Life,
Год журнала:
2025,
Номер
15(1), С. 112 - 112
Опубликована: Янв. 16, 2025
The
potential
health
risks
posed
by
the
coexistence
of
nanoplastics
(NPs)
and
triclosan
(TCS)
have
garnered
significant
attention.
However,
effects
underlying
mechanisms
NPs
TCS
on
key
functional
proteins
at
molecular
level
remain
poorly
understood.
This
study
reports
effect
polystyrene
(PSNPs)
binding
to
human
serum
albumin
(HSA)
using
multispectral
methods
simulation
systems.
experimental
results
show
that
significantly
inhibits
HSA
esterase
activity,
with
exacerbating
inhibition
in
presence
PSNPs,
which
is
attributed
alteration
conformation
microenvironment
amino
acid
residues
induced
PSNPs.
Molecular
docking
site
marker
competitive
studies
indicate
predominantly
binds
I
subdomain
Sudlow
II
PSNPs
does
not
affect
sites.
Spectra
analyses
quenching
mechanism
between
belongs
static
type
change
fluorescence
type.
conformational
alterations
are
further
enhanced
indicating
enhance
making
more
accessible
provides
valuable
information
about
toxicity
case
co-exposure.
Critical Reviews in Environmental Science and Technology,
Год журнала:
2024,
Номер
54(18), С. 1340 - 1363
Опубликована: Фев. 2, 2024
Triclosan
(TCS)
is
an
anti-microbial
widely
used
in
personal
care
and
medical
antibacterial
products.
Despite
the
widespread
occurrence
of
TCS
municipal
sewage
sludge,
understanding
toward
fate
within
treatment
environmental
risks
eventual
land
application
still
limited.
This
review
summarizes
loads
transfer
mechanisms
process,
sludge
management
application,
its
potential
impacts.
from
to
mainly
occurs
primary
sedimentation
representing
2.50
4.58
times
more
compared
secondary
process.
facilitated
through
adsorption
because
presence
humic
acid-like
protein-like
substances
sludge.
Both
anaerobic
digestion
aerobic
composting
contribute
degradation
with
being
effective,
exhibiting
rates
1.04–2.87
higher
than
those
observed
digestion.
After
majorly
dissipates
soil
biodegradation
by
fungi
bacteria,
potentially
posing
risks,
such
as
inhibiting
seedling
growth
plant
species.
Additionally,
TCS,
coupled
formation
subsequent
MeTCS,
observed,
MeTCS
a
half-life
greater
toxicity
parent
compound
(TCS).
Overall,
this
research
offers
vital
insights
enhance
TCS's
migration
processes
soil.
It
also
provides
guidance
protection
sustainable
resource
management.
Antibiotics,
Год журнала:
2022,
Номер
11(6), С. 735 - 735
Опубликована: Май 30, 2022
Triclosan
(TCS),
a
broad-spectrum
antimicrobial
agent,
has
been
widely
used
in
personal
care
products,
medical
plastic
cutting
boards,
and
food
storage
containers.
Colgate
Total®
toothpaste,
containing
10
mM
TCS,
is
effective
controlling
biofilm
formation
maintaining
gingival
health.
Given
its
broad
usage,
TCS
present
ubiquitously
the
environment.
strong
lipophilicity
accumulation
ability
organisms,
it
potentially
harmful
to
biohealth.
Several
reports
suggest
toxicity
of
this
compound,
which
inserted
class
endocrine
disrupting
chemicals
(EDCs).
In
September
2016,
was
banned
by
U.S.
Food
Drug
Administration
(FDA)
European
Union
soap
products.
Despite
these
problems,
application
products
within
certain
limits
still
allowed.
Today,
unclear
whether
truly
toxic
mammals
adverse
effects
continuous,
long-term,
low
concentration
exposure
remain
unknown.
