
Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102068 - 102068
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
International Journal of Oral Science, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 2, 2025
Abstract Oral squamous cell carcinoma (OSCC) is the most common manifestation of oral cancer. It has been proposed that periodontal pathogens contribute to OSCC progression, mainly by their virulence factors. However, main pathogen and its mechanism modulate cells remains not fully understood. In this study we investigate host-pathogen pathways in computational proteomics behind cancer progression microbiome. The were analyzed secretome biopsies from patients with healthy controls mass spectrometry. Then, functional assays performed evaluate highlighted Host proteins associated LPS response, migration/adhesion, metabolism amino acids significantly upregulated human proteome, whereas complement cascade was downregulated malignant samples. microbiome analysis revealed large number variety peptides Fusobacterium nucleatum ( F. ) samples, which several enzymes L-glutamate degradation pathway found, indicating used as an energy source, catabolized into butyrate bacteria. fact, observed modulates cystine/glutamate antiporter line increasing SLC7A11 expression, promoting efflux favoring bacterial infection. Finally, our results showed metabolic derivates promote tumor spheroids growth, spheroids-derived detachment, epithelial-mesenchymal transition Galectin-9 upregulation. Altogether, promotes pro-tumoral
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Апрель 23, 2024
Abstract The present study explored the anticancer activity of a Chitosan-based nanogel incorporating thiocolchicoside and lauric acid (CTL) against oral cancer cell lines (KB-1). Cell viability, AO/EtBr dual staining cycle analysis were done to evaluate impact CTL on cells. Real-time PCR was performed analyze proapoptotic antiapoptotic gene expression in CTL-treated KB-1 Further, molecular docking conducted explore interaction our key ingredient, its binding affinities. demonstrated potent by inhibiting proliferation inducing arrest Gene indicated alterations Bax Bcl-2 genes; treatment increased mRNA inhibited expression, which showed potential mechanisms nanogel's action. It found that can stabilize protein's function or restore it as tumour suppressor. exhibited excellent cytotoxicity effects, making candidate for non-toxic chemotherapy nanomedicine. Furthermore, ability modulate highlights targeted therapy. This research contributes growing interest nanogels their applications treatment.
Язык: Английский
Процитировано
8
Clinical & Translational Oncology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
4
Biomedicines, Год журнала: 2025, Номер 13(1), С. 134 - 134
Опубликована: Янв. 8, 2025
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies head and neck (HNSCC). HNSCC recognized as eighth commonly occurring cancer globally in men. It essential to distinguish between cancers arising regions due significant differences their etiologies, treatment approaches, prognoses. As Cancer Genome Atlas (TCGA) dataset available HNSCC, survival analysis prognosis OSCC patients based on TCGA for discovering gene expression-based prognostic biomarkers limited. To address this paucity, we aimed provide comprehensive evidence by recruiting studies that have reported new biomarkers/signatures establish a model predict patients. Using PubMed search, identified 34 been using least absolute shrinkage selection operator (LASSO)-based Cox regression analyses signature related different pathways from past 4 years. Our review was focused summarizing these signatures implications targeted therapy FDA-approved drugs. Furthermore, conducted an LASSO signatures. findings revealed 13 correlated greater number regulatory T cells (Tregs) protective with increased recurrence-free overall rates. Conversely, two displayed opposing trend cases OSCC. We will also explore how dysregulation impacts immune status, promoting tumor evasion or, conversely, enhancing surveillance. Overall, insight future anti-cancer therapies potential associated poor
Язык: Английский
Процитировано
0
Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Abstract Across diverse cultures, herbal remedies have been used to alleviate oral discomfort and maintain dental hygiene. This review presents studies on with remarkable antimicrobial, anti-inflammatory, antioxidant, anticancer, anticaries, analgesic, healing properties. The manuscripts demonstrate the depth of scientific inquiry into for management various health conditions. These include gingivitis, ulcers, mucositis, periodontitis, pathogens, carcinoma, xerostomia, caries. Researchers investigated phytochemical pharmacological properties plant-derived compounds their extracts evaluated interactions pathogens inflammatory processes. convergence traditional knowledge rigorous investigation offers a compelling narrative, fostering deeper understanding as viable alternatives conventional interventions. work has potential provide patients access gentle, yet effective solutions, simultaneously offer professionals opportunity enrich knowledge, ability personalized, holistic care. highlights symbiotic relationship between medicine understanding, emphasizing importance disseminating this benefit both practitioners patients, enabling evidence-based decision-making in exploration promising alternative, potentially mitigating some these side effects while promoting more natural manner.