Indeed,
some
recent
use
as
repositioned
drug
for
cancer
treatment
cutaneous
leishmaniasis.
scenario
necessary
investigate
advantages
disadvantages
understand
advisable
or
not.
This
review
intends
highlight
pros
cons
that
are
associated
with
humans.
Sustainability,
Год журнала:
2022,
Номер
14(15), С. 9529 - 9529
Опубликована: Авг. 3, 2022
Hematological
parameters
and
changes
in
stress-induced
functionalities
of
cellular
enzymes
have
been
recognized
as
valuable
tools
for
monitoring
fish
health
determining
the
toxic
effects
pesticides.
The
present
study
was
conducted
to
evaluate
effect
selected
pesticides
viz.,
Ekalux
(EC-25%),
Impala
(EC-55%),
Neemstar
(EC-15%)
on
freshwater
catfish
Mystus
keletius.
Fish
were
exposed
sub-lethal
concentrations
(mg/L)
pesticide
a
period
7,
14,
21,
28
days.
total
erythrocyte
(RBC),
hemoglobin
(Hb),
hematocrit
(Ht)
packed
cell
volume
values
decreased
with
an
increase
exposure
time
pesticides,
whereas
leucocytes
(WBC),
mean
corpuscular
concentration
(MCHC),
(MCV),
(MCH)
increased
significantly.
A
decrease
(PCV)
coupled
deformed
erythrocytes
signs
anemia
also
observed.
RBC
content
1.43
(million/mm3)
day
7
reduced
1.18
days
14
21.
similar
trend
found
RBC,
which
had
initial
value
1.36
reached
1.10
28.
In
contrast,
from
1.59
control
1.02
Data
indicates
that
order
recorded
maximum
followed
by
model.
Likewise,
overall
pattern
pesticidal
activity
(GDH,
MDH,
SDH)
Neemstar.
Results
indicate
Chlorpyrifos
pesticide-Impala
evoked
tissues
compared
other
two
tested.
Statistical
analysis
summative
data
using
way
ANOVA
statistically
significant
(p-value
<
0.001).
differences
hematological
analyzed
are
attributed
physiological
acclimatization
local
conditions,
influences
energy
metabolism
consequently
determines
status
fish.
Overall,
exhibited
highest
enzyme,
suggest
natural
may
be
preferable
rice
field
application
terms
environmental
safety.
Civil Engineering Journal,
Год журнала:
2024,
Номер
10(5), С. 1645 - 1661
Опубликована: Май 1, 2024
Triclosan
(TCS),
a
common
antibacterial
agent
found
in
numerous
personal
care
products,
has
been
detected
wastewater
and
surface
water
is
now
of
significant
environmental
concern
due
to
its
health
impacts.
To
mitigate
this
issue,
various
treatment
methods
have
explored.
This
study
investigated
the
efficacy
Macadamia
nut
shell
activated
carbon
(MAC)
as
an
economical
adsorbent
for
triclosan
removal.
A
pulsed-bed
column
adsorption
technique
was
applied
enhance
capacity
prolong
operational
lifespan
column.
Batch
experiments
were
conducted
explore
parameters
capacity.
Column
carried
out
investigate
breakthrough
curves
associated
parameters.
In
batch
experiments,
MAC
exhibited
high
TCS
119.05
mg/g,
optimal
conditions
determined.
Adsorption
kinetics
followed
pseudo-second-order
model,
equilibrium
data
well-fitted
by
both
Langmuir
Freundlich
isotherm
models.
showed
superior
performance
compared
fixed-bed
under
specific
(flow
rate:
10
mL/min,
initial
concentration:
60
mg/L,
bed
height:
cm)
removal
height
only
6
cm,
successfully
enhancing
53.40
mg/g
extending
5,280
minutes.
Adapting
columns
from
product
industry
led
extension
life
with
increased
minimized
use
adsorbents
practical
environmentally
friendly
method.
Doi:
10.28991/CEJ-2024-010-05-019
Full
Text:
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