Язык: Английский
Процитировано
0
Immuno, Год журнала: 2025, Номер 5(1), С. 8 - 8
Опубликована: Фев. 25, 2025
NK cells have traditionally been classified as effectors of innate immunity, even though they also exhibit some features adaptive immunity such memory. contribute to the lysis and growth inhibition cancer, mediating direct cytotoxicity antibody-dependent cellular (ADCC) regulating functions other immune cells, respectively. regulate function via release inflammatory cytokines chemokines. Currently, cell therapeutics in oral cancer less efficient due several limitations, follows: (a) lower percentages peripheral blood cells; (b) limited survival decreased especially tumor microenvironment; (c) a lack tools or methodologies expand activate levels that are required for effective targeting cancer. To overcome these we established demonstrated novel technology activating expanding highly functional coined supercharged (sNK) cells. This review summarizes characteristics sNK highlights their superior anti-cancer activity when compared primary activated
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(2), С. e24236 - e24236
Опубликована: Янв. 1, 2024
The integrin subunit α3 (ITGA3) is a member of the alpha chain protein family, which could promote progression, metastasis, and invasion in some cancers. Still, its function tumor microenvironment (TME), cancer prognosis, immunotherapy remains unclear. A multifaceted analysis ITGA3 pan-cancer utilizing various databases online web tools revealed was aberrantly expressed tissues upregulated most cancers, may be related to genomic alterations methylation modification. In addition, significantly correlated with poor or better prognosis patients, immune-related pathways hallmark, immune infiltration, checkpoints, revealing biological microenvironment, immunity. We also found that predict response based on cytokine-treated samples cohorts. participate shaping regulating affect response, promising predictive biomarker potential therapeutic target work synergistically boost efficacy. Finally, targeted compound inhibitors sensitive drugs were screened using ConnectivityMap (CMap) CellMiner, AutoDock Tools used for molecular docking.
Язык: Английский
Процитировано
3
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Март 1, 2024
The oral cavity presents a diverse microbiota in dynamic balance with the host. Disruption of microbial community can promote dysregulation local immune response which could generate diseases. Additionally, alterations host system result inflammatory disorders. Different microorganisms have been associated establishment and progression Oral pathogens/diseases modulate components response. Myeloid-derived suppressor cells (MDSCs) own immunoregulatory functions involved different conditions such as infectious processes, autoimmune diseases, cancer. aim this review is to provide comprehensive overview generation, phenotypes, biological MDSCs Also, it addressed aspects presence major pathogens. mainly analyzed periodontal disease Sjögren’s syndrome be outcome these Studies including participation other important diseases are very scarce. Major bacterial fungal pathogens expansion, subpopulations, recruitment, metabolism, immunosuppressive activity osteoclastogenic potential MDSCs. Moreover, MDSC plasticity exhibited diseases/oral appears relevant potentially useful searching possible treatments. Further analyses context allow understand contribution fine-tuned between microorganism biofilm, well their involvement development when altered.
Язык: Английский
Процитировано
3
Pathology - Research and Practice, Год журнала: 2024, Номер 256, С. 155266 - 155266
Опубликована: Март 19, 2024
Язык: Английский
Процитировано
3